Results 21 to 30 of about 34,408 (289)

Oral Loading of Phenobarbital to Achieve Therapeutic Effects in Pediatric Patients with Acute Repetitive Seizures [PDF]

Annals of Child Neurology, 2023
Purpose Intravenous phenobarbital has not been available at our institution since 2019. This study aimed to determine the effectiveness of oral phenobarbital loading at a dose of 15 to 20 mg/kg to achieve therapeutic serum levels and clinical seizure ...
Jemima Grace D. Fronda, Mel Michel G. Villaluz, Cristina M. Cruz-Urbi   +2 more
doaj   +1 more source

Acute phenobarbital administration induces hyperalgesia: pharmacological evidence for the involvement of supraspinal GABA-A receptors

Brazilian Journal of Medical and Biological Research, 2001
The aim of the present study was to determine if phenobarbital affects the nociception threshold. Systemic (1-20 mg/kg) phenobarbital administration dose dependently induced hyperalgesia in the tail-flick, hot-plate and formalin tests in rats and in the ...
C.M. Yokoro, S.M.S. Pesquero, R.M.M. Turchetti-Maia, J.N. Francischi, M.A.K.F. Tatsuo   +4 more
doaj   +1 more source

Comparing the effect of intermittent diazepam and continuous phenobarbital in preventing recurrent febrile seizures among children under 6 years old: A systematic review and meta-analysis

Journal of Research in Medical Sciences, 2023
Background: Febrile convulsion (FC) is the most common and preventable seizure in children. This study aimed to assess the effectiveness of the diazepam and phenobarbital for preventing recurrent FC. Materials and Methods: In this systematic review study,
Leili Faraji Gavgani, Delara Laghousi, Parvin Sarbakhsh, Leila Jahangiri, Nafiseh Vahed, Sakineh Hajebrahimi   +5 more
doaj   +1 more source

Phenobarbital dyskinesia [PDF]

Postgraduate Medical Journal, 1978
Summary A patient was admitted to hospital following an overdose of phenobarbital. During her recovery she developed both chorea and torsion dystonia which could only be related to her high plasma phenobarbital levels.
openaire   +2 more sources

A novel panel of mouse models to evaluate the role of human pregnane X receptor and constitutive androstane receptor in drug response [PDF]

, 2008
The pregnane X receptor (PXR) and the constitutive androstane receptor (CAR) are closely related orphan nuclear hormone receptors that play a critical role as xenobiotic sensors in mammals.
Zevnik, Branko, Rode, Anja, Nicole Faust, Ross, Jillian, C. Roland Wolf, Nico Scheer, Scheer, Nico, Niehaves, Sandra, Sandra Niehaves, Faust, Nicole, Branko Zevnik, Wolf, C. Roland, Jillian Ross, Anja Rode   +13 more
core   +1 more source

Measurement of Blood Phenobarbital Concentration in Newborns Admitted to The NICU of Imam Reza Hospital and Receiving The Drug Via Intravenous Mode [PDF]

Asia Pacific Journal of Medical Toxicology
Introduction: Newborns may be treated with phenobarbital for many reasons. Because in each region, depending on different races and genetic factors, different pharmacokinetic conditions govern the drug.
Hamidreza Goldouzi, Ashraf Mohammadzadeh, Ahmadshah Farhat, Anahita Alizadeh, F Yazdanpanah, Tina Loghmani, Ezzat Khodashenas   +6 more
doaj   +1 more source

Human targeted phenobarbital presents a poor substrate of gut microbiome deciphering new drug targets beyond pharmacokinetic curbs

BMC Pharmacology and Toxicology, 2022
Background The gut microbiome, a new organ of the body, can potentially alter the pharmacokinetics of orally administered drugs through microbial enzymes.
Imran Mukhtar, Haseeb Anwar, Arslan Iftikhar, Heba E. Hashem, Qasim Ali, Farhan Siddique   +5 more
doaj   +1 more source

Evaluation of Intravenous Phenobarbital Pharmacokinetics in Critically Ill Patients With Brain Injury

Acta Medica Iranica, 2022
Phenobarbital is still one of the drugs of choice in managing patients with brain injury in the intensive care unit (ICU). However, the impact of acute physiological changes on phenobarbital pharmacokinetic parameters is not well studied.
Seyedeh Sana Khezrnia, Bita Shahrami, Mohammad Reza Rouini, Atabak Najafi, Hamid Reza Sharifnia, Sima Sadrai, Arezoo Ahmadi, Aarefeh Jafarzadeh kohneloo, Farhad Najmeddin, Mojtaba Mojtahedzadeh   +9 more
doaj   +1 more source

Stimulation of cholesterol 7α-hydroxylase by phenobarbital in two strains of rats

Journal of Lipid Research, 1972
The effect of phenobarbital administration on the in vitro activity of cholesterol 7α-hydroxylase was investigated in two strains of rats. In rats of the Wistar strain the daily injection of phenobarbital (100 mg/kg per day ip for 5 days) produced a 33 ...
S. Shefer, S. Hauser, E.H. Mosbach
doaj   +1 more source

Combination of antiseizure medications phenobarbital, ketamine, and midazolam reduces soman‐induced epileptogenesis and brain pathology in rats

Epilepsia Open, 2021
Objective Cholinergic‐induced status epilepticus (SE) is associated with a loss of synaptic gamma‐aminobutyric acid A receptors (GABAAR) and an increase in N‐methyl‐D‐aspartate receptors (NMDAR) and amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid ...
Lucille A. Lumley, Brenda Marrero‐Rosado, Franco Rossetti, Caroline R. Schultz, Michael F. Stone, Jerome Niquet, Claude G. Wasterlain   +6 more
doaj   +1 more source