Results 41 to 50 of about 5,927,439 (276)

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells

FEBS Letters, EarlyView.
Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López, Özge Yilmaz Ardicli, Mübeccel Akdis   +2 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

The Phenomenon of Darboux Displacements

, 2003
For a class of Schrodinger Hamiltonians the supersymmetry transformations can degenerate to simple coordinate displacements. We examine this phenomenon and show that it distinguishes the Weierstrass potentials including the one-soliton wells and periodic
Abramowitz, Adler, Akhiezer, Andrianov, Arscott, Bagchi, Bagrov, Bateman, Bogdan Mielnik, Boris F. Samsonov, Boya, Cariñena, Cariñena, Cariñena, Cooper, Darboux, David J. Fernández C., de Lange, Drigo-Filho, Dubrobin, Dunne, Fernández, Fernández, Infeld, Junker, Khare, Krasinski, Lax, Matveev, Mielnik, Nieto, Oscar Rosas-Ortiz, Poincaré, Samsonov, Schrödinger, Stahlhofen, Sukumar, Veselov, Witten, Zakhariev   +39 more
core   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

MOBBING PHENOMENON - FACTORS OF DISCRIMINATION AND STRESS [PDF]

Analele Universităţii Constantin Brâncuşi din Târgu Jiu : Seria Economie, 2017
This article focuses on exemplifying the features of discrimination phenomenon in the workplace, a phenomenon that has appeared in the Romanian social studies only in the last 4 years. Mobbing phenomenon has been analyzed by several countries in Europe
ROMANESCU MARCEL LAURENTIU
doaj  

The Significance of the Phenomenon in Immanuel Kant’s and Edmund Husserl’s Transcendental Philosophy [PDF]

Phainomena
The article explores the concept of the phenomenon in the transcendental philosophies of Immanuel Kant and Edmund Husserl, arguing for the intricate connections and divergences between their philosophical frameworks.
Irfan Muhammad
doaj   +1 more source

Mass Phenomenon in Finding Viral Information on Instagram Social Media

Jurnal Sains Sosial dan Humaniora, 2020
The phenomenon of the mass in searching for viral information on social media (Instagram) is a reflection that the internet, especially social media today has become the opiate of the masses in their lives.
Ratu Aulia Bernatta
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The Lost Melody Phenomenon [PDF]

, 2015
A typical phenomenon for machine models of transfinite computations is the existence of so-called lost melodies, i.e. real numbers $x$ such that the characteristic function of the set $\{x\}$ is computable while $x$ itself is not (a real having the first
Carl, Merlin
core