Results 91 to 100 of about 38,487 (282)

Self‐Sealing Microneedles Improve Precision and Reduce Reflux in Subretinal Cell Transplantation

Advanced Materials Technologies, EarlyView.
Ultrafine 49G microneedles enable subretinal delivery of induced pluripotent stem cell‐derived retinal pigment epithelial cells through a 50 µm outer diameter tip. Compared with conventional 38G microcannulas, these microneedles reduce cell suspension reflux in a rabbit model, highlighting the potential of microinvasive delivery instruments to improve ...
Jared Ching, Hinako Ichikawa, Aya Motoyoshi, Shin Tanaka, Liam Morrow, Satoshi Shirae, Noriko Sakai, Shohei Kitahata, Michiko Mandai, Kazuaki Kadonosono   +9 more
wiley   +1 more source

Phenobarbital influence on neuromuscular block produced by rocuronium in rats Influência do fenobarbital no bloqueio neuromuscular produzido pelo rocurônio em ratos

Acta Cirúrgica Brasileira, 2008
PURPOSE: To evaluate in vitro and in vivo neuromuscular blockade produced by rocuronium in rats treated with Phenobarbital and to determine cytochrome P450 and cytochrome b5 concentrations in hepatic microsomes.
Angélica de Fátima de Assunção Braga, Caroline Coutinho de Barcelos, Franklin Sarmento da Silva Braga, Samanta Cristina Antoniassi Fernandes, Yoko Oshima Franco, Mario Mantovani, Léa Rodrigues Simioni   +6 more
doaj   +1 more source

Tumbling Magnetic Microrobots for Targeted In Vivo Drug Delivery in the GI Tract

Advanced Robotics Research, EarlyView.
We introduce a microrobot design and integrated system for on‐demand targeted drug release in the gastrointestinal tract. The microrobot has an embedded magnet for actuation with external magnetic fields and is visualized in real time using ultrasound. It has two drug release ports sealed with a thermally sensitive wax. Local heating of the wax using a
Aaron C. Davis, Luis Carlos Sanjuan Acosta, Shubh P. Mehta, Baiyan Qi, Yang Yang, Luis Solorio, Craig J. Goergen, David J. Cappelleri   +7 more
wiley   +1 more source

Phenobarbital Influence On Neuromuscular Block Produced By Rocuronium In Rats.

, 2015
To evaluate in vitro and in vivo neuromuscular blockade produced by rocuronium in rats treated with Phenobarbital and to determine cytochrome P450 and cytochrome b5 concentrations in hepatic microsomes.
Barcelos, Caroline Coutinho de, Braga, Franklin Sarmento da Silva, Fernandes, Samanta Cristina Antoniassi, Braga, Angélica de Fátima de Assunção, Mantovani, Mario, Franco, Yoko Oshima, Simioni, Léa Rodrigues   +6 more
core  

Complex spectrum of phenobarbital effects in a mouse model of neonatal hypoxia-induced seizures [PDF]

, 2018
Seizures in neonates, mainly caused by hypoxic-ischemic encephalopathy, are thought to be harmful to the brain. Phenobarbital remains the first line drug therapy for the treatment of suspected neonatal seizures but concerns remain with efficacy and ...
Rodriguez-Alvarez, Natalia, Jimenez-Mateos, Eva M., Madden, Stephen F., Quinlan, Sean M. M., Henshall, David C., Molloy, Eleanor J., Boylan, Geraldine B.   +6 more
core   +1 more source

Does phenobarbital reduce the hospital length of stay for patients suffering from severe alcohol withdrawal? A retrospective comparison of phenobarbital to lorazepam infusionsKey Points

JAPhA Pharmacotherapy
Introduction: Data suggest that phenobarbital is as effective as benzodiazepines at managing withdrawal via its direct activation of the gamma-aminobutyric acid receptor and modulating glutamate-mediated stimulation of the N-methyl-D-aspartate receptor ...
Vicente J. Jaramillo, Meghan L. Fletcher, Toby Chiu, Preeyaporn Sarangarm   +3 more
doaj   +1 more source

Cross‐Scale Hierarchical Targeted Delivery System Based on Small‐Scale Magnetic Robots

Advanced Robotics Research, EarlyView.
This article reviews a cross‐scale hierarchical targeted delivery system that integrates magnetic continuum robots and magnetic microrobots. By combining rapid long‐range navigation with precise microscale targeting, the system overcomes key limitations of single‐scale approaches.
Junjian Zhou, Zhiqiang Chen, Yuanbiao Ma, Zhiqiang Tang, Qianqian Wang   +4 more
wiley   +1 more source

Serum alkaline phosphatase isoenzyme profiles in phenobarbital-treated epileptic dogs

BACKGROUND: Serum total alkaline phosphatase (AP) activity commonly is high in dogs receiving phenobarbital. Specific isoenzymes responsible for this increase are not well documented.

core   +1 more source

Understanding the role of microRNA expression in the response to phenobarbital toxicity in the rat [PDF]

, 2015
New chemical entities that humans and animals are likely to be exposed to are tested using various in vitro and in vivo toxicological assays to understand the potential for harm.
Osborne, Michael Craig
core   +1 more source

A Comparison of Parenteral Phenobarbital vs. Parenteral Phenytoin as Second-Line Management for Pediatric Convulsive Status Epilepticus in a Resource-Limited Setting

Frontiers in Neurology, 2019
Introduction: Pediatric convulsive status epilepticus (CSE) which is refractory to first-line benzodiazepines is a significant clinical challenge, especially within resource-limited countries.
Richard J. Burman, Richard J. Burman, Sally Ackermann, Alexander Shapson-Coe, Alvin Ndondo, Alvin Ndondo, Heloise Buys, Jo M. Wilmshurst, Jo M. Wilmshurst   +8 more
doaj   +1 more source