Results 71 to 80 of about 7,416 (225)

Psychedelic Therapies for Comorbid Major Depressive Disorder and Chronic Pain: A Review of Putative Mechanisms of Action

open access: yesPharmacology Research &Perspectives, Volume 14, Issue 2, April 2026.
ABSTRACT Major Depressive Disorder (MDD) and chronic pain are independently debilitating conditions that frequently co‐occur. This comorbidity poses a significant clinical challenge, resulting in greater symptom severity, higher disability, and worse prognosis than either condition alone.
Jordana Kazdan   +2 more
wiley   +1 more source

New Unusual Alkaloids from the Ascidian

open access: yesNatural Product Communications, 2014
The MeOH extract of the ascidian Eudistoma vannamei was found to contain three novel compounds, the adenine alkaloid derivatives 9-[ N -(leucyl)-isoleucyl]-adenine ( 1 ) and 8-hydroxy-8-isopentyl-7,8-dihydroadenine ( 2 ), and the phenylalanine peptide ...
Antônia Torres Ávila Pimenta   +4 more
doaj   +1 more source

3-Cyano-4,6-diphenyl-2-(phenethylamino)pyridine

open access: yesMolbank, 2014
Novel synthesis of a 2-amino-3-cyano-2,6-diphenyl pyridine by a one-pot multi-component reaction of 1,3-diphenylpropane-1,3-dione, malononitrile and phenethylamine in the presence of N-hydroxybenzamide and zinc chloride has been reported.
Afsaneh Zonouzi   +4 more
doaj   +1 more source

Bisabolane type sesquiterpenes from a marine Didiscus sponge [PDF]

open access: yes, 2003
Two bisabolane type sesquiterpene phenols, (+)-curcuphenol (1) and (+)-curcudiol (2), were isolated from a Philippine marine sponge, Didiscus sp., in addition to b -sitosterol (3) and phenethylamine (4). The structures of the metabolites were established
Bugni, T. S.   +5 more
core  

Going Deep into the Surface Chemistry of Carbon Dots: Influence of Functional Groups on the Redox Abilities

open access: yesSmall, Volume 22, Issue 24, 27 April 2026.
The chemical structure of Carbon Dots (CDs) is still a mystery despite years of study. Herein, we show how CDs with a higher density of surface‐accessible amines display enhanced (photo)redox performance. Electrochemical and thermodynamic analyses confirmed the feasibility of electron transfer, while mechanistic investigations revealed that the ...
Laura Morbiato   +6 more
wiley   +1 more source

Development of a novel risk score reflecting the relative harm potential of synthetic cannabinoids based on prevalence estimates, well‐documented intoxication cases and basic pharmacological data

open access: yesAddiction, Volume 121, Issue 4, Page 870-882, April 2026.
Abstract Background and aims While the health hazards of synthetic cannabinoid receptor agonists (SCRAs) are often approximated using in vitro pharmacological parameters as surrogate, this approach fails to consider pharmacokinetic and pharmacodynamic complexity.
Michaela J. Sommer   +3 more
wiley   +1 more source

Neurochemical and Behavioral Profiling in Male and Female Rats of the Psychedelic Agent 25I-NBOMe

open access: yesFrontiers in Pharmacology, 2019
4-Iodo-2,5-dimethoxy-N-(2-methoxybenzyl)phenethylamine (25I-NBOMe), commonly called “N-Bomb,” is a synthetic phenethylamine with psychedelic and entactogenic effects; it was available on the Internet both as a legal alternative to lysergic acid ...
Cristina Miliano   +11 more
doaj   +1 more source

Novel Electrophilic and Photoaffinity Covalent Probes for Mapping the Cannabinoid 1 Receptor Allosteric Site(s) [PDF]

open access: yes, 2015
ACKNOWLEDGMENTS The work was supported by National Institutes of Health grants DA027113 and EY024717 to G.A.T. and DA09158 to A.M. A portion of this work was submitted in 2011 by A. Kulkarni in partial fulfillment of M.S.
Cascio, Maria G.   +12 more
core   +3 more sources

Daytime Sleepiness and Dispositional Optimism Are Related to Awake Bruxism Among Patients With Painful Temporomandibular Disorders

open access: yesJournal of Oral Rehabilitation, Volume 53, Issue 4, Page 833-842, April 2026.
Daytime sleepiness and dispositional optimism are related with awake bruxism among patients with painful temporomandibular disorders. ABSTRACT Objective Awake bruxism (AB) is a multifactorial condition that has been linked to several physiological and psychological factors.
Bachar Reda   +3 more
wiley   +1 more source

Novel Psychoactive Substances: : the pharmacology of stimulants and hallucinogens [PDF]

open access: yes, 2016
This is an Accepted Manuscript of an article published by Taylor & Francis in Expert Review of Clinical Pharmacology, on March 2016, available online at doi: : http://www.tandfonline.com/doi/full/10.1586/17512433.2016.1167597.There are increasing levels ...
Corkery JM   +11 more
core   +3 more sources

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