Results 41 to 50 of about 568,853 (267)
Pulmonary tuberculosis case detection in South Sudan
Background: The National Tuberculosis (TB) Control Programme in South Sudan was created in 2006, and non-governmental organizations (NGOs) are its main implementers. Pulmonary tuberculosis (PTB) is a major public health threat.
David L. Lukudu
doaj
Reversibility of phase transformation, a basic requirement for functional properties of shape memory alloys, such as superelasticity, is severely affected by plastic deformation.
Chao Song +7 more
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Phase transformations significantly influence the mechanical properties of Fe-based alloys, making their understanding essential for the design of high-performance alloy materials.
Rosemary Chemeli Korir +2 more
doaj +1 more source
Deformation-assisted diffusion for the enhanced kinetics of dynamic phase transformation
Comparison on the kinetics of two different phase transformations, including phase transformation after deformation and phase transformation during deformation (i.e.
Lijia Zhao +4 more
doaj +1 more source
Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
wiley +1 more source

