Results 41 to 50 of about 36,717 (342)

Synthesis of Diverse Phenothiazines by Direct Thioamination of Arynes with S-(o-Bromoaryl)-S-methylsulfilimines and Subsequent Intramolecular Buchwald–Hartwig Amination

Chemistry Letters, 2018
A facile method for the synthesis of diverse phenothiazines has been achieved by direct thioamination of aryne intermediates with S-(o-bromoaryl)-S-methylsulfilimines and subsequent intramolecular ...
Tsubasa Matsuzawa, Keisuke Uchida, S. Yoshida, T. Hosoya   +3 more
semanticscholar   +1 more source

Analytical Applications of Reactions of Iron(III) and Hexacyanoferrate(III) with 2,10-Disubstituted Phenothiazines

International Journal of Analytical Chemistry, 2009
The presented review is devoted to analytical applications of reactions of Fe(III) and K3[Fe(CN)6] with 2,10-disubstituted phenothiazines (PT). It was found that iron(III) and hexacyanoferrate(III) ions in acidic media easily oxidized PT with the ...
Helena Puzanowska-Tarasiewicz, Joanna Karpińska, Ludmiła Kuźmicka   +2 more
doaj   +1 more source

Towards Asymmetrical Methylene Blue Analogues: Synthesis and Reactivity of 3-N′-Arylaminophenothiazines

Molecules, 2022
The search for new ways to obtain analogues of the well-known Methylene Blue dye is an important synthetic task. Herein, we proposed and developed an approach to the synthesis of 3-N′-arylaminophenothiazines and asymmetrical 3,7-di(N′-arylamino ...
Alena Khadieva, Mansur Rayanov, Ksenia Shibaeva, Alexandr Piskunov, Pavel Padnya, Ivan Stoikov   +5 more
doaj   +1 more source

Antifungal Phenothiazines: Optimization, Characterization of Mechanism, and Modulation of Neuroreceptor Activity.

ACS Infectious Diseases, 2017
New classes of antifungal drugs are an urgent unmet clinical need. One approach to the challenge of developing new antifungal drugs is to optimize the antifungal properties of currently used drugs with favorable pharmacologic properties, so-called drug ...
Marhiah C. Montoya, L. Didone, R. F. Heier, M. Meyers, D. Krysan   +4 more
semanticscholar   +1 more source

Trypanosoma cruzi: effect of phenothiazines on the parasite and its interaction with host cells

Memorias do Instituto Oswaldo Cruz, 1992
Phenothiazines were observed to have a direct effect on Trypanosoma cruzi and on its in vitro interaction with host cells. They caused lysis of trypomastigotes (50 uM/24 h) and,to a lesser extent, epimastigote proliferation.
Solange L. de Castro, Maria Nazaré C. Soeiro, Maria de Nazareth Leal de Meirelles   +2 more
doaj   +1 more source

Photoredox Catalysts Based on N‐(Hexyl)benzothioxanthene‐3,4‐dicarboximide for Photopolymerization and 3D Printing Under Visible Light

Angewandte Chemie, EarlyView.
In this work, two benzothioxanthene imide dyes demonstrate excellent photochemical properties. When used as photocatalysts, they work with amine and iodonium salt or sulfonium salt to form different three‐component systems for effectively initiating photopolymerization under visible light, through photoredox catalysis processes.
Bin Song, Yijun Zhang, Zheng Liu, Pierre Boulay, Céline Dietlin, Fabrice Morlet‐Savary, Michael Schmitt, Didier Gigmes, Jean‐Michel Becht, Frédéric Dumur, Jacques Lalevée   +10 more
wiley   +2 more sources

Pleiotropic actions of phenothiazine drugs are detrimental to Gram-negative bacterial persister cells

Communications Biology, 2022
Phenothiazines, which have previously been approved as antipsychotic drugs, can also reduce growth and metabolism in a range of Gram-negative bacterial pathogens.
Sayed Golam Mohiuddin, Thao Vy Nguyen, Mehmet A. Orman   +2 more
doaj   +1 more source

Amplified Sensitivity in SERS Detection of L1CAM With Silver Plasmonic Mesoporous Silica Capsules on an Imprinted Films

Advanced Materials Interfaces, EarlyView.
This study presents core‐shell Au‐Ag NPs and a novel molecularly imprinted polymer (MIP)‐based material targeting L1CAM. Thionine is used as a monomer to create the MIP on a carbon screen‐printed electrode. Functionalized Au‐AgNCs with Raman reporter 4‐mercaptobenzoic acid and anti‐L1CAM enable selective detection via surface‐enhanced Raman scattering ...
Yuselis Castaño‐Guerrero, Belén Arjones‐Fernández, Felismina T.C. Moreira, Ramon A. Alvarez‐Puebla, Miguel A. Correa‐Duarte, H. Águas, M. Goreti F. Sales   +6 more
wiley   +1 more source

Inhibition of Bacterial RNase P RNA by Phenothiazine Derivatives

Biomolecules, 2016
There is a need to identify novel scaffolds and targets to develop new antibiotics. Methylene blue is a phenothiazine derivative, and it has been shown to possess anti-malarial and anti-trypanosomal activities.
Shiying Wu, Guanzhong Mao, Leif A. Kirsebom   +2 more
doaj   +1 more source

A Double-Edged Sword: Thioxanthenes Act on Both the Mind and the Microbiome

Molecules, 2021
The rising tide of antibacterial drug resistance has given rise to the virtual elimination of numerous erstwhile antibiotics, intensifying the urgent demand for novel agents. A number of drugs have been found to possess potent antimicrobial action during
Marianne Ø. Poulsen, Sujata G. Dastidar, Debalina Sinha Roy, Shauroseni Palchoudhuri, Jette Elisabeth H. Kristiansen, Stephen J. Fey   +5 more
doaj   +1 more source