Results 131 to 140 of about 3,197,248 (349)

Binary phase detector gain in bang-bang phase-locked loops with DCO jitter

, 2010
Bang-bang phase-locked loops (BBPLLs) are hard nonlinear systems due to the nonlinearity introduced by the binary phase detector (BPD). In the presence of jitter, the nonlinear loop is typically analyzed by linearizing the BPD and applying linear ...
Gleeson, James, Tertinek, Stefan, Orla Feely, Stefan Tertinek, James P. Gleeson, Feely, Orla   +5 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Moment Distributions of Phase Type [PDF]

, 2009
In this paper we prove that the class of distributions on the positive reals with a rational Laplace transform, also known as matrix-exponential distributions, is closed under formation of moment distributions. In particular, the results are hence valid for the well known class of phase-type distributions.
Bladt, Mogens, Nielsen, Bo Friis; id_orcid 0000-0001-9146-9733   +1 more
openaire  

A continuous multivariate exponential distribution that is multivariate phase type

A reliability model for a bivariate exponential distribution is extended to the multivariate case. The multivariate exponential distribution is then shown to be of multivariate phase type (MPH), and its MPH representation is derived.Markov chains ...
O'Cinneide, Colm A., Raftery, Adrian E.
core  

Surge-type glaciers: controls, processes and distribution

, 2015
Glacier surging is an internally triggered instability. Surge-type glaciers periodically alternate between long periods of slow flow (the quiescent phase) and short periods of fast flow (the surge phase). Surging yields down-glacier transport of mass and
Sevestre, Heïdi
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

The timing of the formation and usage of replicase clusters in S-phase nuclei of human diploid fibroblasts

, 1991
The sites of nascent DNA synthesis were compared with the distribution of the proliferating cell nuclear antigen (PCNA) in S-phase nuclei of human diploid fibroblasts (HDF) by two in vitro techniques.
Kill, IR, Campbell, KHS, Hutchison, CJ, Bridger, JM, Maldonado-Codina, G   +4 more
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Phase Selection Method for 10 kV Three-Core Cables Under Single-Phase Grounding Fault Transient Based on Surface Magnetic Field Sensing

Sensors
Single-phase grounding is the dominant fault type in urban power distribution networks. Because the total magnetic flux would not change around the cable under a single-phase grounding fault, ferromagnetic zero-sequence current sensors cannot distinguish
Hang Wang, Tianhu Weng, Wenfang Ding, Shuai Yang, Zheng Xiao, Hang Li, Jun Chen   +6 more
doaj   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source