A molecular analysis of substituted phenylethylamines as potential microtubule targeting agents through in silico methods and in vitro microtubule-polymerization activity [PDF]
Scientific Reports, 2023 Natural phenethylamines are trace amine neurotransmitters associated with dopamine transmission and related illnesses such Parkinson’s disease, and addiction.
Isadora Rocha De Abreu +4 more
doaj +2 more sources
2-Phenethylamines in Medicinal Chemistry: A Review [PDF]
Molecules, 2023 A concise review covering updated presence and role of 2-phenethylamines in medicinal chemistry is presented. Open-chain, flexible alicyclic amine derivatives of this motif are enumerated in key therapeutic targets, listing medicinal chemistry hits and ...
Carlos T. Nieto +4 more
doaj +2 more sources
Unraveling the In Vitro Toxicity Profile of Psychedelic 2C Phenethylamines and Their N-Benzylphenethylamine (NBOMe) Analogues [PDF]
Pharmaceuticals, 2023 Mescaline derivative (2C phenethylamines) drugs have been modified by the introduction of a N-2-methoxybenzyl group to originate a new series of compounds with recognized and potent psychedelic effects, the NBOMe-drugs.
Daniel Martins +9 more
doaj +2 more sources
Receptor interaction profiles of novel N-2-methoxybenzyl (NBOMe) derivatives of 2,5-dimethoxy-substituted phenethylamines (2C drugs) [PDF]
Neuropharmacology, 2015 N-2-methoxybenzyl-phenethylamines (NBOMe drugs) are newly used psychoactive substances with poorly defined pharmacological properties. The aim of the present study was to characterize the receptor binding profiles of a series of NBOMe drugs compared with
Anna Rickli +2 more
exaly +3 more sources
Facile one-pot reduction of β-nitrostyrenes to phenethylamines using sodium borohydride and copper(II) chloride [PDF]
Beilstein Journal of Organic ChemistryPhenethylamines and phenylisopropylamines of scientific relevance can be prepared with a NaBH4/CuCl2 system in 10 to 30 minutes via reduction of substituted β-nitrostyrenes.
Laura D’Andrea, Simon Jademyr
doaj +2 more sources
Recreational Drug Overdose—Clinical Value of Toxicological Analysis [PDF]
ToxicsBackground: Toxicological analysis of patients with acute recreational drug poisoning can improve our understanding of substance use patterns, clinical symptoms, and improve treatment. Patient history alone may be incomplete or misleading.
Tobias Zellner +5 more
doaj +2 more sources
Toxicodynamic insights of 2C and NBOMe drugs – Is there abuse potential? [PDF]
Toxicology ReportsDrug use represents a prevalent and multifaceted societal problem, with profound implications for public health, social welfare, and economic stability.
Eva Gil-Martins +4 more
doaj +2 more sources
Veridentification and determination of 2,5-dimetoxy-4-bromophenethylamine (2C-B) in real sample by GC-MS methods and derivatization after SPE preparation [PDF]
Bulletin of Natural Sciences Research, 2022 The abuse of new psychoactive substances is attracting a lot of attention from the world public. There is an increasing use among young people, who are not aware of the harmful effects of this substances. Some of these substances may have been around for
Lukić Vera +2 more
doaj +1 more source
Biomedicines, 2022 The illicit drug market of novel psychoactive substances (NPSs) is expanding, becoming an alarming threat due to increasing intoxication cases and insufficient (if any) knowledge of their effects. Phenethylamine 2-chloro-4,5-methylenedioxymethamphetamine
Augusta Pisanu +9 more
doaj +1 more source
Sex and Gender Differences in the Effects of Novel Psychoactive Substances
Brain Sciences, 2020 Sex and gender deeply affect the subjective effects and pharmaco-toxicological responses to drugs. Men are more likely than women to use almost all types of illicit drugs and to present to emergency departments for serious or fatal intoxications. However,
Liana Fattore +3 more
doaj +1 more source