Results 211 to 220 of about 36,304 (274)

Modulation of Network Plasticity Opens Novel Therapeutic Possibilities in Cancer, Diabetes, and Neurodegeneration

Advanced Science, EarlyView.
Plasticity changes of molecular networks form a cellular learning process. Signaling network plasticity promotes cancer, metastasis, and drug resistance development. 55 plasticity‐related cancer drug targets are listed (20 having already approved drugs, 9 investigational drugs, and 26 being drug target candidates).
Márk Kerestély, István Narozsny, Levente Szarka, Daniel V. Veres, Peter Csermely, Dávid Keresztes   +5 more
wiley   +1 more source

Antiepileptic Drugs for De Novo Seizure Prevention After Craniotomy: A Systematic Review and Network Meta-Analysis of Current Evidence. [PDF]

J Clin Med
Tsaousi G, Nikolakopoulou A, Tsitsopoulos PP, Pourzitaki C, Mavridis D, Haidich AB.   +5 more
europepmc   +1 more source

PIK3CA Mutations Downregulate PPT1 to Promote Adipogenesis by Suppressing P300 Depalmitoylation and Phase Separation

Advanced Science, EarlyView.
This study demonstrates that somatic PIK3CA mutations suppress PPT1 expression via activation of the PI3K–AKT–c‐JUN axis. This reduction in PPT1 weakens its interaction with P300, thereby increasing palmitoylation at C1176 of P300 and protecting P300 from lysosomal degradation.
Hongrui Chen, Zening Huang, Rui Chang, Wei Gao, Yajing Qiu, Bin Sun, Chen Hua, Xiaoxi Lin   +7 more
wiley   +1 more source

Clinical Deterioration in Dogs with Idiopathic Epilepsy Caused by <i>E. coli</i> Urinary Tract Infection. [PDF]

Animals (Basel)
Reeh S, Schmidt T, Volk HA, Meyerhoff N.
europepmc   +1 more source

Laparoscopic and Endoscopic Cooperative Surgery for Gastric Cancer as an Alternative Treatment in Elderly Patients: A Prospective Observational Study

Annals of Gastroenterological Surgery, EarlyView.
In a prospective study of 20 elderly gastric cancer patients who declined gastrectomy, laparoscopic and endoscopic cooperative surgery (LECS) was technically safe and preserved postoperative function. However, as oncological curability cannot be assured in advanced cases, careful selection and informed consent are essential.
Marie Washio, Keishi Yamashita, Takuya Wada, Mikiko Sakuraya, Hiroki Harada, Tadashi Higuchi, Koshi Kumagai, Yasushi Orihashi, Chika Kusano, Naoki Hiki   +9 more
wiley   +1 more source

High serum unconjugated bilirubin levels following successful treatment of antiepileptic drug-induced bullosa epidermolysis: a case report and review of the literature. [PDF]

Front Med (Lausanne)
Cheng C, Sun Y, Zhang B, Xu H, Xu J, Zhang J.   +5 more
europepmc   +1 more source

Clinical utility of pharyngeal high‐resolution manometry with impedance for upper esophageal sphincter dysfunction in gastroenterology

Advances in Digestive Medicine, EarlyView.
Abstract Pharyngeal high‐resolution manometry with impedance (P‐HRM‐I) is an established assessment method used to evaluate pharyngeal swallowing. It provides precise quantification of swallowing biomechanics that enable the detection of alterations in swallowing physiology.
Mistyka Schar, Taher Omari, Michal Szczesniak, Chien‐Lin Chen, Richard Heddle, Charles Cock   +5 more
wiley   +1 more source

Hospital-Wide Implementation, Clinical Outcomes, and Safety of Phenobarbital for Alcohol Withdrawal.

JAMA Netw Open
Wolpaw BJ, Oren H, Quinnan-Hostein L, Bradley KA, Johnson NJ, Hallgren KA, Gupta A, Kim HN, Granich MA, Steel TL.   +9 more
europepmc   +1 more source

Network analysis of antiseizure medication use, efficacy, and safety in epilepsy: A retrospective cohort study in a tertiary care center. [PDF]

Epilepsy Behav Rep
Morales-Morales MA, García-Gómez E, San-Juan D, Trenado C, Pimentel-Saona DC, Palomares-Salazar Y, Del Río-Quiñones MA, Montalvo-Hérnandez MA, Jesús-Fernández C, Ruiz-Gutierrez JI, Rubinos C.   +10 more
europepmc   +1 more source

Wirelessly Powered Soft Magnetic Robot with Microneedle for Electrical Stimulation and Drug Delivery

Advanced Intelligent Systems, EarlyView.
A wirelessly powered soft magnetic robot integrates microneedles to enable dual functions: electrical stimulation (86.7% efficiency at 6 cm, tunable 0–20 V voltage, 0.4–50 ms pulses) and drug delivery. It switches surfaces via magnetic fields for gastrointestinal tract locomotion and treatment, with in vitro validation in fresh pig gut showing ...
Song Zhao, Liwen Zhang, Shengbin Zhang, Botao Ma, Meng Wang, Yipan Zuo, Xinzhao Zhou, Xueshan Jing, Huawei Chen   +8 more
wiley   +1 more source