Results 61 to 70 of about 6,007,237 (299)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

open access: yesMolecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice   +16 more
wiley   +1 more source

A Review of the Bibliographic Approach to Defining Theory [PDF]

open access: yesبازیابی دانش و نظام‌های معنایی, 2019
Various definitions of theory are presented in the literature of the research method. This variety is visible in the keywords for which the definitions are used.
Farideh Kaab Omeir, Gholamreza Heidari
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

open access: yesMolecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak   +4 more
wiley   +1 more source

Explaining the Reality of the Phenomenon and Phenomenology: Based on Husserl's Philosophy and Its Reconstruction Based on Sadr-ol-Mote'allehin’s Philosophy [PDF]

open access: yesاسلام و مطالعات اجتماعی, 2017
In this essay, first, seven features of the reality behind the phenomenon, are expressed in terms of Husserl's philosophical views. Subsequently, the phenomenological method that Husserl uses according to the features of phenomena in order to recognize ...
Reza Mollaei
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

Lavrentiev Phenomenon in Microstructure Theory [PDF]

open access: yes, 1996
A variational problem arising as a model in martensitic phase transformation including surface energy is studied. It explains the complex, multi-dimensional pattern of twin branching which is often observed in a martensitic phase near the austenite ...
Winter, M
core   +2 more sources

The Hawking-Unruh phenomenon on graphene

open access: yes, 2012
We find that, for a very specific shape of a monolayer graphene sample, a general relativistic-like description of a back-ground spacetime for graphene's conductivity electrons is very natural.
Alfredo Iorio   +26 more
core   +1 more source

An Extension of the Linnik Phenomenon [PDF]

open access: yes, 2012
The Linnik phenomenon concerning the repelling effect of Siegel's zeros is extended to L-functions in a family wider than hitherto considered.Comment: 12 ...
Motohashi, Yoichi
core   +2 more sources

On the Phenomenon of Autocomputability

open access: yesElectronic Notes in Theoretical Computer Science, 2000
Following Trakhtenbrot's concept of autoreducible set, we look at the general phenomenon of autocomputability of infinite binary sequences. We define another appropriate mathematical model of this concept: the strongly autoreducible set. For this purpose, we need to introduce a natural restricted form of wtt-reduction between sets: minimal weak truth ...
openaire   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

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