Results 221 to 230 of about 10,556 (300)

Iloperidone treatment mitigates the Juvenile Huntington's Disease phenotype possibly via Sigma‐1 Receptor Modulation

The FEBS Journal, EarlyView.
We investigated the potential of iloperidone as an activator of Sigma‐1 receptor (S1R) neuroprotective function in juvenile Huntington's disease (jHD). We tested iloperidone on cortical neurons differentiated from patient‐derived iPSCs, demonstrating that it acts as a S1R agonist, decreasing apoptosis, huntingtin aggregation, and oxidative stress ...
Ersilia Fornetti, Gaia Galluzzi, Mario Frezzini, Cécile Exertier, Vittorio Brufani, Gianni Colotti, Giancarlo Ruocco, Jessica Rosati, Angelo Luigi Vescovi, Daniele Narzi, Ilaria Genovese, Andrea Ilari   +11 more
wiley   +1 more source

Targeted, receptor‐mediated delivery of a masked d‐amino acid cell‐penetrating peptide for cell‐specific phototoxicity

The FEBS Journal, EarlyView.
A targeted phototoxic peptide selectively accumulates in cells expressing chemokine‐like receptor 1 (CMKLR1). Phototoxicity of the native peptide is low, but cleavage by lysosomal protease cathepsin B releases a 6‐tetramethylrhodamine (TMR) labeled nona‐ᴅ‐arginine which mediates lysosomal rupture and cell death upon irradiation.
Moritz List, Eva‐Maria Jülke, Annette G. Beck‐Sickinger   +2 more
wiley   +1 more source

Harnessing plant lignin for sustainable materials and chemicals: integrating biosynthesis, structural diversity, and circular bioeconomy perspectives. [PDF]

Front Plant Sci
Jiao H, Al-Tohamy R, Alsharbaty MHM, Sun J, Xiong M, Schagerl M, Ali SS.   +6 more
europepmc   +1 more source

Coniferyl aldehyde from the phenylpropanoid pathway targets pyruvate kinase in Dactylobotrys graminicola to confer sheath rot resistance in hulless barley

Journal of Integrative Plant Biology, EarlyView.
Hulless barley resists the newly identified sheath rot disease caused by the necrotrophic fungal pathogen Dactylobotrys graminicola by releasing coniferyl aldehyde, a natural compound that disrupts energy production in the fungus. ABSTRACT Dactylobotrys graminicola (Dgr), a necrotrophic fungal pathogen, has recently been identified as the causative ...
Haowen Zheng, Liyifan Chen, Jianguo Wei, Yuandi Xu, Rangrang Chen, Yu Li, Yan Liu, Jiahui Yan, Lu Hou, Yiliang Chen, Zhensheng Kang, Haifeng Zhang, Qiang Yao   +12 more
wiley   +1 more source

Effect of margin thickness and cement gap on the fabrication and fit accuracy of additively manufactured crowns in definitive resins with different filler content

Journal of Prosthodontics, EarlyView.
Abstract Purpose To evaluate how commercially available composite resins in varying filler content affect the fabrication and fit accuracy (trueness and precision) of additively manufactured (AM) definitive crowns with different margin thickness and cement gaps by comparing them to subtractively manufactured (SM) polymer‐infiltrated ceramic crowns ...
Mustafa Borga Dönmez, Gülce Çakmak, Çiğdem Kahveci, Amir H. Nejat, Burak Yilmaz, Pinar Altinci   +5 more
wiley   +1 more source

Holdfast adhesion in the kelp Alaria marginata: Cell wall polysaccharides and phenolics

Journal of Phycology, EarlyView.
Abstract Adhesion is a critical process in the survival of seaweeds, especially in wave‐swept environments. Kelp (Laminariales) sporophytes secrete adhesives from specialized rhizoid cells to anchor themselves to the substrate and withstand immense forces applied by waves.
Maisie R. Roy‐Musor, Christa Agoawike, A. Lacey Samuels, Patrick T. Martone   +3 more
wiley   +1 more source

Ultrasonic-assisted extraction, purification, identification, and bioactivity evaluation of phlorotannins from Sargassum fusiforme: A comparative study of RSM and SVM-GA. [PDF]

Ultrason Sonochem
He W, Kong Q, Li H, Wu Y, Huang R, Yu L, Shen S, Xu C, Han Y, Ai Y, Jiang J.   +10 more
europepmc   +1 more source

Polyphenol oxidase depletion in Nicotiana benthamiana enhances recombinant protein purification and preserves native protein integrity

New Phytologist, EarlyView.
Polyphenol oxidases (PPOs) depletion preserves endogenous proteins at their predicted molecular weights and enhances detectable enzymatic activities. (a) Less RbcL crosslinking in ppo mutant of Nicotiana benthamiana. Leaf extracts were incubated for 1 h, separated on protein gels, stained with Coomassie or analyzed by Western blot with the anti‐RbcL ...
Kaijie Zheng, Farnusch Kaschani, Emma C. Watts, Markus Kaiser, Renier A. L. van der Hoorn   +4 more
wiley   +1 more source

Preparation, Structural Characterization, and Synergistic Hypoglycemic Effect of Jujube Polysaccharide-Polyphenol Complex. [PDF]

Foods
Ye Z, Wang W, Li Y, Lu Q, Yang C.
europepmc   +1 more source

Conserved symbiosis‐associated genes in the cycad Encephalartos natalensis suggest co‐option for cyanobacterial symbiosis

New Phytologist, EarlyView.
The heterocyst‐rich Encephalartos natalensis cyanobacterial zone in coralloid root suggests co‐option of conserved symbiosis‐associated genes. This figure was created in BioRender (BioRender.com/https://BioRender.com/n3qveqc). Summary Plant‐cyanobacterial symbioses have evolved independently at least four times across land plants, yet their underlying ...
Cassandra Schoeman, Danielle Roodt, Amy Mc Menamin, Oliver Bezuidt, Choaro Dithugoe, Desré Pinard, Eshchar Mizrachi   +6 more
wiley   +1 more source