Results 71 to 80 of about 7,414,487 (375)

Gut microbiota diversity is prognostic in metastatic hormone receptor‐positive breast cancer patients receiving chemotherapy and immunotherapy

open access: yesMolecular Oncology, EarlyView.
In this exploratory study, we investigated the relationship between the gut microbiota and outcome in patients with metastatic hormone receptor‐positive breast cancer, treated in a randomized clinical trial with chemotherapy alone or chemotherapy in combination with immune checkpoint blockade.
Andreas Ullern   +7 more
wiley   +1 more source

JUSTICE AS CONTRADICTION

open access: yesДискурс, 2018
The article examines the essence of justice, which is the contradicting unity of equality and inequality. The cause of this contradiction lies in the biosocial nature of man.
V. V. Tuzov
doaj   +1 more source

The Lost Melody Phenomenon [PDF]

open access: yes, 2015
A typical phenomenon for machine models of transfinite computations is the existence of so-called lost melodies, i.e. real numbers $x$ such that the characteristic function of the set $\{x\}$ is computable while $x$ itself is not (a real having the first
Carl, Merlin
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

open access: yesMolecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici   +8 more
wiley   +1 more source

The Concepts of “Appearance” and “Phenomenon” in Transcendental Philosophy (Kant, Husserl, Fink)

open access: yesКантовский сборник, 2020
This study aims, first, to delimit the seemingly synonymous concepts of “phenomenon” and “appearance” and second, to trace the functions of each in Kant’s philosophy and the phenomenological tradition.
Krioukov A. N.
doaj   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

open access: yesMolecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert   +13 more
wiley   +1 more source

Nonequilibrium Goldstone phenomenon in Hybrid Inflation

open access: yes, 2003
We study the onset of Goldstone phenomenon in a hybrid inflation scenario. The physically motivated range of parameters is analyzed in order to meet the cosmological constraints.
Borsanyi, Sz., Patkos, A., Sexty, D.
core   +1 more source

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

open access: yesMolecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande   +11 more
wiley   +1 more source

Screening for lung cancer: A systematic review of overdiagnosis and its implications

open access: yesMolecular Oncology, EarlyView.
Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz   +12 more
wiley   +1 more source

LEGAL PROTECTIONS FOR VICTIMS OF CYBER BLACKMAIL IN THE REPUBLIC OF IRAQ, THE UNITED STATES, AND MALAYSIA

open access: yesMalaysian Journal of Syariah and Law
Cyber blackmail is a crime wherein an individual or corporation threatens to release a victim's private data on social media. As it is a type of crime that expands as technology improves, the rules governing it must be regularly updated and evaluated as
Nazura Abdul Manap, Omar Aljuboori
doaj   +1 more source

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