Results 21 to 30 of about 149,168 (238)
Juxtaglomerular Cell Phenotypic Plasticity [PDF]
High Blood Pressure & Cardiovascular Prevention, 2017 Renin is the first and rate-limiting step of the renin-angiotensin system. The exclusive source of renin in the circulation are the juxtaglomerular cells of the kidney, which line the afferent arterioles at the entrance of the glomeruli. Normally, renin production by these cells suffices to maintain homeostasis.
Martini, Alexandre, Danser, Jan
openaire +2 more sources
Nature Communications, 2023 Noradrenergic and mesenchymal identities have been characterized in neuroblastoma cell lines according to their epigenetic landscapes and core regulatory circuitries.
Cécile Thirant +31 more
doaj +1 more source
The Genetic Architecture for Phenotypic Plasticity of the Rice Grain Ionome
Frontiers in Plant Science, 2020 The ionome of the rice grain is crucial for the health of populations that consume rice as a staple food. However, the contribution of phenotypic plasticity to the variation of rice grain ionome and the genetic architecture of phenotypic plasticity are ...
Yongjun Tan +5 more
doaj +1 more source
Mapping the Plasticity of Morphology, Molecular Properties and Function in Mouse Primary Microglia
Frontiers in Cellular Neuroscience, 2022 Microglia exert diverse functions by responding in diverse ways to different stimuli, yet little is known about the plasticity of various phenotypes that microglia display.
Xue Jiang +10 more
doaj +1 more source
Loss of SNAI1 induces cellular plasticity in invasive triple-negative breast cancer cells
Cell Death and Disease, 2022 The transcription factor SNAI1 mediates epithelial-mesenchymal transition, fibroblast activation and controls inter-tissue migration. High SNAI1 expression characterizes metastatic triple-negative breast carcinomas, and its knockout by CRISPR/Cas9 ...
Chrysoula Tsirigoti +4 more
doaj +1 more source
Biomedicines, 2021 In non-small cell lung cancer (NSCLC), stroma-resident and tumour-infiltrating macrophages may facilitate an immunosuppressive tumour microenvironment (TME) and hamper immunotherapeutic responses. Analysis of tumour-associated macrophage (TAM) plasticity
Lauren Evans +5 more
doaj +1 more source
Role of dual specificity phosphatases (DUSPs) in melanoma cellular plasticity and drug resistance
Scientific Reports, 2022 Melanoma cells exhibit phenotypic plasticity that allows transition from a proliferative and differentiated phenotype to a more invasive and undifferentiated or transdifferentiated phenotype often associated with drug resistance.
Mithalesh K. Singh +4 more
doaj +1 more source
Ecology and Evolution, 2021 Populations adapt to novel environmental conditions by genetic changes or phenotypic plasticity. Plastic responses are generally faster and can buffer fitness losses under variable conditions.
Daniel Romero‐Mujalli +6 more
doaj +1 more source
Phenotypic plasticity can facilitate adaptive evolution in gene regulatory circuits
BMC Evolutionary Biology, 2011 Background Many important evolutionary adaptations originate in the modification of gene regulatory circuits to produce new gene activity phenotypes. How do evolving populations sift through an astronomical number of circuits to find circuits with new ...
Martin Olivier C +2 more
doaj +1 more source