Results 21 to 30 of about 29,842 (147)

Human targeted phenobarbital presents a poor substrate of gut microbiome deciphering new drug targets beyond pharmacokinetic curbs

BMC Pharmacology and Toxicology, 2022
Background The gut microbiome, a new organ of the body, can potentially alter the pharmacokinetics of orally administered drugs through microbial enzymes.
Imran Mukhtar, Haseeb Anwar, Arslan Iftikhar, Heba E. Hashem, Qasim Ali, Farhan Siddique   +5 more
doaj   +1 more source

Evaluation of Intravenous Phenobarbital Pharmacokinetics in Critically Ill Patients With Brain Injury

Acta Medica Iranica, 2022
Phenobarbital is still one of the drugs of choice in managing patients with brain injury in the intensive care unit (ICU). However, the impact of acute physiological changes on phenobarbital pharmacokinetic parameters is not well studied.
Seyedeh Sana Khezrnia, Bita Shahrami, Mohammad Reza Rouini, Atabak Najafi, Hamid Reza Sharifnia, Sima Sadrai, Arezoo Ahmadi, Aarefeh Jafarzadeh kohneloo, Farhad Najmeddin, Mojtaba Mojtahedzadeh   +9 more
doaj   +1 more source

Combination of antiseizure medications phenobarbital, ketamine, and midazolam reduces soman‐induced epileptogenesis and brain pathology in rats

Epilepsia Open, 2021
Objective Cholinergic‐induced status epilepticus (SE) is associated with a loss of synaptic gamma‐aminobutyric acid A receptors (GABAAR) and an increase in N‐methyl‐D‐aspartate receptors (NMDAR) and amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid ...
Lucille A. Lumley, Brenda Marrero‐Rosado, Franco Rossetti, Caroline R. Schultz, Michael F. Stone, Jerome Niquet, Claude G. Wasterlain   +6 more
doaj   +1 more source

Behavioral and structural changes in the hippocampus of wistar epileptic rats are minimized by acupuncture associated or not with phenobarbital

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2022
The aim of this study was to analyze the behavior and histopathological changes in the hippocampus of epileptic Wistar rats treated with acupuncture associated or not with phenobarbital.
T.C.C. Silva, A.A. N. Silva, Y.K.V. Serafim, V.A. Silva Júnior, E.R. Lima   +4 more
doaj   +1 more source

Investigation of cross-reactivity between phenobarbital and levetiracetam in children with epilepsy: A prospective, observational multicenter study

Epilepsy & Behavior Reports, 2023
Objectives: Pharmaceutical allergic reactions due to antiseizure medications (ASMs) are one of the major concerns in the management of patients. Finding an alternative ASM which does not cause allergic reactions and has acceptable effectiveness can be ...
Samane Rahimi, Bardia Danaei, Mohammad Mehdi Nasehi, Sasan Saket, Nazanin Farahbakhsh, Maryam Rajabnejad, Mohammad Mehdi Taghdiri   +6 more
doaj   +1 more source

Efficacy of phenobarbital is maintained after exposure to mild‐to‐moderate seizures in neonates

Epilepsia Open
To study the relationship between the delay in treatment and the efficacy of phenobarbital in neonates, we re‐analyzed data from the NEOLEV2 study. Continuous video EEG (cEEG) from patients treated with phenobarbital was reviewed by neurophysiologists ...
Cynthia Sharpe, Charlotte‐Rose Rennie‐Younger, Dug Yeo Han, Suzanne L. Davis, Mark Nespeca, Francesco Pisani, Jeffrey J. Gold, Gail E. Reiner, Sonya Wang, Richard H. Haas   +9 more
doaj   +1 more source

A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria

BMC Pediatrics, 2019
Background Acute seizures are common in pediatric cerebral malaria (CM), but usual care with phenobarbital risks respiratory suppression. We undertook studies of enteral levetiracetam (eLVT) to evaluate pharmacokinetics (PK), safety and efficacy ...
Gretchen L. Birbeck, Susan T. Herman, Edmund V. Capparelli, Fraction K. Dzinjalamala, Samah G. Abdel Baki, Macpherson Mallewa, Neema M. Toto, Douglas G. Postels, Joseph C. Gardiner, Terrie E. Taylor, Karl B. Seydel   +10 more
doaj   +1 more source

MicroRNA-122 down-regulation is involved in phenobarbital-mediated activation of the constitutive androstane receptor. [PDF]

PLoS ONE, 2012
Constitutive androstane receptor (CAR) is a nuclear receptor that regulates the transcription of target genes, including CYP2B and 3A. Phenobarbital activates CAR, at least in part, in an AMP-activated protein kinase (AMPK)-dependent manner. However, the
Ryota Shizu, Sawako Shindo, Takemi Yoshida, Satoshi Numazawa   +3 more
doaj   +1 more source

Antiepileptic Hypersensitivity Syndrome to Phenobarbital: A Case Report

Iranian Journal of Allergy, Asthma and Immunology, 2019
Phenobarbital is still one of the most commonly used medical treatments for different types of seizures. It has numerous different side-effects. Antiepileptic hypersensitivity syndrome (AHS) is a rare and potentially life-threatening adverse reaction to ...
Zahra Nafei, Nasrin Behniafard, Farzane Shefai   +2 more
doaj   +1 more source

Pharmacokinetic analysis of a phenobarbital overdose treated with urinary alkalinization alone

Toxicology Reports
Phenobarbital is a long-acting barbiturate used to treat alcohol withdrawal and epilepsy. Acute overdoses present with varying levels of central nervous system depression and large overdoses can be life threatening.
Justin Seltzer, Jeremy Hardin, Henrik Galust, Nathan Friedman, Bryan Corbett, Richard F. Clark   +5 more
doaj   +1 more source