Results 91 to 100 of about 7,416 (225)

Recent Contributions of Organic Synthesis to Forensic Science

ChemPlusChem, Volume 91, Issue 2, February 2026.
Forensic science is a multidisciplinary field that plays a vital role in providing scientific evidence for criminal investigations. This review highlights advances and opportunities at the interface between organic synthesis and forensic science, with applications in drug identification, forensic toxicology, and latent fingerprint detection and ...
Gustavo dos Santos Martins, Mariana dos Santos Dupim, Rodrigo Garcia Agostinho, Fernanda Gadini Finelli   +3 more
wiley   +1 more source

Anticancer metallohelices: nanomolar potency and high selectivity [PDF]

, 2015
A range of new helicate-like architectures have been prepared via highly diastereoselective self-assembly using readily accessible starting materials. Six pairs of enantiomers [Fe2L3]Cl4.nH2O (L = various bidentate ditopic ligands NN–NN) show very good ...
Allison, Allison, Andrews, Brabec, Brabec, Bunz, Cao, Cardo, Daborn, Deeth, Deeth, Dunn, Eggert, Faulkner, Grimme, Hanahan, Howson, Howson, Howson, Howson, Howson, Kaner, Kennedy, Kennedy, Kerckhoffs, Klamt, Lee, Lehn, Li, Malina, Malina, Malina, Meacham, Moffat, Neese, Pathak, Persidis, Reynolds, Richards, Sams-Dodd, Schmidt, Seredyuk, Soussi, Swinney, Tait, Verheul, Yu   +46 more
core   +1 more source

Organopalladium compound 7b targets mitochondrial thiols and induces caspase-dependent apoptosis in human myeloid leukemia cells [PDF]

, 2013
The advances in the treatment of chronic myeloid leukemia (CML) during the last years were also accompanied by the development of evading strategies by tumor cells, resulting in chemotherapy resistance in some patients. Patented organopalladium compounds
Caires, A. C. F., Moraes, V. W. R., Paredes-Gamero, Edgar Julian, Rodrigues, T.   +3 more
core   +2 more sources

“ Thioureidopeptide”: Novel Synthon for the Synthesis of N, N′, N″-Trisubstituted Guanidinopeptide Mimics [PDF]

, 2016
The synthesis of N α-protected N,N′,N″-trisubstituted guanidinopeptide mimic molecules suitably decorated in peptide backbone has been delineated in one pot employing HgCl2 as a desulphurizing agent.
Girish Prabhu, ., Hosamani Basavaprabhu, ., Krishnamurthy, M., Nageswara Rao, P., Sureshbabu, V.V.   +4 more
core   +1 more source

Recent Advances in Methamphetamine Neurotoxicity Mechanisms and Its Molecular Pathophysiology

Behavioural Neurology, 2015
Methamphetamine (METH) is a sympathomimetic amine that belongs to phenethylamine and amphetamine class of psychoactive drugs, which are widely abused for their stimulant, euphoric, empathogenic, and hallucinogenic properties. Many of these effects result
Shaobin Yu, Ling Zhu, Qiang Shen, Xue Bai, Xuhui Di   +4 more
doaj   +1 more source

Pharmacology of novel psychoactive substances [PDF]

, 2016
This PhD work consists of an in vitro and in vivo part. In the in vivo part, we investigated the role of dopamine in the acute clinical effects of 3,4-methylenedioxymethamphetamine (MDMA, “ecstasy”) in healthy human subjects.
Rickli, Anna
core   +1 more source

Exploring the structural and electronic characteristics of phenethylamine derivatives: a density functional theory approach

Journal of Engineering and Applied Science
Accurate structure elucidation of biologically active molecules is crucial for designing and developing new drugs, as well as for analyzing their pharmacological activity.
Arya Bhaskarapillai, Sachidanandan Parayil, Jayasudha Santhamma, Deepa Mangalam, Velupillai Madhavan Thampi Anandakumar   +4 more
doaj   +1 more source

Palladacycles catalyse the oxidation of critical thiols of the mitochondrial membrane proteins and lead to mitochondrial permeabilization and cytochrome c release associated with apoptosis [PDF]

, 2009
Permeabilization of the mitochondrial membrane has been extensively associated with necrotic and apoptotic cell death. Similarly to what had been previously observed for B16F10-Nex2 murine melanoma cells.
Caires, Antonio C. F., Faria, Priscila A., Nantes, Iseli L., Paredes-Gamero, Edgar J., Rodrigues, Tiago, Santana, Debora P.   +5 more
core   +1 more source

Effects of lactic acid bacterial and chemical additives on the quality and biogenic amine production of oat silage at low temperature

Frontiers in Sustainable Food Systems
ObjectiveThe effects of low-temperature-resistant lactic acid bacteria (LAB) and chemical additives on the quality and biogenic amine production of oat (Avena sativa L.) silage stored at low temperature were investigated.MethodsThe Lactobacillus ...
Yuhan Huang, Tingting Jia
doaj   +1 more source

β2-Adrenergic Receptor Activation Suppresses the Rat Phenethylamine Hallucinogen-Induced Head Twitch Response: Hallucinogen-Induced Excitatory Post-synaptic Potentials as a Potential Substrate

Frontiers in Pharmacology, 2018
5-Hydroxytryptamine2A (5-HT2A) receptors are enriched in layers I and Va of the rat prefrontal cortex and neocortex and their activation increases the frequency of glutamatergic excitatory post-synaptic potentials/currents (EPSP/Cs) onto layer V ...
Gerard J. Marek, Gerard J. Marek, Brian P. Ramos   +2 more
doaj   +1 more source