Results 71 to 80 of about 821,009 (292)

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

A review on the modeling and simulations of solid-state diffusional phase transformations in metals and alloys

Manufacturing Review, 2018
Solid-state diffusional phase transformations are vital approaches for controlling of the material microstructure and thus tailoring the properties of metals and alloys.
Liu Xueyan, Li Hongwei, Zhan Mei
doaj   +1 more source

The Phase Transformations in Hypoeutectoid Steels Mn-Cr-Ni

Archives of Metallurgy and Materials, 2015
The results of a microstructure and hardness investigations of the hypoeutectoid steels Mn-Cr-Ni, imitating by its chemical composition toughening steels, are presented in the paper.
RoŻniata E., Dziurka R.
doaj   +1 more source

Finite strain Landau theory of high pressure phase transformations

, 2010
The properties of materials near structural phase transitions are often successfully described in the framework of Landau theory. While the focus is usually on phase transitions, which are induced by temperature changes approaching a critical temperature
A Tröster, Anderson O L, Angel R J, Angel R J, Bratkovky A M, Brendel R, Carpenter M A, Chesnut G N, Dove M T, Giddy A P, J Koppensteiner, Kovalev O V, Meyer H W, Pintschovius L, Pérez-Mato J M, R Miletich, Roy D, Salje E K H, Sondergeld P, Toledano J C, Toledano P, Tröster A Schranz W, W Schranz   +22 more
core   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Free energy functionals for efficient phase field crystal modeling of structural phase transformations

, 2010
The phase field crystal (PFC) method has emerged as a promising technique for modeling materials with atomistic resolution on mesoscopic time scales. The approach is numerically much more efficient than classical density functional theory (CDFT), but its
J. W. Martin, Jörg Rottler, Michael Greenwood, Nikolas Provatas   +3 more
core   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Local phase space and edge modes for diffeomorphism-invariant theories

, 2017
We discuss an approach to characterizing local degrees of freedom of a subregion in diffeomorphism-invariant theories using the extended phase space of Donnelly and Freidel, [JHEP 2016 (2016) 102].
Speranza, Antony J.
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source