Results 211 to 220 of about 30,643 (283)

Supporting General Practitioners to Deprescribe Benzodiazepines and Z‐Drugs in Primary Care: Findings From a Modified Delphi Study

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 4, April 2026.
ABSTRACT Long‐term use of benzodiazepines and Z‐drugs (collectively known as benzodiazepine receptor agonists; BZRAs) is associated with a range of adverse effects including dependence and withdrawal on stopping or reducing the dose. Deprescribing is recommended to improve patient outcomes and reduce medication‐related harm, but its implementation in ...
Erin Oldenhof, Megan Pisegna, Mark Horowitz, Hester Wilson, Karen Gelb, Stephen Trumble, Catherine Andronis, Marguerite Tracy, Nicholas A. Zwar, Andrew Mau, Anna Chapman, Petra K. Staiger   +11 more
wiley   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

British Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen, Declan P. McKernan, John P. Kelly   +2 more
wiley   +1 more source

Basal ganglia deep brain stimulation restores cognitive flexibility and exploration-exploitation balance disrupted by NMDA-R antagonism. [PDF]

Nat Commun
Asch N, Rahamim N, Morozov A, Werner-Reiss U, Israel Z, Paz R, Bergman H.   +6 more
europepmc   +1 more source

Longitudinal Clinical Outcomes of Tissue‐Level Dental Implants in a Periodontal Practice: A Retrospective Study

Clinical Implant Dentistry and Related Research, Volume 28, Issue 2, April 2026.
ABSTRACT Objectives This study aimed to evaluate the 28‐year cumulative success and survival rates of tissue‐level implants placed by a periodontist in Taiwan. Materials and Methods In this retrospective cohort study, 685 tissue‐level implants placed in 199 patients between 1996 and 2024 were analyzed.
Hongmin Lai, Ming‐Tsuen Lin, Ting‐Yu Lin, Sam Li‐Sheng Chen, Tony Hsiu‐Hsi Chen, Amy Ming‐Fang Yen   +5 more
wiley   +1 more source

New-Onset Psychosis in a Person with Parkinson's Disease after "Horny Goat Weed" Use. [PDF]

Mov Disord Clin Pract
Deliz JR, Manoocheri K, Larson DN, Bega D.   +3 more
europepmc   +1 more source

Burden of Obesity in India: Need for Policy Changes to Attain Highest Possible Level of Health and Well‐Being

Clinical Obesity, Volume 16, Issue 2, April 2026.
ABSTRACT The rise in obesity rates in India in the past 3–4 decades is alarming and obesity management needs transformation. A significant barrier is that obesity is often viewed in India as a lifestyle condition rather than a chronic disease, despite broad international recognition of this status.
Sanjay Kalra, Jothydev Kesavadev, Ramen Goel, Muffazal Lakdawala, Vinayak Agrawal, Neena Malhotra, Nitin Kapoor, Neeta Deshpande, Ankush Desai, Viswanathan Mohan, Rajesh Khadgawat, Balram Sharma   +11 more
wiley   +1 more source

The Blurred Lines Between New Psychoactive Substances and Potential Chemical Weapons. [PDF]

Toxics
Valenzuela-Tapia LN, Quintul CA, Rubio-Concha ND, Toledo-Ríos L, Salas-Kuscevic C, Leisewitz AV, Cámpora-Oñate P, Campanini-Salinas J.   +7 more
europepmc   +1 more source

Whisking Behaviour Reveals Stronger Evidence of Habituation in Homozygous Reeler Mice Compared to Controls

Genes, Brain and Behavior, Volume 25, Issue 2, April 2026.
In the habituation task, locomotion speed, whisker angular position and whisker spread decreased between the first two consecutive sessions in all mice, suggesting that the animals were less focused on sampling the area as they got more familiar with the environment.
Ugne Simanaviciute, Aybeniz Ece Cetin, Julien Guy, Helen Tams, Jochen Staiger, Robyn A. Grant   +5 more
wiley   +1 more source

From model psychosis to rapid antidepressant: a historical and conceptual review of ketamine's psychiatric history. [PDF]

Ther Adv Psychopharmacol
Cabrera Abreu C, Biorac A, Baldessarini RJ, Vázquez GH.   +3 more
europepmc   +1 more source

The Use of Triage in Primary Care in the UK: An Integrative Review and Narrative Synthesis

Journal of Advanced Nursing, Volume 82, Issue 4, Page 2736-2765, April 2026.
ABSTRACT Aims To examine the use of triage systems in primary care in the UK. Design Integrative literature review and narrative synthesis. Data Sources PubMed, EMBASE, CINAHL and Cochrane Library were searched in October 2024. Methods An integrative literature review was conducted following Whittemore and Knafl's (2005) five‐step process.
Han Nah Park, Kyeongmin Lee, Carolyn Wallace   +2 more
wiley   +1 more source