Results 11 to 20 of about 4,010 (219)

Psychedelic Therapies for Comorbid Major Depressive Disorder and Chronic Pain: A Review of Putative Mechanisms of Action. [PDF]

open access: yesPharmacol Res Perspect
ABSTRACT Major Depressive Disorder (MDD) and chronic pain are independently debilitating conditions that frequently co‐occur. This comorbidity poses a significant clinical challenge, resulting in greater symptom severity, higher disability, and worse prognosis than either condition alone.
Kazdan J, Ladha KS, Husain MI.
europepmc   +2 more sources

NBOMes–Highly Potent and Toxic Alternatives of LSD

open access: yesFrontiers in Neuroscience, 2020
Recently, a new class of psychedelic compounds named NBOMe (or 25X-NBOMe) has appeared on the illegal drug market. NBOMes are analogs of the 2C family of phenethylamine drugs, originally synthesized by Alexander Shulgin, that contain a N-(2-methoxy ...
Jolanta B. Zawilska   +2 more
doaj   +1 more source

Overview of the major classes of new psychoactive substances, psychoactive effects, analytical determination and conformational analysis of selected illegal drugs

open access: yesOpen Chemistry, 2021
The misuse of psychoactive substances is attracting a great deal of attention from the general public. An increase use of psychoactive substances is observed among young people who do not have enough awareness of the harmful effects of these substances ...
Lukić Vera   +4 more
doaj   +1 more source

Entactogens: How the Name for a Novel Class of Psychoactive Agents Originated

open access: yesFrontiers in Psychiatry, 2022
At first glance, it appears there is little difference between the molecular structures of methylenedioxymethamphetamine (MDMA), which has an N-methyl attached to its amino group, and methylenedioxyamphetamine (MDA), a primary amine that is recognized to
David E. Nichols
doaj   +1 more source

Population Survey Data Informing the Therapeutic Potential of Classic and Novel Phenethylamine, Tryptamine, and Lysergamide Psychedelics

open access: yesFrontiers in Psychiatry, 2020
IntroductionThe majority of contemporary psychedelic research has focused on ayahuasca, lysergic acid diethylamide, and psilocybin, though there are hundreds of novel psychedelic compounds that may have clinical utility.
James D. Sexton   +2 more
doaj   +1 more source

Effect of -NBOMe Compounds on Sensorimotor, Motor, and Prepulse Inhibition Responses in Mice in Comparison With the 2C Analogs and Lysergic Acid Diethylamide: From Preclinical Evidence to Forensic Implication in Driving Under the Influence of Drugs

open access: yesFrontiers in Psychiatry, 2022
In the last decade, the market for new psychoactive substances has been enriched by numerous psychedelic phenethylamines, which mimic the psychoactive effect of lysergic acid diethylamide (LSD).
Micaela Tirri   +13 more
doaj   +1 more source

Neurotoxic effects of hallucinogenic drugs 25H-NBOMe and 25H-NBOH in organotypic hippocampal cultures

open access: yesHeliyon, 2023
Introduction: NBOMes and NBOHs are psychoactive drugs derived from phenethylamines and have hallucinogenic effects due to their strong agonism to serotonin 5-HT2A receptors.
Larissa Marcely Gomes Cassiano   +4 more
doaj   +1 more source

Recent trends in analytical methods to determine new psychoactive substances in hair [PDF]

open access: yes, 2017
New Psychoactive Substances (NPS) belong to several chemical classes, including phenethylamines, piperazines, synthetic cathinones and synthetic cannabinoids.
García Algar, Oscar   +4 more
core   +1 more source

The varieties of the psychedelic experience: A preliminary study of the association between the reported subjective effects and the binding affinity profiles of substituted phenethylamines and tryptamines [PDF]

open access: yes, 2018
Classic psychedelics are substances of paramount cultural and neuroscientific importance. A distinctive feature of psychedelic drugs is the wide range of potential subjective effects they can elicit, known to be deeply influenced by the internal state of
Erowid, Earth   +6 more
core   +2 more sources

Recent changes in drug abuse scenarios : The new/novel psychoactive substances (NPS) phenomenon [PDF]

open access: yes, 2018
© 2018 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Peer ...
Schifano, Fabrizio
core   +2 more sources

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