Phenobarbital Pharmacokinetics and Optimal Dosing of Phenobarbital
Pediatric Neurology Briefs, 2018 Researchers from the Baylor College of Medicine in Houston, TX, USA, conducted a retrospective population pharmacokinetic analysis of 355 patients ages less than 19 years of age in the inpatient setting who were initiated on intravenous or oral ...
Safiullah Shareef, Murtaza Nasir Ali
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Presumptive phenobarbital‐induced systemic lupus erythematosus in a domestic dog
Journal of Veterinary Internal Medicine, 2023 Case Description We describe a case of presumptive acquired systemic lupus erythematosus secondary to phenobarbital administration in a dog, which resolved with withdrawal of the drug.
Erin Phillips +5 more
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Toxic epidermal necrolysis caused by phenobarbital: a case report and literature review [PDF]
Frontiers in PharmacologyBackgroundToxic epidermal necrolysis (TEN) and Stevens-Johnson syndrome (SJS) are rare, life-threatening immunologic reactions. Previous relevant literature has provided limited information regarding this disease’s genetic susceptibility and management ...
Jie Cheng +7 more
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Phenobarbital Poisoning Case: Was It Preventable? [PDF]
, 2021 Phenobarbital-related poisoning may also occur with accidental or voluntary high doses of medications, as well as mispresentation of medications or drug doses by families and incorrect prescribing.
Songül Tomar Güneysu +11 more
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A Link between cholesterol levels and phenobarbital induction of cytochromes P450 [PDF]
, 2002 Squalestatin1 (SQ1), a potent inhibitor of squalene synthase produced a dose-dependent induction of cytochromes P450 CYP2H1 and CYP3A37 mRNAs in chicken hepatoma cells. The effect of SQ1 was completely reversed by 25-hydroxycholesterol.
Christoph Handschin +11 more
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Mechanistic studies of the phenobarbital-type induction of cytochromes P450 : role of AMP-activated protein kinase [PDF]
, 2007 Inside the liver cells there are sophisticated mechanisms that have evolved over millions of years to metabolize toxic substances, many of which are fat-soluble compounds making them difficult for the body to excrete.
Blättler, Sharon
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Microbial Metabolism and Inhibition Studies of Phenobarbital [PDF]
, 2012 Purpose: Screening scale studies were performed with eight cultures for their ability to metabolize phenobarbital, an antiepileptic, sedative, hypnotic and substrate for CYP 2C9 and 2C19.
Kavitha, K +3 more
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Crossroads between drug and energy metabolism : role of constitutive androstane receptor and AMP-activated kinase [PDF]
, 2010 Phenobarbital (PB) is a prototype inducer of genes encoding drug metabolizing enzymes including the cytochromes P450 (CYPs). Additionally, phenobarbital was found to repress genes that encode enzymes involved in gluconeogenesis such as ...
Harach, Taoufiq
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Conservation of signaling pathways of xenobiotic-sensing orphan nuclear receptors, chicken xenobiotic receptor, constitutive androstane receptor, and pregnane X receptor, from birds to humans [PDF]
, 2001 Chicken xenobiotic receptor, pregnane X receptor, and constitutive androstane receptor are orphan nuclear receptors that have recently been discovered to regulate drug- and steroid-mediated induction of hepatic cytochromes P450 (CYP).
Stockli, J. +5 more
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Ursodeoxycholic acid versus phenobarbital for cholestasis in the Neonatal Intensive Care Unit
BMC Pediatrics, 2018 Background Although neonates and young infants with cholestasis are commonly treated with either phenobarbital or ursodeoxycholic acid (ursodiol), there is no evidence that phenobarbital is effective for this indication.
Tamorah Lewis +2 more
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