Results 201 to 210 of about 60,607 (241)
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Toxicology, 1987
Male Sprague-Dawley rats were treated with clofibrate (CLOF) in the diet for 2 years or with 4 i.p. injections of either diethylnitrosamine (DEN) or benzidine (BZ) followed by phenobarbital (PB) in the diet for 67 weeks, or just with PB for 41 weeks. Animals were killed at frequent intervals, some while still on treatment and others after 3 or 6 months
Paul R. Mompon +4 more
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Male Sprague-Dawley rats were treated with clofibrate (CLOF) in the diet for 2 years or with 4 i.p. injections of either diethylnitrosamine (DEN) or benzidine (BZ) followed by phenobarbital (PB) in the diet for 67 weeks, or just with PB for 41 weeks. Animals were killed at frequent intervals, some while still on treatment and others after 3 or 6 months
Paul R. Mompon +4 more
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Mechanism of Phenobarbital Degradation
Journal of Pharmaceutical Sciences, 1962Previous studies on the degradation of barbiturates have indicated that the products of hydrolysis of the ionic and nonionic forms might be different. During the course of a study on the analysis of phenobarbital it was discovered that one of the postulated products (phenylethylacetylurea) could be determined in the presence of phenobarbital ...
Jere E. Goyan +2 more
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ChemInform Abstract: BENZOYLATION OF PHENOBARBITAL
Chemischer Informationsdienst, 1980AbstractDie Benzoylierung von Phenobarbital (5‐Phenyl‐5‐ ethyl‐barbitursäure) (I) wird technisch so durchgeführt, daß (I) mit Benzoylchlorid (II) in Gegenwart von Pyridin auf 120 ‐ 122°C erwärmt wird, wobei man die gewünschte 1‐Benzoyl‐5‐phenyl‐5‐ethyl‐barbitursäure (Benzonal) (III) mit nur 40% Ausbeute erhält.
L. Kh. Vinograd +2 more
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Acetazolamide in Phenobarbital Intoxication
Archives of Internal Medicine, 1966THE BARBITURATES can be divided into two groups on the basis of their metabolism. One group is metabolized primarily by the liver. The short-acting drugs, in general, fit into this group. The second group comprises those barbiturates in which elimination of the active agent is primarily by renal excretion with inactivation by the liver being of less ...
Morton F. Mason +3 more
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Phenobarbital for neonatal jaundice
The Journal of Pediatrics, 1970T H I S C O M M E N T A R Y is prompted by an increasing number of inquiries as to whether it is now indicated to treat hyperbilirubinemia with phenobarbital during the first week of life. In 1968 Catz and Yaffee 1 demonstrated that the conjugation and excretion of bilirubin could be increased significantly in newborn animals by giving sodium barbital ...
David E Fisher, Richard E. Behrman
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Determination of phenobarbital by radioimmunoassay
Journal of Immunological Methods, 1979A radioimmunoassay for phenobarbital has been studied. Antiphenobarbital antisera were obtained by repeated immunization of rabbits with p-succinamidophenobarbital conjugated to bovine serum albumin. Less than 0.2 pmol of phenobarbital could be measured by this procedure.
Takehiko Takatori, Aiko Yamaoka
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Acute Phenobarbital Intoxication
Southern Medical Journal, 1992Phenobarbital is a long-acting barbiturate often prescribed for seizure disorders. It has a high abuse potential and was commonly used in suicide attempts in the past. Although benzodiazepines are now more frequently used in suicide attempts, barbiturate intoxications are still occasionally seen and constitute a medical emergency.
Nancy Lindberg +2 more
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Accumulation of Phenobarbital in Man
Epilepsia, 1963SUMMARYEquations relating serum concentrations of phenobarbital, dose/kg body weight, and rate of elimination were derived. Agreement between calculated and observed concentration‐time curves was obtained in 5 of 6 subjects, and between calculated and observed ratios of level to dose in 18 patients.
Fritz Buchthal, Ole Svensmark
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