Results 11 to 20 of about 39,116 (261)

Synthesis of Novel Chalcone-Based Phenothiazine Derivatives as Antioxidant and Anticancer Agents

Molecules, 2020
Based on reported results for the potential medicinal impact of phenothiazine core, as well as the chalcone skeleton that is widely present in many natural products, together with their reported bioactivities, the present work was aimed at combining both
Nourah A. Al Zahrani, Reda M. El-Shishtawy, Mahmoud M. Elaasser, Abdullah M. Asiri   +3 more
doaj   +2 more sources

The Effect of Molecular Conformations and Simulated "Self-Doping" in Phenothiazine Derivatives on Room-Temperature Phosphorescence.

Angewandte Chemie, 2022
The research of purely organic room-temperature phosphorescence (RTP) materials has drawn great attention for their wide potential applications. Besides single-component and host-guest doping systems, the self-doping with same molecule but different ...
Mingxue Gao, Yunfeng Tian, Xiaoning Li, Yanxiang Gong, Manman Fang, Jie Yang, Zhuguo Li   +6 more
semanticscholar   +1 more source

Tuning the Fluorescence and the Intramolecular Charge Transfer of Phenothiazine Dipolar and Quadrupolar Derivatives by Oxygen Functionalization

Journal of the American Chemical Society, 2021
A series of new naphthalimide and phenothiazine-based push–pull systems (NPI-PTZ1–5), in which we structurally modulate the oxidation state of the sulfur atom in the thiazine ring, i.e., S(II), S(IV), and S(VI), was designed and synthesized by the Pd ...
Yogajivan Rout, C. Montanari, Erika Pasciucco, R. Misra, B. Carlotti   +4 more
semanticscholar   +1 more source

Pleiotropic actions of phenothiazine drugs are detrimental to Gram-negative bacterial persister cells

Communications Biology, 2022
Bacterial persister cells are temporarily tolerant to bactericidal antibiotics but are not necessarily dormant and may exhibit physiological activities leading to cell damage. Based on the link between fluoroquinolone-mediated SOS responses and persister
S. G. Mohiuddin, Thao Vy Nguyen, Mehmet A. Orman   +2 more
semanticscholar   +1 more source

Development of High Energy Density Diaminocyclopropenium-Phenothiazine Hybrid Catholytes for Non-Aqueous Redox Flow Batteries.

Angewandte Chemie, 2021
This report describes the development of diaminocyclopropenium-phenothiazine hybrid catholytes for nonaqueous redox flow batteries. The molecules are synthesized in a rapid and modular fashion by appending a diaminocyclopropenium (DAC) substituent to the
Yichao Yan, David B. Vogt, T. Vaid, M. Sigman, M. Sanford   +4 more
semanticscholar   +1 more source

AASLD practice guidance on drug, herbal, and dietary supplement–induced liver injury

, 2022
Hepatology, EarlyView.
Robert J. Fontana, Iris Liou, Adrian Reuben, Ayako Suzuki, M. Isabel Fiel, William Lee, Victor Navarro   +6 more
wiley   +1 more source

Study Of Phenothiazine On p53 Core Domain Mutant Y220C: Finding The Anti-tumor Activity Of Phenothiazine [PDF]

, 2011
The tumor suppressor protein p53 is a transcription factor that plays a key role in the prevention of cancer development. The p53 cancer mutation Y220C induces formation of a cavity on the protein's surface that can accommodate stabilizing small ...
Asif Husain Naqvi, Hardik H. Sheth, Suchindran H S, Vijay Kumar, Vivek Gupta   +4 more
core   +2 more sources

Potential Antioxidant Activity of New Tetracyclic and Pentacyclic Nonlinear Phenothiazine Derivatives

Biochemistry Research International, 2016
The global increase in oxidative stress related diseases such as cancer, cardiovascular, and inflammatory diseases caused by overwhelming level of free radicals in the body has encouraged the search for new antioxidant agents.
Godwill Azeh Engwa, Eugene Lekem Ayuk, Benardeth Ujunwa Igbojekwe, Marcellus Unaegbu   +3 more
doaj   +1 more source

Phenothiazines interfere with dopaminergic neurodegeneration in Caenorhabditis elegans models of Parkinson's disease

Neurobiology of Disease, 2010
Oxidative stress is involved in the pathogenesis of various neurodegenerative disorders, conventional antioxidant strategies have yet been of limited success.
Justyna B. Mocko, Andreas Kern, Bernd Moosmann, Christian Behl, Parvana Hajieva   +4 more
doaj   +1 more source

Orthoptic status before and immediately after heroin detoxification [PDF]

, 2004
Aim: To determine whether changes in orthoptic status take place during withdrawal from heroin and/or methadone. Method: A prospective study of patients, using a repeated measures design, attending a 5 day naltrexone compressed opiate detoxification ...
Beaini, A.Y., Carr, M.P., Firth, A.Y., Pulling, S.   +3 more
core   +2 more sources