Results 31 to 40 of about 605,923 (256)

euxhenh/phenotype-cover: First release

, 2022
First release of two phenotype cover (PC) algorithms based on multiset multicover and the cross entropy method.
Euxhen Hasanaj
core   +1 more source

Clinical and Genetic Spectra of Inherited Liver Disease in Children in China

Frontiers in Pediatrics, 2021
Background: Children presenting with chronic liver disease or acute liver failure often have an underlying genetic disorder. The aim of this study was to analyze the clinical and genetic spectra of inherited liver disease in children in a tertiary ...
Youhong Fang, Jindan Yu, Jingan Lou, Kerong Peng, Hong Zhao, Jie Chen   +5 more
doaj   +1 more source

Rac Inhibition Reverses the Phenotype of Fibrotic Fibroblasts [PDF]

, 2009
Background: Fibrosis, the excessive deposition of scar tissue by fibroblasts, is one of the largest groups of diseases for which there is no therapy. Fibroblasts from lesional areas of scleroderma patients possess elevated abilities to contract matrix ...
Christopher P Denton, Abraham, DJ, Denton, CP, Mark Eastwood, Sonali Sonnylal, Shi-Wen, X., Liu Shangxi, Leask, A., Abraham David J., Liu, SX, Shi-wen, X, Denton, C.P., Shangxi Liu, Sonnylal, S, Abraham, D.J., David J Abraham, Liu, S., Andrew Leask, Shi-wen Xu, Denton Christopher P., Eastwood Mark, Eastwood, M, Leask, A, Eastwood, M., Sonnylal Sonali, Leask Andrew, Sonnylal, S.   +26 more
core   +2 more sources

Nitrogen Use Efficiency Phenotype and Associated Genes: Roles of Germination, Flowering, Root/Shoot Length and Biomass

Frontiers in Plant Science, 2021
Crop improvement for Nitrogen Use Efficiency (NUE) requires a well-defined phenotype and genotype, especially for different N-forms. As N-supply enhances growth, we comprehensively evaluated 25 commonly measured phenotypic parameters for N response using
Narendra Sharma, Vimlendu Bhushan Sinha, N. Arun Prem Kumar, Desiraju Subrahmanyam, C. N. Neeraja, Surekha Kuchi, Ashwani Jha, Rajender Parsad, Vetury Sitaramam, Nandula Raghuram   +9 more
doaj   +1 more source

The Genome and Phenotypes

, 2023
Understanding processes that generate variation between animals and how this variation is inherited between generations is essential for understanding the importance and challenges of estimating genetic values. This chapter describes the standard quantitative genetic model where phenotype values are generated from genetic, environmental, and other ...
Mrode, Raphael, Pocrnic, Ivan; id_orcid 0000-0001-5246-7428, Gorjanc, Gregor; id_orcid 0000-0001-8008-2787   +2 more
openaire   +1 more source

A worldwide correlation of lactase persistence phenotype and genotypes [PDF]

, 2010
Background: The ability of adult humans to digest the milk sugar lactose - lactase persistence - is a dominant Mendelian trait that has been a subject of extensive genetic, medical and evolutionary research.
Jones Bryony L, Ingram, C.J.E., Thomas, M.G., Swallow Dallas M, Jones, B.L., Dallas M Swallow, Itan, Y., Yuval Itan, Swallow, D.M., Itan Yuval, Thomas Mark G, Catherine JE Ingram, Ingram Catherine JE, Bryony L Jones, Mark G Thomas   +14 more
core   +1 more source

"Phenotype" and "Clone" [PDF]

Science, 1912
n ...
openaire   +3 more sources

Clinically relevant T cell expansion media activate distinct metabolic programs uncoupled from cellular function

Molecular Therapy: Methods & Clinical Development, 2022
Ex vivo expansion conditions used to generate T cells for immunotherapy are thought to adopt metabolic phenotypes that impede therapeutic efficacy in vivo.
Sarah MacPherson, Sarah Keyes, Marisa K. Kilgour, Julian Smazynski, Vanessa Chan, Jessica Sudderth, Tim Turcotte, Adria Devlieger, Jessie Yu, Kimberly S. Huggler, Jason R. Cantor, Ralph J. DeBerardinis, Christopher Siatskas, Julian J. Lum   +13 more
doaj   +1 more source

Case Report: A Case Study on the Neurodevelopmental Profile of a Child With Pallister–Killian Syndrome and His Unaffected Twin

Frontiers in Pediatrics, 2022
Pallister–Killian syndrome is an uncommon genetic disorder that has broad developmental and multisystemic effects. While medical complications are widely reported throughout the literature, research on the neurodevelopmental profile has been limited ...
Carole A. Samango-Sprouse, Carole A. Samango-Sprouse, Carole A. Samango-Sprouse, Mary P. Hamzik, Kenneth Rosenbaum, Kosar Khaksari, Francie Mitchell, Ritika Kommareddi, Michaela R. Brooks, Elizabeth Tipton, Teresa Sadeghin, Andrea L. Gropman, Andrea L. Gropman   +12 more
doaj   +1 more source

Phenotype-Informed Noncoding Element Scoring

, 2018
<p>Functional characterization of the noncoding genome is essential for the biological understanding of gene regulation and disease. Here, we introduce the computational framework PINES (Phenotype-Informed Noncoding Element Scoring) which predicts ...
Bodea, Corneliu (5515433), Bodea, Corneliu   +1 more
core   +2 more sources