Results 61 to 70 of about 1,607,599 (267)
FEBS Letters, EarlyView.Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara +3 more
wiley +1 more source
α‐Synuclein aggregation landscape from phase separation to neurotoxic intermediates
FEBS Letters, EarlyView.Alpha‐synuclein aggregation in Parkinson's disease involves a complex landscape of transient intermediates, including oligomers, fibrils and liquid–liquid phase separation (LLPS). A view is emerging in which LLPS maturation into solid‐like condensates may contribute to the formation of neurotoxic species.
Silvia Arino +2 more
wiley +1 more source
Małe miasto jako obszar kumulowania potencjału edukacyjnego. Na przykładzie 26-tysięcznego Świecia
Paedagogia Christiana, 2016 Tekst podejmuje problematykę związaną z pejzażem edukacyjno-kulturowym małego miasta. Miasto traktowane jest jako obszar kumulowania doświadczeń społecznych oraz edukacyjnych.
Dagna Dejna +2 more
doaj +1 more source
FEBS Letters, EarlyView.Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley +1 more source
Интеракция. Интервью. Интерпретация, 2023 The book of the famous Russian sociologist L.G. Ionin about Max Weber attracts attention with its unusualness. The review describes various facets of its unusual genre, highlights and examines the levels of the author's consideration of his subject — the
Alexander Nikolaevich Malinkin
doaj +1 more source
On the Phenomenon of Autocomputability
Electronic Notes in Theoretical Computer Science, 2000 Following Trakhtenbrot's concept of autoreducible set, we look at the general phenomenon of autocomputability of infinite binary sequences. We define another appropriate mathematical model of this concept: the strongly autoreducible set. For this purpose, we need to introduce a natural restricted form of wtt-reduction between sets: minimal weak truth ...
openaire +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
THE PHENOMENON OF NATIONAL POLICY IN THE USSR: FORMATION AND DEVELOPMENT PECULIARITIES IN 1917-1930
Гуманитарные и юридические исследования, 2021 The article is devoted to the historical specifics and the formation and development peculiarities of national policy in the RSFSR-USSR after the Bolsheviks came to power in 1917 and the inal formation of its model in the late 1930.
A. Averyanov
doaj
Ценностные тексты в пространстве школы. Как школы Китая развивают стремление к «Китайской мечте»
Научно-педагогическое обозрение, 2023 В современном образовательном поле звучит вопрос о значимости программ воспитания в школьной среде. Одна из задач воспитательной политики – налаживание процесса передачи и усвоения ценностей учениками школ.
Фань Чушу +2 more
doaj +1 more source