Results 101 to 110 of about 37,355 (288)

Pharmacokinetics of Phenobarbital in Microenema Via Macy Catheter Versus Suppository [PDF]

open access: yes, 2016
ContextThe oral route is compromised for nearly all patients approaching death. When agitation, seizures, or other intractable symptoms occur, a quick, discreet, comfortable, and effective alternate route for medication delivery that is easy to ...
Macy, Brad   +2 more
core   +1 more source

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

open access: yesAdvanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis   +7 more
wiley   +1 more source

A phenobarbital overdose: a case report [PDF]

open access: yes, 2017
Background: Phenobarbital is a long-acting barbiturate, responsible for many cases of poisoning, from unintentional overdose or attempted suicide. We report a case of phenobarbital overdose in a patient with history of depression.
LICATA, Anna   +6 more
core  

Treatment of phenobarbital intoxication using hemodialysis in two dogs

open access: yes, 2020
Objective: To describe the use of hemodialysis in 2 dogs with severe clinical signs from phenobarbital intoxication. Series Summary: Two dogs ingested a toxic dose of phenobarbital, leading to severe neurological dysfunction and a comatose state.
Vigani, Alessio   +3 more
core   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

open access: yesAdvanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou   +4 more
wiley   +1 more source

Miniaturized Magnetic Tip Design for Endoluminal Vine Robot Navigation

open access: yesAdvanced Robotics Research, EarlyView.
A magnetic tip mount is designed for a miniaturized 7 mm soft‐growing vine robot to enable wireless magnetic steering and onboard imaging, while preserving a 3 mm working channel. The internal–external ring magnets design balances magnetic attachment with low eversion pressure. Experiments demonstrate ±90° steering, 34 mm bending radius, and successful
Andrea Yanez Trujillo   +4 more
wiley   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

open access: yesAdvanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen   +19 more
wiley   +1 more source

Cognitive Effects of Phenobarbital

open access: yes, 1996
Neurocognitive behavior in 9 children with various epilepsies was evaluated before and at 6 months after discontinuing phenobarbital monotherapy at the Department of Child Neurology, Instituto Nazionale Neurologico “Carlo Besta;” Milano ...
J Gordon Millichap
core   +1 more source

MASH Background Confers Enhanced Disease Susceptibility and Acetaminophen Toxicity in iPSC‐Derived Liver Organoids

open access: yesAdvanced Science, EarlyView.
This work establishes a novel method for generating multicellular liver organoids from control and MASH donor iPSCs. The model recapitulates several disease‐specific characteristics, with MASH donor‐derived organoids showing higher susceptibility. Lipidomic profiling of MASH organoids closely resembles MASH liver biopsies.
Ekta Minocha   +5 more
wiley   +1 more source

Phenobarbital exposure in human pregnancy

open access: yes, 2012
Includes bibliographical references (p. 58-62)Phenobarbital has been used to treat epilepsy for nearly a hundred years. Despite its long history of use, data on phenobarbital exposure during pregnancy is limited, and more information is needed to better ...
Salas, Elizabeth Lopez
core  

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