Results 241 to 250 of about 29,628 (301)

Chorea and Phenothiazines

British Journal of Psychiatry, 1969
The case history is reported here of a woman who has developed involuntary movements while having prolonged phenothiazine therapy. The disorder has developed gradually and is apparently irreversible. It has some unusual features.
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Cytotoxic Potential of Phenothiazines

Current Drug Targets, 2006
Phenothiazines, a kind of sulfur-containing tricyclic compounds, have diverse biological activities including tranquilizer, antibacterial, antitumor and antihelmintic activities due to the relatively lower cytotoxicity. Phenothiazines have been used for clinical treatments as psychotropics.
Kazue Satoh, Masami Kawase, Hiroshi Sakagami, Noboru Motohashi   +3 more
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Cardiovascular effects of phenothiazines

American Heart Journal, 1980
Abstract Phenothiazines have significant electrophysiologic and cardiocirculatory effects. The electrophysiologic effect of these drugs is similar to that reported for quinidine. Phenothiazines decrease the rate of rise of phase 0 of the action potential, decrease the duration and amplitude of phase 2, and prolong phase 3.
William Frishman, William Frishman, Uri Elkayam, Uri Elkayam   +3 more
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Copper‐Catalyzed Domino Reactions for the Synthesis of Phenothiazines

, 2015
A method for the one-pot synthesis of phenothiazines from benzothiazoles and aryl ortho-dihalides was explored. Preliminary work on the mechanism of the reaction suggested that it follows a domino process, including the hydrolysis of benzothiazoles ...
Manna Huang, Dongting Huang, Xinhai Zhu, Y. Wan   +3 more
semanticscholar   +1 more source

Paradoxical effects of phenothiazines

The Psychiatric Quarterly, 1968
Four patients have been described as showing a most unusual paradoxical reaction to phenothiazines at extremely low doses. The theoretical aspects of the problem have been considered.
Herman C. B. Denber, Mary V. Seeman, Frederick Goldner   +2 more
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The Toxicity of Coroxon/Phenothiazine and Coumaphos/Phenothiazine

Research in Veterinary Science, 1962
SUMMARY —Experiments are described which show that anthelmintic doses of mixtures of Coroxon/phenothiazine or Coumaphos/phenothiazine are well tolerated by sheep of all ages and by sheep under various environmental conditions. Metabolism studies with Coroxon/phenothiazine showed that over 90 per cent of an oral dose (6 mg./ kg.) of Coroxon was ...
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Synthesis of phenothiazines from cyclohexanones and 2-aminobenzenethiols under transition-metal-free conditions

, 2013
A convenient method for the synthesis of various substituted phenothiazines from cyclohexanones and 2-aminobenzenethiols using molecular oxygen as hydrogen acceptor in the absence of transition-metals is described.
Yunfeng Liao, Pengcheng Jiang, Shanping Chen, Fuhong Xiao, G. Deng   +4 more
semanticscholar   +1 more source

Synthesis of phenothiazines via ligand-free CuI-catalyzed cascade C-S and C-N coupling of aryl ortho-dihalides and ortho-aminobenzenethiols.

Chemical Communications, 2012
A ligand-free CuI-catalyzed cascade C-S and C-N cross coupling of (hetero)aryl ortho-dihalides and ortho-aminobenzenethiols has been developed, and various phenothiazines were synthesized with excellent regioselectivity.
Chuan Dai, Xiaofei Sun, Xingzhao Tu, Li Wu, Dan Zhan, Qingle Zeng   +5 more
semanticscholar   +1 more source

Infrared Study of Phenothiazine and N-Methyl Phenothiazine

1999
Phenothiazine (PhT) (fig. 1) and N-methyl phenothiazine (N-MePhT) are of special interest for their properties as photosensitizer, possible mutagen, and toxicity. Phenothiazine is employed in the preparation of carbazoles, piperazines [1] and charge-transfer semiconducting complexes [2].
J. L. Núñez, Gloria Tardajos, M. Alcolea Palafox, M. Gil   +3 more
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Mechanism for Phenothiazine Oxidation

Journal of Pharmaceutical Sciences, 1977
The mechanism of phenothiazine degradation was studied by following the degradation of 3,10'-diphenothiazine in ethanol-water mixtures as well as the electrochemical oxidation of phenothiazine. A mechanism, including the formation of an oxidized dimer and some polymers, is suggested.
H. Roseboom, J.H. Perrin
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