Results 51 to 60 of about 39,116 (261)

Short-hairpin RNA library: identification of therapeutic partners for gefitinib-resistant non-small cell lung cancer. [PDF]

, 2014
Somatic mutations of the epidermal growth factor receptor often cause resistance to therapy with tyrosine kinase inhibitor in non-small cell lung cancer (NSCLC). In this study, we aimed to identify partner drugs and pathways that can induce cell death in
Koeffler, H Phillip, Leong, Geraldine, Madan, Vikas, Mori, Seiichi, Sudo, Makoto, Yang, Henry   +5 more
core   +2 more sources

Functional Metal Complexes for Solar–Light‐Driven Energy Conversion

Advanced Materials, EarlyView.
This review provides an exhaustive summary of the recent advancements of functional metal complexes in solar‐to‐electrical, ‐chemical, and ‐thermal energy conversion, comprising material categories, design strategies, underlying principles of operation, and identified improvement of performances.
Yanyan Qin, Dou Luo, Miao Zhang, Wai‐Yeung Wong   +3 more
wiley   +1 more source

Synthesis, spectroscopic characterization, X-ray crystallography, structural activity relationship and antimicrobial activity of some novel 4-(5-(10-(3-N, N-dimethylamino)propyl)-10H-phenothiazine-3-yl)-1, 3, 4-thiadiazole-2-yl) Azo dye/Schiff base derivatives

Future Journal of Pharmaceutical Sciences, 2017
In the present investigation, a series of novel 4 (5-(10-(3-(N,N-dimethylamino)propyl)-10H-phenothiazine-3-yl)-1,3,4-thiadiazo-2-yl) Azo dye/Schiff base derivatives (5a-e & 6a-j) were synthesised by performing diazotization followed by coupling reaction ...
Chandravadivelu Gopi, Vedula Girija Sastry, Magharla Dasaratha Dhanaraju   +2 more
doaj   +1 more source

Phenothiazines Rapidly Induce Laccase Expression and Lignin-Degrading Properties in the White-Rot Fungus Phlebia radiata

Journal of Fungi, 2023
Phlebia radiata is a widespread white-rot basidiomycete fungus with significance in diverse biotechnological applications due to its ability to degrade aromatic compounds, xenobiotics, and lignin using an assortment of oxidative enzymes including laccase.
Matthew P. Hirakawa, Alberto Rodriguez, Mary B. Tran-Gyamfi, Yooli K. Light, Salvador Martinez, Henry Diamond-Pott, Blake A. Simmons, Kenneth L. Sale   +7 more
doaj   +1 more source

Synthesis and Biological Investigation of Phenothiazine-Based Benzhydroxamic Acids as Selective Histone Deacetylase 6 Inhibitors.

Journal of Medicinal Chemistry, 2019
The phenothiazine system was identified as a favorable cap group for potent and selective histone deacetylase 6 (HDAC6) inhibitors. Here, we report the preparation and systematic variation of phenothiazines and their analogues containing a benzhydroxamic
Katharina Vögerl, Nghia Ong, J. Senger, Daniel Herp, Karin Schmidtkunz, M. Marek, Martin Müller, Karin Bartel, T. Shaik, N. J. Porter, D. Robaa, D. Christianson, C. Romier, W. Sippl, M. Jung, F. Bracher   +15 more
semanticscholar   +1 more source

Self‐Assembled Monolayers in p–i–n Perovskite Solar Cells: Molecular Design, Interfacial Engineering, and Machine Learning–Accelerated Material Discovery

Advanced Materials, EarlyView.
This review highlights the role of self‐assembled monolayers (SAMs) in perovskite solar cells, covering molecular engineering, multifunctional interface regulation, machine learning (ML) accelerated discovery, advanced device architectures, and pathways toward scalable fabrication and commercialization for high‐efficiency and stable single‐junction and
Asmat Ullah, Ying Luo, Stefaan De Wolf
wiley   +1 more source

Microfluidically fabricated pH-responsive anionic amphiphilic microgels for drug release [PDF]

, 2015
© 2016 The Royal Society of Chemistry. Amphiphilic microgels of different composition based on the hydrophilic, pH-responsive acrylic acid (AA) and the hydrophobic, non-ionic n-butyl acrylate (BuA) were synthesised using a lab-on-a-chip device ...
Georgiou, T. K., Lu, B., Pamme, N., Tarn, M. D.   +3 more
core   +1 more source

Cohort‐Scale Spatial Autocorrelation for Tumor Prediction in Mid‐Infrared Pathology and Spatial Biomarker Discovery Using MALDI Imaging Lipidomics

Advanced Science, EarlyView.
Computational annotation of various tissue types in heterogeneous samples such as colorectal cancer liver metastasis (CRLM) using spatial autocorrelation analysis on non‐destructive mid‐infrared (MIR) imaging data enabled correlative multimodal mass spectrometry imaging (MSI) for spatial investigation of lipid tumor marker candidates. The method can be
Miriam F. Rittel, Nikolas Ebert, Denis Abu Sammour, Sebastian Graf, Björn C. Fröhlich, Emrullah Birgin, Shad A. Mohammed, Nuh N. Rahbari, Axel Wellmann, Oliver Wasenmüller, Cleo‐Aron Weis, Stefan Schmidt, Carsten Hopf   +12 more
wiley   +1 more source

Halogen Bonding vs. π-Stacked (Charge-Transfer) Interaction of Phenothiazine

Crystals
Phenothiazine is a heteroaromatic molecule capable of various noncovalent interactions, including halogen bonding and π-stacked association. Despite its broad use in functional materials and pharmaceutical ingredients, a systematic comparison of these ...
Sarah Glunt, Md Mahiuddin Sarker, Kiran Avinash, Matthias Zeller, Sergiy V. Rosokha   +4 more
doaj   +1 more source

Kinetics of human butyrylcholinesterase inhibition by 1,9-dimethyl-methylene blue

Journal of the Turkish Chemical Society, Section A: Chemistry, 2021
Alzheimer’s disease (AD) is an irreversible and progressive neurodegenerative disorder, characterized by β-amyloid plaques, neurofibrillary tangles and loss of cholinergic neurons.
Kevser BIBEROGLU
doaj   +1 more source