Results 71 to 80 of about 13,164 (284)
FEBS Letters, EarlyView.This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva +5 more
wiley +1 more source
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Energies, 2018 To address the issue that the phasor measurement units (PMUs) of wide area measurement system (WAMS) are not sufficient for static state estimation in most existing power systems, this paper proposes a mixed power system weighted least squares (WLS ...
Tao Jin, Xueyu Shen
doaj +1 more source
Technique for pre-compliance testing of phasor measurement units [PDF]
International Journal of Electrical Power & Energy Systems, 2018 Abstract This paper introduces a technique for ‘pre-compliance’ testing of Phasor Measurement Units (PMUs) against the dynamic requirements of the IEEE C37.118.1-2014 standard, which include dynamic and steady-state test scenarios. The tests described are a necessary, but not complete, requirement for passing the IEEE standard and quickly highlight ...
Brogan, Paul V. +5 more
openaire +3 more sources
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Impacts of subsynchronous and supersynchronous frequency components on synchrophasor measurements
Journal of Modern Power Systems and Clean Energy, 2016 Phasor measurement units (PMU) are playing an increasingly important role in power system dynamic security monitoring and control. However, the wide-area deployments of the renewable energy sources and the high voltage direct current (HVDC) transmission ...
Hao Liu +7 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source
A Multi-Objective Robust State Estimator for Systems Measured by Phasor Measurement Units
IEEE Access, 2018 Conventional state estimators, such as the weighted least squares estimator, have been widely employed for state estimation in power systems. However, these methods have difficulty addressing the leverage effect and rejecting erroneous measurements ...
Manyun Huang +5 more
doaj +1 more source