Results 81 to 90 of about 116,811 (268)

Improved conventional TEM sample preparation exploiting the birefringence of materials [PDF]

BIO Web of Conferences
Brozyniak Aleksander, Stadlmann Karin, Kürnsteiner Philipp, Groiss Heiko   +3 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Enhanced nanoscale phase characterisation in modern steels using precession electron diffraction and energy filtering [PDF]

BIO Web of Conferences
Brozyniak Aleksander, Wallner Matthias, Kürnsteiner Philipp, Oberhumer Peter, Steineder Katharina, Groiss Heiko   +5 more
doaj   +1 more source

A dilatometric study of the phase transformations in 300 and 350 maraging steels during continuous heating rates [PDF]

Materials Research, 2013
The influences of the chemical composition and heating rate have been studied in 300 and 350 maraging steels using dilatometry. For these tests, heating was carried out with heating rates of 1, 10 and 28 °C/s.
Leandro Gomes de Carvalho, Margareth Spangler Andrade, Ronald Lesley Plaut, Fabrício Mendes Souza, Angelo Fernando Padilha   +4 more
doaj  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Elucidating the effect of silicon on Fe-Zn phase formation in galvanized steel via advanced TEM [PDF]

BIO Web of Conferences
Minenkov Alexey, Knapp Johannes, Mörtlbauer Thomas, Groiss Heiko   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

In situ TEM thermal study of MBE and CVD GeSn layers: Cross-section and plan-view geometries [PDF]

BIO Web of Conferences
Martínez Karí, Minenkov Alexey, Aberl Johannes, Brehm Moritz, Groiss Heiko   +4 more
doaj   +1 more source

TOPICAL REVIEW: Structural control of Fe-based alloys through diffusional solid/solid phase transformations in a high magnetic field

Science and Technology of Advanced Materials, 2008
A magnetic field has a remarkable influence on solid/solid phase transformations and it can be used to control the structure and function of materials during phase transformations.
Hideyuki Ohtsuka
doaj