Results 21 to 30 of about 1,646,660 (269)

Clinically relevant T cell expansion media activate distinct metabolic programs uncoupled from cellular function

Molecular Therapy: Methods & Clinical Development, 2022
Ex vivo expansion conditions used to generate T cells for immunotherapy are thought to adopt metabolic phenotypes that impede therapeutic efficacy in vivo.
Sarah MacPherson, Sarah Keyes, Marisa K. Kilgour, Julian Smazynski, Vanessa Chan, Jessica Sudderth, Tim Turcotte, Adria Devlieger, Jessie Yu, Kimberly S. Huggler, Jason R. Cantor, Ralph J. DeBerardinis, Christopher Siatskas, Julian J. Lum   +13 more
doaj   +1 more source

The Genome and Phenotypes

, 2023
Understanding processes that generate variation between animals and how this variation is inherited between generations is essential for understanding the importance and challenges of estimating genetic values. This chapter describes the standard quantitative genetic model where phenotype values are generated from genetic, environmental, and other ...
Mrode, Raphael, Pocrnic, Ivan; id_orcid 0000-0001-5246-7428, Gorjanc, Gregor; id_orcid 0000-0001-8008-2787   +2 more
openaire   +1 more source

Case Report: A Case Study on the Neurodevelopmental Profile of a Child With Pallister–Killian Syndrome and His Unaffected Twin

Frontiers in Pediatrics, 2022
Pallister–Killian syndrome is an uncommon genetic disorder that has broad developmental and multisystemic effects. While medical complications are widely reported throughout the literature, research on the neurodevelopmental profile has been limited ...
Carole A. Samango-Sprouse, Carole A. Samango-Sprouse, Carole A. Samango-Sprouse, Mary P. Hamzik, Kenneth Rosenbaum, Kosar Khaksari, Francie Mitchell, Ritika Kommareddi, Michaela R. Brooks, Elizabeth Tipton, Teresa Sadeghin, Andrea L. Gropman, Andrea L. Gropman   +12 more
doaj   +1 more source

Association of mutations in the Plasmodium falciparum Kelch13 gene (Pf3D7_1343700) with parasite clearance rates after artemisinin-based treatments—a WWARN individual patient data meta-analysis

BMC Medicine, 2019
Background Plasmodium falciparum infections with slow parasite clearance following artemisinin-based therapies are widespread in the Greater Mekong Subregion.
WWARN K13 Genotype-Phenotype Study Group
doaj   +1 more source

The Reliability of Histamine Pharmacodynamic Response Phenotype Classification in Children With Allergic Disease

Frontiers in Pharmacology, 2020
We have identified distinct histamine pharmacodynamic response phenotypes in children with allergic disease utilizing histamine iontophoresis with laser Doppler (HILD).
Shaun S. Kumar, Xiaoxi Liu, Catherine M. Sherwin, Catherine M. Sherwin, Bridgette L. Jones, Bridgette L. Jones, Bridgette L. Jones   +6 more
doaj   +1 more source

Electrocardiographic phenotype of exercise-induced arrhythmogenic cardiomyopathy: A retrospective observational study

Frontiers in Cardiovascular Medicine, 2022
IntroductionThe right ventricle can be susceptible to pathologic alterations with exercise. This can cause changes to the ECG. Our aim was to identify the electrocardiographic phenotype of exercise induced (ExI) arrhythmogenic cardiomyopathy (ACM ...
Hielko Miljoen, Hielko Miljoen, Francesco Spera, Katrien Van Kolen, Johan Saenen, Johan Saenen, Guido Claessen, Guido Claessen, Wim Huybrechts, Wim Huybrechts, Andrea Sarkozy, Andrea Sarkozy, Hein Heidbuchel, Hein Heidbuchel   +13 more
doaj   +1 more source

Area from image analyses accurately estimates dry‐weight biomass of juvenile tissue from the moss Ceratodon purpureus

Applications in Plant Sciences, 2021
PREMISE Mosses have long served as models for studying many areas of plant biology. Investigators have used two‐dimensional measurements of juvenile growth from photographs as a surrogate for dry‐weight biomass. The relationship between area and biomass,
Wesley P. Burtscher, Marna A. List, Adam C. Payton, Stuart F. McDaniel, Sarah B. Carey   +4 more
doaj   +1 more source

High Quality Ramie Resource Screening Based on UAV Remote Sensing Phenotype Monitoring

智慧农业, 2022
Ramie is an important fiber crop. Due to the shortage of land resources and the promotion of excellent varieties, the genetic variation and diversity of ramie decreased, which increased the need for investigation and protection of the ramie germplasm ...
FU Hongyu, WANG Wei, LIAO Ao, YUE Yunkai, XU Mingzhi, WANG Ziwei, CHEN Jianfu, SHE Wei, CUI Guoxian   +8 more
doaj   +1 more source

Protection against Pertussis in Humans Correlates to Elevated Serum Antibodies and Memory B Cells

Frontiers in Immunology, 2017
Pertussis is a respiratory infection caused by Bordetella pertussis that may be particularly severe and even lethal in the first months of life when infants are still too young to be vaccinated. Adults and adolescents experience mild symptoms and are the
Valentina Marcellini, Eva Piano Mortari, Giorgio Fedele, Francesco Gesualdo, Elisabetta Pandolfi, Fabio Midulla, Pasqualina Leone, Paola Stefanelli, Alberto Eugenio Tozzi, Rita Carsetti, Rita Carsetti, The Pertussis Study Group, E. Agricola, C. M. Ausiello, G. Buttinelli, I. Campagna, C. Concato, F. Del Chierico, G. Di Mattia, B. Ferretti, A. Frassanito, M. V. Gonfiantini, R. Nenna, A. Nicolai, M. Onori, L. Putignani, C. Rizzo, L. Russo, V. V. Spuri, L. Tanturri, A. Villani   +30 more
doaj   +1 more source

Exploring plant responses to abiotic stress by contrasting spectral signature changes

Frontiers in Plant Science, 2023
In this study, daily changes over a short period and diurnal progression of spectral reflectance at the leaf level were used to identify spring wheat genotypes (Triticum aestivum L.) susceptible to adverse conditions.
Félix Estrada, Félix Estrada, Jaume Flexas, Jose Luis Araus, Freddy Mora-Poblete, Jaime Gonzalez-Talice, Dalma Castillo, Ivan A. Matus, Ana Maria Méndez-Espinoza, Miguel Garriga, Carlos Araya-Riquelme, Cyril Douthe, Benjamin Castillo, Alejandro del Pozo, Gustavo A. Lobos   +14 more
doaj   +1 more source