Results 111 to 120 of about 30,643 (283)
PharmaceuticalsNew Psychoactive Substances (NPS) are modifying the drug scenario worldwide and have become a public health concern because of their toxicological profiles and their harmful physical/psychological effects.
Maria Pepe +6 more
doaj +1 more source
Frontiers in Psychiatry, 2010 Phencyclidine (PCP) induces a behavioural syndrome in rodents that bears remarkable similarities to some of the core symptoms observed in schizophrenic patients, among those cognitive deficits.
John P Redrobe +2 more
doaj +1 more source
The effects of zinc sulfate on ethyl glucuronide immunoassay urine testing [PDF]
, 2016 Published research in the Journal of Analytical Toxicology and the American Society for Clinical Pathology has confirmed that the presence of Zinc Sulfate in adulterated urine samples can influence the testing results using EMIT and ELISA immunoassay ...
Cawley, Shanna Marie
core +1 more source
Role of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in the rat [PDF]
, 2009 YesRationale: 5-HT receptor mechanisms have been suggested to mediate improvements in cognition in schizophrenia. Aim: To investigate the involvement of 5-HT receptor mechanisms in sub-chronic PCP-induced reversal learning deficits in female rats, a task
McLean, Samantha L. +3 more
core +1 more source
Chlorinated Paracyclophanes: Composition Analysis and Direct Metal‐Free Alkylation with n‐BuLi
European Journal of Organic Chemistry, EarlyView.A transition‐metal‐free alkylation of pseudo‐para dichloro[2.2]paracyclophane (Cl2‐PCP) is reported, utilizing the purified pseudo‐para isomer and n‐butyllithium (BuLi). Optimization with the chelating agent TMEDA and refluxing n‐heptane significantly boosted selectivity and reaction rate, providing the dialkylated product in 22% isolated yield.
Davide Frigatti +3 more
wiley +1 more source
Blockade of voltage-gated K+ currents in rat mesenteric arterial smooth muscle cells by MK801
Journal of Pharmacological Sciences, 2015 MK801 (dizocilpine), a phencyclidine (PCP) derivative, is a potent noncompetitive antagonist of the N-Methyl-D-aspartate receptor (NMDAr). Another PCP derivative, ketamine, was reported to block voltage-gated K+ (Kv) channels, which was independent of ...
Jeong Min Kim +8 more
doaj +1 more source
Role of Thalamic Projection in NMDA Receptor-Induced Disruption of Cortical Slow Oscillation and Short-Term Plasticity [PDF]
, 2011 NMDA receptor (NMDAR) antagonists, such as phencyclidine, ketamine or dizocilpine (MK-801) are commonly used in psychiatric drug discovery in order to model several symptoms of schizophrenia, including psychosis and impairments in working memory.
Tamás Kiss +6 more
core +2 more sources
Ambient technology in epilepsy clinical practice
Epilepsia Open, EarlyView.Abstract The utilization of large language model‐based artificial intelligence (AI) in the field of neurology has gained attention as a viable tool to enhance and assist providers with processes ranging from scheduling patients to providing preliminary interpretations of testing results, pending orders, and documenting encounters. Epileptologists could
Haania Kakwan +3 more
wiley +1 more source
Journal of Pharmacological Sciences, 2013 We have demonstrated previously that the ketamine-induced discriminative stimulus effect is likely to reflect the phencyclidine-like psychotomimetic effects. Therefore, the present study was designed to investigate the effects of the antipsychotics and 5-
Kazumi Yoshizawa +7 more
doaj +1 more source
Earthquake Engineering &Structural Dynamics, EarlyView.ABSTRACT This article presents a capacity‐based assessment procedure for beam–column (b–c) joints of reinforced concrete frames with floor slabs and transverse beams. The procedure extends a previously proposed assessment methodology for determining the hierarchy of strengths and the sequence of events in symmetrically reinforced planar b–c joints.
Patricio Quintana Gallo +3 more
wiley +1 more source