Results 11 to 20 of about 55,162 (292)

Exposure to excess phenobarbital negatively influences the osteogenesis of chick embryos

Frontiers in Pharmacology, 2016
Phenobarbital is an antiepileptic drug that is widely used to treat epilepsy in a clinical setting. However, a long term of phenobarbital administration in pregnant women may produce side effects on embryonic skeletogenesis.
Yu Yan, Xin Cheng, Ren-hao Yang, He Li, Jian-long Chen, Zheng-lai Ma, Guang Wang, Manli Chuai, Xuesong Yang   +8 more
doaj   +1 more source

Interventions for treating hyperemesis gravidarum. [PDF]

, 2016
BACKGROUND: Hyperemesis gravidarum is a severe form of nausea and vomiting in pregnancy affecting 0.3% to 1.0% of pregnancies, and is one of the most common indications for hospitalization during pregnancy.
Abas, Adamczak, Arsenault, Bailit, Bondok, Bowen, Capp, Carlsson, Cox, Ditto, Dodds, Duggar, Eftekhari, Eliakim, Erez, Fell, Ferruti, Fischer-Rasmussen, Fletcher, Fletcher, Gadsby, Gawande, Gill, Goodwin, Gordon, Habek, He, Heazell, Holmgren, Ismail, Jarvis, Kashifard, Kelly, Klebanoff, Koren, Koren, Koren, Koren, Kramer, Lask, Ling, Liu, Magee, Maina, Maltepe, Maltepe, Mao, Mao, Matok, Matok, Matthews, Mazzotta, McCarthy, McCarthy, McParlin, Mella, Miller, Moran, Munch, Nelson-Piercy, Neri, Neutel, Niebyl, Oliveira, Ozgoli, Pasternak, Philip, Piwko, Pongrojpaw, Poursharif, Poursharif, Power, Price, Rhodes, Rhodes, Rosen, Safari, Safari, Saha, Shin, Shin, Sonkusare, Sullivan, Sullivan, Swallow, Tabatabaii, Tan, Tan, Tan, Tasci, Veciana, Wibowo, Willetts, Ylikorkala, Yost, Zhou, Ziaei   +96 more
core   +2 more sources

Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors

Brazilian Journal of Medical and Biological Research, 2001
The aim of the present study was to determine if phenobarbital affects the nociception threshold. Systemic (1-20 mg/kg) phenobarbital administration dose dependently induced hyperalgesia in the tail-flick, hot-plate and formalin tests in rats and in the ...
C.M. Yokoro, S.M.S. Pesquero, R.M.M. Turchetti-Maia, J.N. Francischi, M.A.K.F. Tatsuo   +4 more
doaj   +1 more source

C45 - Hydrogels oraux pH-sensibles contenant du phénobarbital pour une utilisation potentielle en pédiatrie

Journal Africain de Technologie Pharmaceutique et Biopharmacie, 2023
Introduction : Le but de l’étude était de développer des hydrogels oraux à base de chitosane pH- sensibles, capables de libérer le phénobarbital dans l'intestin grêle du nouveau-né.
Alphonse Rodrigue DJIBOUNE, Nicolas Anton, Sidy Mouhamed Dieng, Papa Mady Sy, Diouf Diouf, Gora Mbaye, Mamadou Soumboundou, Said Ennahar, Nadia Messaddeq, Thierry Vandamme, Mounibe Diarra   +10 more
doaj   +1 more source

Short-Term Neurodevelopmental Outcome in Term Neonates Treated with Phenobarbital versus Levetiracetam: A Single-Center Experience [PDF]

, 2019
BACKGROUND: Phenobarbital (PB) has been traditionally used as the first-line treatment for neonatal seizures. More recently, levetiracetam (LEV) has been increasingly used as a promising newer antiepileptic medication for treatment of seizures in ...
Barbagallo, M., Corsello, G., Falsaperla, R., Mauceri, L., Pavone, P., Pisani, F., Ruggieri, M., Vitaliti, G.   +7 more
core   +3 more sources

Evading Seizures: Phenobarbital Reintroduced as a Multifunctional Approach to End-of-Life Care

Case Reports in Oncology, 2022
The selected case study aimed to evaluate the role of phenobarbital as a drug of choice in end-of-life (EOL) settings. Phenobarbital is efficacious in management of EOL seizures and agitation, can be easily administered via different modes, and utilized ...
Helen Senderovich, Sarah Waicus, Keisa Mokenela   +2 more
doaj   +1 more source

Comparing the effect of intermittent diazepam and continuous phenobarbital in preventing recurrent febrile seizures among children under 6 years old: A systematic review and meta-analysis

Journal of Research in Medical Sciences, 2023
Background: Febrile convulsion (FC) is the most common and preventable seizure in children. This study aimed to assess the effectiveness of the diazepam and phenobarbital for preventing recurrent FC. Materials and Methods: In this systematic review study,
Leili Faraji Gavgani, Delara Laghousi, Parvin Sarbakhsh, Leila Jahangiri, Nafiseh Vahed, Sakineh Hajebrahimi   +5 more
doaj   +1 more source

Oral Loading of Phenobarbital to Achieve Therapeutic Effects in Pediatric Patients with Acute Repetitive Seizures [PDF]

Annals of Child Neurology, 2023
Purpose Intravenous phenobarbital has not been available at our institution since 2019. This study aimed to determine the effectiveness of oral phenobarbital loading at a dose of 15 to 20 mg/kg to achieve therapeutic serum levels and clinical seizure ...
Jemima Grace D. Fronda, Mel Michel G. Villaluz, Cristina M. Cruz-Urbi   +2 more
doaj   +1 more source

Time and dose-dependent effects of phenobarbital on the rat liver miRNAome. [PDF]

, 2013
In a previous study we had shown that treatment of male Fischer rats with exogenous chemicals for three months resulted in prominent, mode-of-action dependent effects on liver microRNA (miRNA) (Koufaris et al., 2012). Here we investigated how the effects
Currie, RA, Gooderham, NJ, Koufaris, C, Osborne, M, Wright, J   +4 more
core   +1 more source

Comparison between the Amount of Environmental Change and the Amount of Transcriptome Change.

PLoS ONE, 2015
Cells must coordinate adjustments in genome expression to accommodate changes in their environment. We hypothesized that the amount of transcriptome change is proportional to the amount of environmental change.
Norichika Ogata, Toshinori Kozaki, Takeshi Yokoyama, Tamako Hata, Kikuo Iwabuchi   +4 more
doaj   +1 more source