Results 31 to 40 of about 38,487 (282)

Human targeted phenobarbital presents a poor substrate of gut microbiome deciphering new drug targets beyond pharmacokinetic curbs

BMC Pharmacology and Toxicology, 2022
Background The gut microbiome, a new organ of the body, can potentially alter the pharmacokinetics of orally administered drugs through microbial enzymes.
Imran Mukhtar, Haseeb Anwar, Arslan Iftikhar, Heba E. Hashem, Qasim Ali, Farhan Siddique   +5 more
doaj   +1 more source

Evaluation of Intravenous Phenobarbital Pharmacokinetics in Critically Ill Patients With Brain Injury

Acta Medica Iranica, 2022
Phenobarbital is still one of the drugs of choice in managing patients with brain injury in the intensive care unit (ICU). However, the impact of acute physiological changes on phenobarbital pharmacokinetic parameters is not well studied.
Seyedeh Sana Khezrnia, Bita Shahrami, Mohammad Reza Rouini, Atabak Najafi, Hamid Reza Sharifnia, Sima Sadrai, Arezoo Ahmadi, Aarefeh Jafarzadeh kohneloo, Farhad Najmeddin, Mojtaba Mojtahedzadeh   +9 more
doaj   +1 more source

Phenobarbital Therapy for Alcohol Withdrawal [PDF]

, 2021
For the treatment of alcohol withdrawal syndrome (AWS), phenobarbital works differently than benzodiazepines. Benzodiazepines activate only gamma-aminobutyric acid (GABA) whereas phenobarbital has the additional mechanism of inhibiting glutamate ...
Alcenius, Gay, Dressel, R.J., Zastrow, Karen, Muller, Erin, Foster, Mariah   +4 more
core   +1 more source

Combination of antiseizure medications phenobarbital, ketamine, and midazolam reduces soman‐induced epileptogenesis and brain pathology in rats

Epilepsia Open, 2021
Objective Cholinergic‐induced status epilepticus (SE) is associated with a loss of synaptic gamma‐aminobutyric acid A receptors (GABAAR) and an increase in N‐methyl‐D‐aspartate receptors (NMDAR) and amino‐3‐hydroxy‐5‐methyl‐4‐isoxazolepropionic acid ...
Lucille A. Lumley, Brenda Marrero‐Rosado, Franco Rossetti, Caroline R. Schultz, Michael F. Stone, Jerome Niquet, Claude G. Wasterlain   +6 more
doaj   +1 more source

Phenobarbital enhanced genotoxicity of ochratoxin A [PDF]

, 1996
Phenobarbital enhanced genotoxicity of ochratoxin
Monje, Marie-Carmen, Pinelli, Eric, El Adlouni, Chakib, Marty, Jean-Louis, Grosse, Yann, Pfohl-Leszkowicz, Annie   +5 more
core   +1 more source

Behavioral and structural changes in the hippocampus of wistar epileptic rats are minimized by acupuncture associated or not with phenobarbital

Arquivo Brasileiro de Medicina Veterinária e Zootecnia, 2022
The aim of this study was to analyze the behavior and histopathological changes in the hippocampus of epileptic Wistar rats treated with acupuncture associated or not with phenobarbital.
T.C.C. Silva, A.A. N. Silva, Y.K.V. Serafim, V.A. Silva Júnior, E.R. Lima   +4 more
doaj   +1 more source

Phenobarbital for Neonatal Seizures: Response Rate and Predictors of Refractoriness [PDF]

, 2016
Background Phenobarbital is the first-line choice for neonatal seizures treatment, despite a response rate of approximately 45%. Failure to respond to acute anticonvulsants is associated with poor neurodevelopmental outcome, but knowledge on predictors ...
Spagnoli C., Pelosi A., Seri S., Pavlidis E., Pisani F., Mazzotta S.   +5 more
core   +2 more sources

Investigation of cross-reactivity between phenobarbital and levetiracetam in children with epilepsy: A prospective, observational multicenter study

Epilepsy & Behavior Reports, 2023
Objectives: Pharmaceutical allergic reactions due to antiseizure medications (ASMs) are one of the major concerns in the management of patients. Finding an alternative ASM which does not cause allergic reactions and has acceptable effectiveness can be ...
Samane Rahimi, Bardia Danaei, Mohammad Mehdi Nasehi, Sasan Saket, Nazanin Farahbakhsh, Maryam Rajabnejad, Mohammad Mehdi Taghdiri   +6 more
doaj   +1 more source

Efficacy of phenobarbital is maintained after exposure to mild‐to‐moderate seizures in neonates

Epilepsia Open
To study the relationship between the delay in treatment and the efficacy of phenobarbital in neonates, we re‐analyzed data from the NEOLEV2 study. Continuous video EEG (cEEG) from patients treated with phenobarbital was reviewed by neurophysiologists ...
Cynthia Sharpe, Charlotte‐Rose Rennie‐Younger, Dug Yeo Han, Suzanne L. Davis, Mark Nespeca, Francesco Pisani, Jeffrey J. Gold, Gail E. Reiner, Sonya Wang, Richard H. Haas   +9 more
doaj   +1 more source

A clinical trial of enteral Levetiracetam for acute seizures in pediatric cerebral malaria

BMC Pediatrics, 2019
Background Acute seizures are common in pediatric cerebral malaria (CM), but usual care with phenobarbital risks respiratory suppression. We undertook studies of enteral levetiracetam (eLVT) to evaluate pharmacokinetics (PK), safety and efficacy ...
Gretchen L. Birbeck, Susan T. Herman, Edmund V. Capparelli, Fraction K. Dzinjalamala, Samah G. Abdel Baki, Macpherson Mallewa, Neema M. Toto, Douglas G. Postels, Joseph C. Gardiner, Terrie E. Taylor, Karl B. Seydel   +10 more
doaj   +1 more source