Results 41 to 50 of about 294,085 (294)

Role of dual specificity phosphatases (DUSPs) in melanoma cellular plasticity and drug resistance

Scientific Reports, 2022
Melanoma cells exhibit phenotypic plasticity that allows transition from a proliferative and differentiated phenotype to a more invasive and undifferentiated or transdifferentiated phenotype often associated with drug resistance.
Mithalesh K. Singh, Sarah Altameemi, Marcos Lares, Michael A. Newton, Vijayasaradhi Setaluri   +4 more
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Macrophage Plasticity and Function in the Lung Tumour Microenvironment Revealed in 3D Heterotypic Spheroid and Explant Models

Biomedicines, 2021
In non-small cell lung cancer (NSCLC), stroma-resident and tumour-infiltrating macrophages may facilitate an immunosuppressive tumour microenvironment (TME) and hamper immunotherapeutic responses. Analysis of tumour-associated macrophage (TAM) plasticity
Lauren Evans, Kate Milward, Richard Attanoos, Aled Clayton, Rachel Errington, Zsuzsanna Tabi   +5 more
doaj   +1 more source

The phenotypic equilibrium of cancer cells: From average-level stability to path-wise convergence

, 2015
The phenotypic equilibrium, i.e. heterogeneous population of cancer cells tending to a fixed equilibrium of phenotypic proportions, has received much attention in cancer biology very recently.
Niu, Yuanling, Wang, Yue, Zhou, Da
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Born to learn: The inspiration, progress, and future of evolved plastic artificial neural networks [PDF]

, 2018
Biological plastic neural networks are systems of extraordinary computational capabilities shaped by evolution, development, and lifetime learning. The interplay of these elements leads to the emergence of adaptive behavior and intelligence.
Abbott, Abraham, Abraham, Alexander, Allis, Alpaydin, Anderson, Andrea Soltoggio, Angeline, Arifovic, Arnold, Arnold, Ay, Bailey, Baldwin, Baxter, Baxter, Bear, Beer, Bengio, Bengio, Bentley, Best, Bienenstock, Birmingham, Blynel, Boers, Bourlard, Brown, Bullinaria, Bullinaria, Bullinaria, Bullinaria, Bullinaria, Bullinaria, Bullinaria, Butz, Butz, Bäck, Cabessa, Carew, Carlson, Carver, Cervier, Chklovskii, Clark, Cliff, Clutton-Brock, Coleman, Cooper, Damasio, Darwin, Dawkins, Deary, Deng, de Vladar, Di Paolo, Di Paolo, Dobzhansky, Doidge, Downing, Downing, Doya, Doya, Draganski, Dudai, Durr, Edelman, Eiben, Ellefsen, Ellefsen, Eskridge, Fellous, Fernando, Fernando, Finnie, Floreano, Floreano, Floreano, Floreano, Floreano, Floreano, Fogel, Fontanari, Friston, Fujii, Funahashi, Gerstner, Gerstner, Goldberg, Goodfellow, Graves, Greve, Grossberg, Gruau, Gu, Gustafsson, Hansen, Happel, Harrington, Harris-Warrick, Harvey, Hasselmo, Hasselmo, Hasselmo, Hawkins, Hebb, Hensch, Hinton, Hinton, Hinton, Hochreiter, Hoinville, Holland, Holland, Hopkins, Hornby, Howard, Howard, Howard, Hull, Husbands, Izhikevich, Izhikevich, Jaeger, Jo, Kaas, Kandel, Kandel, Katz, Katz, Katz, Kenneth O. Stanley, Khan, Khan, Khan, Khan, Kirkpatrick, Kiyota, Klug, Kohonen, Kohonen, Kolb, Kolb, Kondo, Koutník, Koza, Krichmar, Krizhevsky, Kumaran, Kupfermann, Køppe, Lake, Lalejini, Lamprecht, Langton, Lanzi, LeCun, LeDoux, Lee, Lehman, Lehman, Lehman, Levy, Lüders, Lüders, Maass, Maniadakis, Marder, Marder, Markram, Mattiussi, Mayley, McClelland, McQuesten, Meng, Merzenich, Michalewicz, Michalski, Miconi, Miller, Miller, Millington, Monroe, Mouret, Murre, Niv, Nogueira, Nogueira, Nolfi, Nolfi, Nolfi, Nolfi, Norouzzadeh, Offerman, Oja, Oquab, Orchard, Ormrod, Pan, Pascual-Leone, Pavlov, Pehlevan, Pigliucci, Rauschecker, Rawal, Rescorla, Risi, Risi, Risi, Risi, Risi, Roberts, Robins, Roff, Rolls, Rumelhart, Russell, Russo, Sanchez, Schmidhuber, Schmidhuber, Schmidhuber, Schmidhuber, Schreiweis, Schroll, Schultz, Schultz, Schultz, Sebastian Risi, Silva, Silva, Silver, Sims, Sims, Sipper, Skinner, Skinner, Smith, Smith, Smith, Soltoggio, Soltoggio, Soltoggio, Soltoggio, Soltoggio, Soltoggio, Soltoggio, Soltoggio, Sporns, Staddon, Stanley, Stanley, Stanley, Stanley, Stanley, Steels, Stone, Suri, Suri, Sutton, Taylor, Tessier-Lavigne, Thorndike, Thrun, Thrun, Thrun, Tonelli, Tonelli, Urzelai, Varela, Venkatesh, Vitay, Wagner, Walters, Widrow, Willshaw, Yamauchi, Yao, Yao, Yoder, Young, Ziemke   +282 more
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Phenotypic plasticity can facilitate adaptive evolution in gene regulatory circuits

