Results 121 to 130 of about 1,558,016 (310)

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, EarlyView.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Aspirantura (PhD Education) in Economic Sciences: PFUR Experience

Vestnik RUDN. International Relations, 2012
In the light of modern approaches to education in the Russian Federation and in connection with the transition of aspirantura (PhD education) to new graduate school standards the experience of PhD training in economic fields at the Peoples' Friendship ...
I V Lazanyuk
doaj  

INTEGRATED «ACADEMIC MASTER'S - PHD» EDUCATIONAL PROGRAMS

Высшее образование в России, 2016
We propose the concept of integrating programs of the second and third levels of higher education and creating exclusive educational systems «Academic Master's program - postgraduate school» on this basis. The purpose of such systems is to provide systematic targeted training of highly qualified experts (holders of Candidate of Sciences degree) for ...
Boris I. Bednyi, Oleg A. Kuzenkov
openaire   +1 more source

Bifunctional Artificial Enzymes‐Loaded Microgels With LOX‐ and CAT‐Like Activities for Metabolic Reprogramming and Scarless Wound Repair

Advanced Science, EarlyView.
A bifunctional lactate oxidase‐like and catalase‐like artificial enzyme (Metazyme) is integrated into a rod‐shaped microgel (MetaRgel) to enable cascade lactate oxidation and oxygen regeneration. By reprogramming the wound metabolic microenvironment, MetaRgel alleviates excessive lactate accumulation, oxidative stress, hypoxia, and inflammation ...
Yongyuan Kang, Pai Peng, Liang Song, Qiaoxuan Wang, Zilong Zhong, Dongchao Qiu, Yunfan Liu, Kefei Zhao, Xiaofei Dong, Changyou Gao   +9 more
wiley   +1 more source

‘Enlightened change agents with leadership skills’: A scoping review of competency-based curricula in public health PhD education

Cogent Education
There is growing momentum for PhD curricula to move away from traditional apprenticeship models and to adopt competency-based education models. The objectives of this study were to identify key drivers for adopting competency-based curricula during PhD ...
Noreen O’Leary, Ciarán McCarthy, Mary Clarke   +2 more
doaj   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Exploring Researcher Motivation: Implications for PhD Education

, 2016
As Cuthbert and Molla (2015, p. 33) argue, “[c]ontemporary higher education (HE) systems function within a political context of high optimism about the transformative potential of knowledge for individuals and for national economies.” “Knowledge economy optimism” is prevalent across Europe, North America, South East Asia, and China, as well as ...
Robyn Barnacle, Denise Cuthbert, Richard Laurie   +2 more
openaire   +2 more sources

Methylglyoxal Accumulation is Associated with Brain Inflammation after Myocardial Infarction with Sex and Regional Differences

Advanced Science, EarlyView.
This study identifies that methylglyoxal may play an important role in heart‐brain interactions after myocardial infarction. Myocardial infarction leads to increased levels of methylglyoxal‐derived advanced glycation end‐products (MG‐H1) in the brain of mice, which is associated with loss of blood‐brain barrier integrity and neuroinflammation ...
Ramis Ileri, Xixi Guo, Erik J. Suuronen
wiley   +1 more source

Подготовка докторов философии в области образования: опыт ведущих университетов мира [PDF]

, 2016
PhD in education training organization in the United States and United Kingdom leading universities is enlightened in the article; content of doctoral programs coursework is revealed; different forms of PhD in education training organization are ...
Регейло, Ірина, Сисоєва, Світлана Олександрівна   +1 more
core  

In Situ Electrochemical Activation of Pseudo‐Layered NbS3 via Interlayer Expansion and Dual Redox for High Mg‐Ion Storage

Advanced Science, EarlyView.
A quasi‐1D pseudo‐layered NbS3 cathode for magnesium‐ion batteries can be created through electrochemically induced interlayer expansion. The widened ion‐transport channels enable fast magnesium ion diffusion and unlock coupled cationic‐anionic redox chemistry.
Pengcheng Jing, Atsushi Inoishi, Chengcheng Zhao, Eiichi Kobayashi, Peng Ren, Isaac Abrahams, Duncan H. Gregory   +6 more
wiley   +1 more source