Results 61 to 70 of about 1,320 (265)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Dynamic load shedding and system restoration using wide area distribution management system

IET Generation, Transmission & Distribution
The demand for electric power has consistently been on the rise, owing to urbanisation and technological improvements. On the generation side, renewable sources have been favoured over their polluting, exhaustible, non‐renewable counterparts.
Jennie Angela Jose Shirley, Harini Manivelan, Prashant Khare, Maddikara Jaya Bharata Reddy   +3 more
doaj   +1 more source

Inverter Model Validation and Calibration Using Phasor Measurement Unit Data

IEEE Access
As the penetration of inverter-based renewable energy resources increases in the power grid, especially at the distribution and microgrid levels, the need to accurately represent them in planning studies increases as well.
Shuchismita Biswas, Francis Tuffner, Jim Follum, Todd Wall   +3 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

A Synchrophasor Based Optimal Voltage Control Scheme with Successive Voltage Stability Margin Improvement

Applied Sciences, 2016
This paper proposes an optimal control scheme based on a synchronized phasor (synchrophasor) for power system secondary voltage control. The framework covers voltage stability monitoring and control.
Heng-Yi Su, Yi-Chung Chen, Yu-Liang Hsu
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Protection of Microgrid Feeders Using Impedance Angle Analysis Assisted by Synchrophasor Units [PDF]

Journal of Renewable Energy and Environment
The healthy operation of a microgrid is a more challenging task due to the inclusion of various distribution generation (DG) sources. The incorporation of a grid with various distributed sources alters the radial structure of the network, making it ...
Sunil Kumar, Ikbal Ali, Anwar Siddiqui
doaj   +1 more source

Thévenin Equivalent Parameter Adaptive Robust Estimation Considering the Erroneous Measurements of PMU

Energies, 2020
Parameter estimation based on the measurement data of the phasor measurement unit (PMU) is an important approach for identifying the Thévenin equivalent parameters (TEPs) of power systems. However, in the process of acquiring or transmitting data in PMU,
Anan Zhang, Wenting Tan, Ming Cheng, Wei Yang   +3 more
doaj   +1 more source

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Performance Analysis of Generator Dynamic State Estimation under Uncertain Measurement

Zhongguo dianli, 2020
Random errors are unavoidable in phasor measurement unit (PMU), and the PMU measurement data may be uncertain in actual power system, such as delay, reordering or even missing.
Jingbo ZHAO, Zhinong WEI, Hanwen WANG, Bing XIE, Mei HUANG, Xia MENG   +5 more
doaj   +1 more source