Results 31 to 40 of about 2,438,030 (324)
Melanoma exosomes educate bone marrow progenitor cells toward a pro-metastatic phenotype through MET
Nature Network Boston, 2012 Tumor-derived exosomes are emerging mediators of tumorigenesis. We explored the function of melanoma-derived exosomes in the formation of primary tumors and metastases in mice and human subjects.
H. Peinado +24 more
semanticscholar +1 more source
BMC Medicine, 2019 Background Plasmodium falciparum infections with slow parasite clearance following artemisinin-based therapies are widespread in the Greater Mekong Subregion.
WWARN K13 Genotype-Phenotype Study Group
doaj +1 more source
Ontological representation, classification and data-driven computing of phenotypes
Journal of Biomedical Semantics, 2020 Background The successful determination and analysis of phenotypes plays a key role in the diagnostic process, the evaluation of risk factors and the recruitment of participants for clinical and epidemiological studies.
Alexandr Uciteli +4 more
doaj +1 more source
Phenotype of VCP Mutations in Chinese Amyotrophic Lateral Sclerosis Patients
Frontiers in Neurology, 2022 Mutations in the valosin-containing protein (VCP) gene have been linked to amyotrophic lateral sclerosis (ALS) in the Caucasian populations. However, the phenotype of VCP mutations in Chinese patients with (ALS) remains unclear.
Shu-Yan Feng +9 more
doaj +1 more source
Protection against Pertussis in Humans Correlates to Elevated Serum Antibodies and Memory B Cells
Frontiers in Immunology, 2017 Pertussis is a respiratory infection caused by Bordetella pertussis that may be particularly severe and even lethal in the first months of life when infants are still too young to be vaccinated. Adults and adolescents experience mild symptoms and are the
Valentina Marcellini +30 more
doaj +1 more source
Detection of the Strains Induced in Murine Tibias by Ex Vivo Uniaxial Loading with Different Sensors
Sensors, 2019 In this paper, the characterization of the main techniques and transducers employed to measure local and global strains induced by uniaxial loading of murine tibiae is presented.
Emanuele Rizzuto +7 more
doaj +1 more source
Direction and Constraint in Phenotypic Evolution: Dimension Reduction and Global Proportionality in Phenotype Fluctuation and Responses [PDF]
arXiv, 2021 A macroscopic theory for describing cellular states during steady-growth is presented, which is based on the consistency between cellular growth and molecular replication, as well as the robustness of phenotypes against perturbations. Adaptive changes in high-dimensional phenotypes were shown to be restricted within a low-dimensional slow manifold ...
arxiv
OMIM.org: leveraging knowledge across phenotype–gene relationships
Nucleic Acids Res., 2018 For over 50 years Mendelian Inheritance in Man has chronicled the collective knowledge of the field of medical genetics. It initially cataloged the known X-linked, autosomal recessive and autosomal dominant inherited disorders, but grew to be the primary
J. Amberger +3 more
semanticscholar +1 more source
International Journal of Infectious Diseases, 2023 Objectives: Understanding the immune response in very mild and asymptomatic COVID-19 is crucial for developing effective vaccines and immunotherapies, yet remains poorly characterized.
Ivan Ssali +20 more
doaj
Modeling neurodegeneration in Caenorhabditis elegans
Disease Models & Mechanisms, 2020 The global burden of neurodegenerative diseases underscores the urgent need for innovative strategies to define new drug targets and disease-modifying factors.
Kim A. Caldwell +2 more
doaj +1 more source