Results 31 to 40 of about 2,545,958 (345)

Real-Life Performance of Mepolizumab in T2-High Severe Refractory Asthma with the Overlapping Eosinophilic-Allergic Phenotype

open access: yesBiomedicines, 2022
Severe asthma (SA) is categorized into multiple overlapping phenotypes and clinical characteristics driven by complex mechanistic inflammatory pathways. Mepolizumab is a human monoclonal antibody effectively targeting interleukin-5 in severe eosinophilic
Ruperto González-Pérez   +3 more
doaj   +1 more source

Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET

open access: yesNature Network Boston, 2012
Tumor-derived exosomes are emerging mediators of tumorigenesis. We explored the function of melanoma-derived exosomes in the formation of primary tumors and metastases in mice and human subjects.
H. Peinado   +24 more
semanticscholar   +1 more source

The Metabolic Profile of Young, Watered Chickpea Plants Can Be Used as a Biomarker to Predict Seed Number under Terminal Drought

open access: yesPlants, 2023
Chickpea is the second-most-cultivated legume globally, with India and Australia being the two largest producers. In both of these locations, the crop is sown on residual summer soil moisture and left to grow on progressively depleting water content ...
Sarah J. Purdy   +5 more
doaj   +1 more source

Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis

open access: yesBMC Medicine, 2019
Background Plasmodium falciparum infections with slow parasite clearance following artemisinin-based therapies are widespread in the Greater Mekong Subregion.
WWARN K13 Genotype-Phenotype Study Group
doaj   +1 more source

The Tomographic Study and the Phenotype of Wormian Bones

open access: yesDiagnostics, 2023
Background: We describe patients who were recognized via conventional radiographs of the skull as manifesting wormian bones. Wormian bones are not a specific diagnostic entity and can be seen in variable forms of syndromic disorders.
Ali Al Kaissi   +6 more
doaj   +1 more source

Ontological representation, classification and data-driven computing of phenotypes

open access: yesJournal of Biomedical Semantics, 2020
Background The successful determination and analysis of phenotypes plays a key role in the diagnostic process, the evaluation of risk factors and the recruitment of participants for clinical and epidemiological studies.
Alexandr Uciteli   +4 more
doaj   +1 more source

Genetic-Phenotype Analysis of Bifidobacterium bifidum and Its Glycoside Hydrolase Gene Distribution at Different Age Groups

open access: yesFoods, 2023
Human gut microbiota interfere with host development and aging. Bifidobacterium is a microbial genus found in the human digestive tract that has probiotic activities such as improving constipation and enhancing immunity.
Xiaojing Wei   +6 more
doaj   +1 more source

Protection against Pertussis in Humans Correlates to Elevated Serum Antibodies and Memory B Cells

open access: yesFrontiers in Immunology, 2017
Pertussis is a respiratory infection caused by Bordetella pertussis that may be particularly severe and even lethal in the first months of life when infants are still too young to be vaccinated. Adults and adolescents experience mild symptoms and are the
Valentina Marcellini   +30 more
doaj   +1 more source

The psychiatric phenotype of 15q11.2-q13.3 duplications

open access: yesEuropean Psychiatry, 2021
Introduction 15q11.2-q13.3 region is prone to genomic rearrangements leading to both deletions and duplications. A wide spectrum of neuropsychiatric conditions, such as developmental delay/intellectual disability (DD/ID), autism, attention-deficit ...
M. Budisteanu   +11 more
doaj   +1 more source

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