Results 71 to 80 of about 1,607,599 (267)
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Professional Career: Phenomenon, Concepts, Apocryphas
Вестник Московского университета. Серия 14: ПсихологияBackground. Professional career is an actively evolving socio-psychological phenomenon, which has been studied since the middle of the 20th century as a permanently relevant scientific and scientific-practical issue of high importance for an individual ...
Vladimir A. Tolochek
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THE PHENOMENON OF NEGATIVE EMOTIONS IN THE SOCIAL EXISTENCE OF HUMAN
Antropologìčnì Vimìri Fìlosofsʹkih Doslìdžen', 2018 Purpose. The research is aimed at determining the influence of negative ethical emotions on social life and the activity of the individual, which involves solving the following problems: a) to find out approaches to the typology of ethical emotions, b ...
T. S. Pavlova, V. V. Bobyl
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Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou +12 more
wiley +1 more source
Urban-resolved scales amplifies torrential rainfall in coastal megacities
Scientific ReportsThis study unveils the ability of 200-m near to Large-Eddy Simulation (LES) to resolve smaller scales in urban areas of a coastal megacity Chennai in India, which are crucial for accurately modelling Urban Induced Turbulence (UIT) and Urban Heat Island ...
Konduru Rakesh Teja +2 more
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Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The Phenomenon of Diffusion [PDF]
, 2001 Diffusion is at the core of WG 8.6.2 Employing Rogers’ diffusion theory while in principle addressing other sorts of phenomena is an historic research problem. The applicability of Rogers’ theory is discussed using the perspectives of mechanic and organic organizational settings, reaching the conclusion that Rogers’ diffusion theory has only limited ...
openaire +1 more source