Results 111 to 120 of about 3,031,297 (290)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Collective Phase Sensitivity

, 2008
The collective phase response to a macroscopic external perturbation of a population of interacting nonlinear elements exhibiting collective oscillations is formulated for the case of globally-coupled oscillators.
A. T. Winfree, Hiroshi Kori, Hiroya Nakao, Kensuke Arai, S. C. Manrubia, Y. Kuramoto, Yoji Kawamura, Yoshiki Kuramoto   +7 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Interplay of disorder and interaction in Majorana quantum wires

, 2012
We study the interplay between disorder and interaction in one-dimensional topological superconductors which carry localized Majorana zero-energy states.
Alejandro M. Lobos, Roman M. Lutchyn, S. Coleman, S. Das Sarma, T. Giamarchi   +4 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Paths and stochastic order in open systems

, 2011
The principle of maximum irreversible is proved to be a consequence of a stochastic order of the paths inside the phase space; indeed, the system evolves on the greatest path in the stochastic order.
Lucia, Umberto
core  

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

800oC-stable D022 superlattice in a NiCrFe-based medium entropy alloy

Materials Research Letters
The metastable-stable transition and rapid coarsening of metastable D022 phase remains its Achilles hell, restricting the application of D022-strengthened alloys at service temperatures higher than 650°C. Hence, it is crucial to improve thermal stability
Mei Lin, Jianlin Lu, Yiming Chen, Zhongsheng Yang, Xin Liu, Kaiwei Zhang, Zhijun Wang, Junjie Li, Jincheng Wang, Feng He   +9 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Phase-stabilized dual-comb spectroscopy

, 2019
Optische Frequenzkämme zeichnen sich durch ihre phasenkohärenten, äquidistanten Laserlinien im Spektrum aus. Gegenwärtig werden sie unter anderem neben ihrem ursprünglichen Verwendungszweck für Frequenzmessungen verwendet. Molekulare Spektroskopie profitiert von der großen spektralen Bandbreite.
openaire   +2 more sources