Results 181 to 189 of about 3,015 (189)

The theoretical problems of “prodrome” and “phenoconversion” in neurodegeneration

2023
The recognition of and approach to prodromal symptoms, those which manifest before a diagnosis can be ascertained at the bedside, are of increasing interest in neurodegenerative research. A prodrome is conceived of as an early window into a disease, a critical time when putative disease-modifying interventions may be best suited for examination ...
Andrea, Sturchio, Alberto J, Espay
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How to Integrate CYP2D6 Phenoconversion Into Clinical Pharmacogenetics: A Tutorial

Clinical Pharmacology & Therapeutics, 2021
CYP2D6 genotype is increasingly being integrated into practice to guide prescribing of certain medications. The CYP2D6 drug metabolizing enzyme is susceptible to inhibition by concomitant drugs, which can lead to a clinical phenotype that is different from the genotype‐based phenotype, a process referred to as phenoconversion. Phenoconversion is highly
Emily J, Cicali, Amanda L, Elchynski, Kelsey J, Cook, John T, Houder, Cameron D, Thomas, D Max, Smith, Amanda, Elsey, Julie A, Johnson, Larisa H, Cavallari, Kristin, Wiisanen   +9 more
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Mechanical regulation of myofibroblast phenoconversion and collagen contraction

Experimental Cell Research, 2019
Activated fibroblasts promote physiological wound repair following tissue injury. However, dysregulation of fibroblast activation contributes to the development of fibrosis by enhanced production and contraction of collagen-rich extracellular matrix.
Boris, Hinz, Christopher A, McCulloch, Nuno M, Coelho   +2 more
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I01 Unawareness of motor phenoconversion in huntington disease

Journal of Neurology, Neurosurgery & Psychiatry, 2012
Background Unawareness of disease manifestations in neurodegenerative diseases has been defined by Flashman et al 2002 as “pathological unawareness of a neurological or functional deficit” and by Antoine et al 2004 as “the discrepancy between the patient9s self report and the report of a natural caregiver or the clinical rating of a health ...
E McCusker, D Gunn, E Epping, C Loy, J Long, K Radford, J Griffith, J Mills, J Paulsen   +8 more
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Predicting Phenoconversion in Pure Autonomic Failure (4258)

Neurology, 2020
Elizabeth Coon, Jayawant Mandrekar, Sarah Berini, Eduardo Benarroch, Paola Sandroni, Phillip Low, Wolfgang Singer   +6 more
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The Role of Phenoconversion in the Pharmacogenetics of Psychiatric Medication

Pharmacogenomics, 2023
Martina Hahn, Sibylle C Roll
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PHAROS: Phenoconversion to Manifest Huntington Disease

Archives of Neurology, 2001
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Phenoconversion of Czech idiopathic REM sleep behavior disorder patients

Sleep Medicine, 2017
P. Peřinová, L. Plchová, J. Bušková, D. Kemlink, V. Ibarburu Lorenzo Y Losada, S. Dostálová, T. Vorlová, K. Šonka   +7 more
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Methodological Considerations on CYP2D6 Phenoconversion Due to Drug–Drug Interaction

Clinical Pharmacology & Therapeutics, 2019
Victoria C, Ziesenitz, Gerd, Mikus
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