Results 11 to 20 of about 34,408 (289)
Phenobarbital and Suicidality: A Case Report [PDF]
Kerala Journal of Psychiatry, 2017 Phenobarbital is widely-used in primary care for the treatment of epilepsy, headache and insomnia in India. There are certain scenarios in which its use must be monitored closely.
Sreeja Sahadevan +4 more
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Phenobarbital Poisoning Case: Was It Preventable? [PDF]
, 2021 Phenobarbital-related poisoning may also occur with accidental or voluntary high doses of medications, as well as mispresentation of medications or drug doses by families and incorrect prescribing.
Songül Tomar Güneysu +5 more
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Mechanistic studies of the phenobarbital-type induction of cytochromes P450 : role of AMP-activated protein kinase [PDF]
, 2007 Inside the liver cells there are sophisticated mechanisms that have evolved over millions of years to metabolize toxic substances, many of which are fat-soluble compounds making them difficult for the body to excrete.
Blättler, Sharon
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A Link between cholesterol levels and phenobarbital induction of cytochromes P450 [PDF]
, 2002 Squalestatin1 (SQ1), a potent inhibitor of squalene synthase produced a dose-dependent induction of cytochromes P450 CYP2H1 and CYP3A37 mRNAs in chicken hepatoma cells. The effect of SQ1 was completely reversed by 25-hydroxycholesterol.
Christoph Handschin +7 more
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Comparison between the Amount of Environmental Change and the Amount of Transcriptome Change.
PLoS ONE, 2015 Cells must coordinate adjustments in genome expression to accommodate changes in their environment. We hypothesized that the amount of transcriptome change is proportional to the amount of environmental change.
Norichika Ogata +4 more
doaj +1 more source
Crossroads between drug and energy metabolism : role of constitutive androstane receptor and AMP-activated kinase [PDF]
, 2010 Phenobarbital (PB) is a prototype inducer of genes encoding drug metabolizing enzymes including the cytochromes P450 (CYPs). Additionally, phenobarbital was found to repress genes that encode enzymes involved in gluconeogenesis such as ...
Harach, Taoufiq
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Journal Africain de Technologie Pharmaceutique et Biopharmacie, 2023 Introduction : Le but de l’étude était de développer des hydrogels oraux à base de chitosane pH- sensibles, capables de libérer le phénobarbital dans l'intestin grêle du nouveau-né.
Alphonse Rodrigue DJIBOUNE +10 more
doaj +1 more source
Ursodeoxycholic acid versus phenobarbital for cholestasis in the Neonatal Intensive Care Unit
BMC Pediatrics, 2018 Background Although neonates and young infants with cholestasis are commonly treated with either phenobarbital or ursodeoxycholic acid (ursodiol), there is no evidence that phenobarbital is effective for this indication.
Tamorah Lewis +2 more
doaj +1 more source
Journal of Feline Medicine and Surgery Open Reports, 2022 Case summary A female neutered domestic longhair cat, aged 1 year and 5 months, presented with lymphadenomegaly and anaemia following therapy with phenobarbital for idiopathic epilepsy.
Michelle Walton-Clark +2 more
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Evading Seizures: Phenobarbital Reintroduced as a Multifunctional Approach to End-of-Life Care
Case Reports in Oncology, 2022 The selected case study aimed to evaluate the role of phenobarbital as a drug of choice in end-of-life (EOL) settings. Phenobarbital is efficacious in management of EOL seizures and agitation, can be easily administered via different modes, and utilized ...
Helen Senderovich +2 more
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