Results 151 to 160 of about 87,708 (328)

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Implications of phase transitions in the early universe

, 1984
Imperial Users ...
Bhattacharjee, P., Bhattacharjee, P.
openaire   +1 more source

Anisotropic to Isotropic Phase Transitions in the Early Universe

, 2012
We propose that the early Universe was not Lorentz symmetric and that a gradual transition to the Lorentz symmetric phase occurred. An underlying form of the Dirac equation hints to such a transition for fermions. Fermions were coupled to space-time in a non-trivial manner such that they were massless in the Lorentz violating phase.
openaire   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Non-thermal production of heavy vector dark matter from relativistic bubble walls

Journal of High Energy Physics
Heavy vector boson dark matter at the TeV scale or higher may be produced non-thermally in a first-order phase transition taking place at a lower energy scale.
Wen-Yuan Ai, Malcolm Fairbairn, Ken Mimasu, Tevong You   +3 more
doaj   +1 more source

Understanding bio‐based polymers: A study of origins, properties, biodegradation and their impact on health and the environment

FEBS Open Bio, EarlyView.
This review provides an overview of bio‐based polymer sources, their unique functional properties and their environmental impact, and addresses their role as sustainable alternatives. It discusses end‐of‐life options, including composting and anaerobic digestion for renewable energy.
Sabina Kolbl Repinc, Blaž Stres, Mirica Karlovits, Igor Karlovits, Petra Jerič, Ondrej Panák, Anja Verbič, Blaž Likozar, Uroš Novak   +8 more
wiley   +1 more source

Phase transitions in the early Universe: Impacts on BBN and CMB observables

Physical Review D
We explore the effects of low-scale cosmological first-order phase transitions (PTs) on big bang nucleosynthesis (BBN) and cosmic microwave background (CMB) anisotropies and distortions. We examine two scenarios: the PT energy acts as additional background energy, modifying the expansion history; and serves as energy injection into the baryon-photon ...
Rui Xu, Jiachen Lu, Shihao Deng, Ligong Bian   +3 more
openaire   +2 more sources

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Four results on out-of-equilibrium 2PI simulations in 3+1 dimensions

Journal of High Energy Physics
We perform an analysis of a number of approximations and methods used in numerical simulations of real-time Kadanoff-Baym equations based on truncations of the 2PI effective action.
Anders Tranberg, Gerhard Ungersbäck
doaj   +1 more source

Primordial Irregularities in an Early Universe with Vacuum Phase Transitions [PDF]

, 1982
Kenji Tomita
openalex   +1 more source