Results 41 to 50 of about 6,559 (174)

Photo-oxidative damage to isolated rat liver mitochondria induced by phenothiazines

Revista de Ciências Farmacêuticas Básica e Aplicada, 2005
Photosensitization is a well-known side-effect of phenothiazines that could involve photochemically promoted oxidative damage to mitochondria, leading to the impairment of metabolic functions and apoptosis.
T. Rodrigues, P.A.F. Faria, F.S. Pessoto, C.G. Santos, I.L. Nantes   +4 more
doaj  

10H-1,9-diazaphenothiazine and its 10-derivatives: synthesis, characterisation and biological evaluation as potential anticancer agents

Journal of Enzyme Inhibition and Medicinal Chemistry, 2019
10H-1,9-diazaphenothiazine was obtained in the sulphurisation reaction of diphenylamine with elemental sulphur and transformed into new 10-substituted derivatives, containing alkyl and dialkylaminoalkyl groups at the thiazine nitrogen atom.
Beata Morak-Młodawska, Krystian Pluta, Małgorzata Latocha, Małgorzata Jeleń, Dariusz Kuśmierz, Kinga Suwińska, Aleksander Shkurenko, Zenon Czuba, Magdalena Jurzak   +8 more
doaj   +1 more source

Bifunctional Photocatalysts: Exploiting Proximity for Enhanced Reaction Performance

Chemistry – A European Journal, EarlyView.
This review covers the application of the bifunctional approach to photocatalysis as a means to attain (enhanced) enantioselectivity, and, more in general, as a strategy to enhance the catalytic performance through an effective use of short‐lived reaction intermediates.
Luigi Dolcini, Daniele Lavelli, Alberto Dal Corso, Luca Pignataro   +3 more
wiley   +1 more source

Thiophene-forming one-pot synthesis of three thienyl-bridged oligophenothiazines and their electronic properties

Beilstein Journal of Organic Chemistry, 2016
The pseudo five-component Sonogashira–Glaser cyclization synthesis of symmetrically 2,5-diaryl-substituted thiophenes is excellently suited to access thienyl-bridged oligophenothiazines in a one-pot fashion. Three thienyl-bridged systems were intensively
Dominik Urselmann, Konstantin Deilhof, Bernhard Mayer, Thomas J. J. Müller   +3 more
doaj   +1 more source

Phenothiazines Inhibit SARS-CoV-2 Entry through Targeting Spike Protein

Viruses, 2023
Novel coronavirus disease 2019 (COVID-19), a respiratory disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought an unprecedented public health crisis and continues to threaten humanity due to the persistent emergence ...
Taizhen Liang, Shiqi Xiao, Ziyao Wu, Xi Lv, Sen Liu, Meilin Hu, Guojie Li, Peiwen Li, Xiancai Ma   +8 more
doaj   +1 more source

Recent Advances in Conjugated Microporous Polymers for Photocatalysis: Mechanism, Synthesis and Applications

Exploration, EarlyView.
Conjugated microporous polymers (CMPs) have attracted more and more attention as new photocatalysts due to their unique advantages such as high performance, long stability and strong light absorption. This review summarizes the application of CMPs as a photocatalyst in recent years and introduces the catalytic mechanism.
Dun Zhou, Kongqing Zhang, Xiaobai Li, Yongpeng Liu, Liang Yao, Hongwei Ma   +5 more
wiley   +1 more source

An Insight Into the Potentiation Effect of Potassium Iodide on aPDT Efficacy

Frontiers in Microbiology, 2018
Antimicrobial photodynamic therapy (aPDT) is gaining a special importance as an effective approach against multidrug-resistant strains responsible of fatal infections. The addition of potassium iodide (KI), a non-toxic salt, is recognized to increase the
Cátia Vieira, Ana T. P. C. Gomes, Mariana Q. Mesquita, Nuno M. M. Moura, M. Graça P. M. S. Neves, M. Amparo F. Faustino, Adelaide Almeida   +6 more
doaj   +1 more source

Polymerized Pro‐Estrogen Microneedles via Two Photon Polymerization

Macromolecular Rapid Communications, EarlyView.
Acrylic pro‐drugs of 17β‐estradiol were subjected to spatially controlled two‐photon polymerization to create bespoke microneedle geometries with potential biomedical applications for long‐term transdermal hormone delivery. ABSTRACT Two‐photon polymerization (TPP) is a powerful technique to create microscale structures with high precision, offering ...
Yang Lou, John T. Leman, Harper Serringer, Ke Xia, Christopher N. LaFratta, Chaitanya Ullal, Edmund F. Palermo   +6 more
wiley   +1 more source

Novel Sulfur‐Rich Polymers from Inverse Vulcanization as Functional Building Blocks for Photonics

Macromolecular Rapid Communications, EarlyView.
Isopropenyl aromatic comonomers, in particular novel 2,7‐diisopropenylfluorene and 2,8‐diisopropenyldibenzothiophene, synthesized by sustainable, facile, single‐step SMCCR from available brominated substrates are exploited in the Inverse Vulcanization process to obtain functional Sulfur‐rich macromolecular materials.
Raimondo Insogna, Fabiano Martorelli, Daniela Di Fonzo, Martina Martusciello, Roberto Utzeri, Angelo Angelini, Davide Comoretto, Paola Stagnaro   +7 more
wiley   +1 more source

<b> Photo-oxidative damage to isolated rat liver mitochondria induced by phenothiazines </b>

Revista de Ciências Farmacêuticas Básica e Aplicada, 2009
<p class="MsoNormal" style="margin: 0cm 0cm 0pt; line-height: normal; text-align: justify; mso-layout-grid-align: none;"> Photosensitization is a well-known side-effect of phenothiazines that could involve photochemically promoted oxidative damage ...
T. RODRIGUES, P. A.F. FARIA, F. S. PESSOTO, C. G. SANTOS, I. L. NANTES   +4 more
doaj