Results 51 to 60 of about 6,559 (174)

In vitro chloroquine resistance modulation study on fresh isolates of Brazilian Plasmodium falciparum: intrinsic antimalarial activity of phenothiazine drugs

open access: yesMemorias do Instituto Oswaldo Cruz, 2002
Phenothiazine drugs - fluphenazine, chlorpromazine, methotrimeprazine and trifluoperazine - were evaluated as modulating agents against Brazilian chloroquine-resistant fresh isolates of Plasmodium falciparum.
Carla MS Menezes   +6 more
doaj   +1 more source

Polymyxin B combinations with FDA-approved non-antibiotic phenothiazine drugs targeting multi-drug resistance of Gram-negative pathogens

open access: yesComputational and Structural Biotechnology Journal, 2020
The status quo for combating uprising antibacterial resistance is to employ synergistic combinations of antibiotics. Nevertheless, the currently available combination therapies are fast becoming untenable.
Maytham Hussein   +9 more
doaj   +1 more source

Systemic medications associate with surgically treated cataract among adults over 50 years in Finland

open access: yesActa Ophthalmologica, EarlyView.
Abstract Purpose To identify associations between systemic drugs and cataract surgery in Finland. Methods A historic cohort study based on administrative data. Endpoint event was cataract surgery. Use of drugs in question was based on redeemed prescriptions and consisted of 156 drugs.
Antti Riikonen   +3 more
wiley   +1 more source

Sodium butyrate ameliorates renal tubular lipid accumulation through a protein phosphatase 2A/transcription factor EB axis in diabetic nephropathy

open access: yesBritish Journal of Pharmacology, EarlyView.
Abstract Background and Purpose Extensive evidence indicates that lipid accumulation causes renal tubular injury, which further contributes to diabetic nephropathy (DN) progression. Short‐chain fatty acids (SCFAs) play an important role in the maintenance of cellular metabolic health.
Jiayin Tao   +12 more
wiley   +1 more source

Pre‐anaesthetic risk assessment and management of dogs with myxomatous mitral valve disease: a spectrum of care narrative review

open access: yesJournal of Small Animal Practice, EarlyView.
Myxomatous mitral valve disease, an acquired valvular degeneration, is the most common cardiac disorder in dogs, affecting approximately 10% of dogs in primary care veterinary practice. Dogs with myxomatous mitral valve disease frequently require anaesthesia for routine procedures.
I. Levinzon   +3 more
wiley   +1 more source

Antimicrobial Photodynamic Therapy in the Control of COVID-19

open access: yesAntibiotics, 2020
Antimicrobial photodynamic therapy (aPDT), using well known, safe and cost-effective photosensitizers, such as phenothiazines, e.g., methylene blue (MB), or porphyrins, e.g., protoporphyrin-IX (PP-IX), might help to mitigate the COVID-19 either to ...
Adelaide Almeida   +2 more
doaj   +1 more source

Photodynamic inactivation increases cell death rate on persistent Staphylococcus aureus

open access: yesPhotochemistry and Photobiology, EarlyView.
Persistent bacteria have the ability to survive extended periods of antibiotic stress by entering a metabolically dormant state. This study investigated persistence formation in two S. aureus strains and evaluated the effects of PDI using curcumin. Post‐PDI time‐kill assays conducted after metabolic recovery showed a higher rate of bacterial death ...
Maria Vitória Silva Pereira   +3 more
wiley   +1 more source

Role of antimicrobial photodynamic therapy (aPDT) and systemic resveratrol on immediate implant placement in type 2 diabetic rats

open access: yesPhotochemistry and Photobiology, EarlyView.
This study evaluated the combined effects of antimicrobial photodynamic therapy (aPDT) and systemic resveratrol on bone repair around immediately placed implants in type 2 diabetic rats. Resveratrol improved glycemic control and body weight, while aPDT increased implant stability and bone mineralization.
Letícia Pitol‐Palin   +8 more
wiley   +1 more source

Root surface biomodification in periodontal therapy: Biological rationale and clinical applications

open access: yesPeriodontology 2000, EarlyView.
Abstract Regenerative periodontal therapy aims to form new cementum, periodontal ligament, and alveolar bone, all sealed by gingival tissue. The root surface acts as the wound margin during this regeneration process. Root surface biomodification (root conditioning/root decontamination), therefore, seems instrumental in promoting surface decontamination
Muhammad H. A. Saleh   +3 more
wiley   +1 more source

SYNTHESIS AND ELECTRONIC PROPERTIES OF 3-ARYL 10H-PHENOTHIAZINES

open access: yesStudia Universitatis Babes-Bolyai Chemia, 2016
3-Bromo 10H-phenothiazines, even the 10H-unsubstituted derivative, can be efficiently coupled with several boronic acids to give 3-aryl 10H-phenothiazines with good to excellent yields.
Christa S. BARKSCHAT   +1 more
doaj  

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