Results 201 to 210 of about 3,784 (223)

How to Integrate CYP2D6 Phenoconversion Into Clinical Pharmacogenetics: A Tutorial

Clinical Pharmacology & Therapeutics, 2021
CYP2D6 genotype is increasingly being integrated into practice to guide prescribing of certain medications. The CYP2D6 drug metabolizing enzyme is susceptible to inhibition by concomitant drugs, which can lead to a clinical phenotype that is different from the genotype‐based phenotype, a process referred to as phenoconversion. Phenoconversion is highly
Emily J, Cicali, Amanda L, Elchynski, Kelsey J, Cook, John T, Houder, Cameron D, Thomas, D Max, Smith, Amanda, Elsey, Julie A, Johnson, Larisa H, Cavallari, Kristin, Wiisanen   +9 more
openaire   +2 more sources

Mechanical regulation of myofibroblast phenoconversion and collagen contraction

Experimental Cell Research, 2019
Activated fibroblasts promote physiological wound repair following tissue injury. However, dysregulation of fibroblast activation contributes to the development of fibrosis by enhanced production and contraction of collagen-rich extracellular matrix.
Boris, Hinz, Christopher A, McCulloch, Nuno M, Coelho   +2 more
openaire   +2 more sources

Phenoconversion in pure autonomic failure: a multicentre prospective longitudinal cohort study.

Brain : a journal of neurology
We aimed to describe the clinical features of patients with pure autonomic failure (PAF) preceding phenoconversion that could be useful as predictive markers for advancing α-synuclein-associated neurodegeneration of the brain. Patients diagnosed with PAF
Patricio Millar Vernetti, L. Norcliffe-Kaufmann, J. Palma, Italo Biaggioni, C. Shibao, Amanda Peltier, Roy Freeman, Christopher Gibbons, David S. Goldstein, Phillip A. Low, W. Singer, Elizabeth Coon, M. Miglis, Gregor K Wenning, A. Fanciulli, S. Vernino, R. Betensky, Horacio Kaufmann   +17 more
semanticscholar   +1 more source

I01 Unawareness of motor phenoconversion in huntington disease

Journal of Neurology, Neurosurgery & Psychiatry, 2012
Background Unawareness of disease manifestations in neurodegenerative diseases has been defined by Flashman et al 2002 as “pathological unawareness of a neurological or functional deficit” and by Antoine et al 2004 as “the discrepancy between the patient9s self report and the report of a natural caregiver or the clinical rating of a health ...
E McCusker, D Gunn, E Epping, C Loy, J Long, K Radford, J Griffith, J Mills, J Paulsen   +8 more
openaire   +1 more source

Glymphatic defect in isolated REM sleep behavior disorder is associated with phenoconversion to Parkinson's disease

medRxiv
Isolated rapid eye movement (REM) sleep behavior disorder (iRBD) is characterized by the loss of muscle atonia and abnormal, often violent, movements and vocalizations during REM sleep.
V. Ayral, A. Pastor-Bernier, Véronique Daneault, C. Tremblay, M. Filiatrault, C. Haddad, J. Gagnon, R. Postuma, P. Dušek, S. Mareček, Z. Varga, J. Klein, M. Hu, S. Lehéricy, Isabelle Arnulf, M. Vidailhet, J. Corvol, Iceberg Study Group, S. Rahayel, Quebec Parkinson Network   +19 more
semanticscholar   +1 more source

Phenoconversion in Women and Men With Isolated REM Sleep Behavior Disorder

Neurology
Background and Objectives Isolated REM sleep behavior disorder (iRBD) is strongly associated with synucleinopathies. Previous iRBD cohort studies have primarily focused on older (>50 years), male-predominant cohorts.
Christina Alexandres, S. McCarter, Grace M. Tabatabai, Laurène Leclair-Visonneau, John C. Feemster, T. Gossard, Emma P Strainis, J. Jagielski, Makayla R Kelleher, T. Finstuen, Farwa Ali, Hugo Botha, Jonathan Graff-Radford, Eric J. Olson, D. Sandness, Timothy J Morgenthaler, K. Kantarci, R. Savica, Wolfgang Singer, N. Covassin, Virend K. Somers, James L Kirkland, M. Junna, M. Lipford, Christine A. Matarese, J. L. Moore, M. Tippmann-Peikert, Diego Z. Carvalho, B. Boeve, M. Silber, E. S. St. Louis   +30 more
semanticscholar   +1 more source

EEG Spectro-Spatial Covariance Patterns Related to Phenoconversion in Isolated REM Sleep Behavior Disorder and Their Longitudinal Trajectories in α-Synucleinopathies.

Sleep
STUDY OBJECTIVES This study aimed to identify electroencephalographic (EEG) spectro-spatial covariance patterns associated with phenoconversion in isolated rapid eye movement sleep behavior disorder (iRBD) patients and explore their longitudinal ...
Kyoungeun Park, J. Shin, J. Byun, El Jeong, Han-Joon Kim, K. Jung   +5 more
semanticscholar   +1 more source

Prediction of Phenoconversion into Alpha-Synucleinopathy in Patients with isolated REM Sleep Behavior Disorder Using Event-Related Potentials During Visuospatial Attention Tasks.

Sleep
STUDY OBJECTIVES Isolated REM sleep behavior disorder (iRBD) is recognized as a prodromal stage of alpha-synucleinopathies. Predicting phenoconversion in iRBD patients remains a key challenge.
Kang-Min Choi, Kwang Su Cha, Tae-Gon Noh, Seolah Lee, Y. Shin, J. Byun, J. Jun, J. Shin, Han-Joon Kim, K. Jung   +9 more
semanticscholar   +1 more source

Predicting Phenoconversion in Pure Autonomic Failure (4258)

Neurology, 2020
Elizabeth Coon, Jayawant Mandrekar, Sarah Berini, Eduardo Benarroch, Paola Sandroni, Phillip Low, Wolfgang Singer   +6 more
openaire   +1 more source

The Role of Phenoconversion in the Pharmacogenetics of Psychiatric Medication

Pharmacogenomics, 2023
Martina Hahn, Sibylle C Roll
openaire   +2 more sources