Results 51 to 60 of about 34,408 (289)

Phenobarbital Therapy for Alcohol Withdrawal

, 2021
For the treatment of alcohol withdrawal syndrome (AWS), phenobarbital works differently than benzodiazepines. Benzodiazepines activate only gamma-aminobutyric acid (GABA) whereas phenobarbital has the additional mechanism of inhibiting glutamate ...
Alcenius, Gay, Dressel, R.J., Zastrow, Karen, Muller, Erin, Foster, Mariah   +4 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phenobarbital-Induced Hepatic Dysfunction

, 1976
Phenobarbital has infrequently been reported to cause hepatitis. The previously reported cases of barbiturate-induced jaundice are reviewed and data from two previously unreported cases are presented.
Timothy H. Self, Mark R. Weisburst, William E. Evans   +2 more
core   +1 more source

Serum NMR metabolomics uncovers multiple metabolic changes in phenobarbital-treated dogs [PDF]

, 2021
Introduction Phenobarbital is a commonly used anticonvulsant for the treatment of canine epileptic seizures. In addition to its central nervous system (CNS) depressing effects, long-term phenobarbital administration affects liver function.
Weber, Corinna, Mueller, Elisabeth, Ottka, Claudia, Lohi, Hannes   +3 more
core   +1 more source

Phenobarbital as alternate anticonvulsant for organophosphate‐induced benzodiazepine‐refractory status epilepticus and neuronal injury

Epilepsia Open, 2020
Objective Organophosphates (OPs) such as diisopropylfluorophosphate (DFP) and soman are lethal chemical agents that can produce seizures, refractory status epilepticus (SE), and brain damage.
Doodipala Samba Reddy, Dheepthi Perumal, Victoria Golub, Andy Habib, Ramkumar Kuruba, Xin Wu   +5 more
doaj   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

Molecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy, Jana Löptien, Cornelia Coith, Afroditi Nanou, Katharina Hintelmann, Pinnschmidt Hans, Cordula Petersen, Klaus Pantel, Sabine Riethdorf, Kerstin Borgmann, Harriet Wikman   +10 more
wiley   +1 more source

Phenobarbital as an adjunctive agent for sedation in pediatric intensive care unit patients: A single-center, retrospective study from Colorado

Journal of Pediatric Critical Care
Background: Pediatric patients require pharmacological management of pain and agitation associated with mechanical ventilation. Pain and agitation may be refractory to opioids and alpha-2 agonists, prompting the use of adjunctive analgesics and sedatives
Kelli Jo Welter, Mackenzie N. DeVine, Sharon E. Gordon, Gina Demasellis   +3 more
doaj   +1 more source

THE EFFECT OF GLUTATHIONE DEPLETOR AND INDUCERS IN THE BILIARY EXCRETION OF CADMIUM AND ZINC IN RATS. [PDF]

Basrah Journal of Veterinary Research, 2009
The effect of hepatic glutathione (GSH) depletion and enzymes Induction on hepatic glutathione S-transferase (GST’s) activity, biliary excretion of GSH cadmium, zinc was studied in rats.
Abdel Khailq.A.A, Hanaa.A.Abbas, May.J.Abed   +2 more
doaj   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Interpretation of Controversial Teratogenic Findings of Drugs Such As Phenobarbital [PDF]

, 2011
Objective. To check the debated association between phenobarbital treatment during pregnancy and risk for congenital abnormalities (CAs) in their children. Study Design.
Andrew E. Czeizel, Istvan Dudás, Ferenc Bánhidy   +2 more
core   +1 more source