BMC Evolutionary Biology, 2011
Background Many important evolutionary adaptations originate in the modification of gene regulatory circuits to produce new gene activity phenotypes. How do evolving populations sift through an astronomical number of circuits to find circuits with new ...
Martin Olivier C, Espinosa-Soto Carlos, Wagner Andreas   +2 more
doaj   +1 more source

Adaptive and nonadaptive plasticity in changing environments: Implications for sexual species with different life history strategies

Ecology and Evolution, 2021
Populations adapt to novel environmental conditions by genetic changes or phenotypic plasticity. Plastic responses are generally faster and can buffer fitness losses under variable conditions.
Daniel Romero‐Mujalli, Markus Rochow, Sandra Kahl, Sofia Paraskevopoulou, Remco Folkertsma, Florian Jeltsch, Ralph Tiedemann   +6 more
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Galectin-12 in Cellular Differentiation, Apoptosis and Polarization. [PDF]

, 2018
Galectin-12 is a member of a family of mammalian lectins characterized by their affinity for β-galactosides and consensus amino acid sequences. The protein structure consists of a single polypeptide chain containing two carbohydrate-recognition domains ...
Liu, Fu-Tong, Wan, Lei, Yang, Ri-Yao
core   +2 more sources

Eco-evolutionary dynamics in fragmented landscapes [PDF]

, 2017
Peer ...
Altermatt, Astegiano, Baguette, Baguette, Baguette, Becks, Bell, Bell, Bestion, Bestion, Bitume, Blanquart, Bocedi, Bocedi, Bonduriansky, Bonte, Burgess, Carazo, Cheptou, Cheviron, Clobert, Clobert, Clobert, Cook, Cote, Crespi, Cushman, Darwin, De Meester, Delgado, DiBattista, DiBattista, Dixo, Dobzhansky, Duputié, Edelaar, Edelaar, Ellner, Evans, Fahrig, Farkas, Farkas, Farkas, Fontúrbel, Frank, Fronhofer, Fronhofer, Fukami, Fussmann, Galtier, Gandon, Gandon, Garant, Garel, Ghalambor, Gomulkiewicz, Gomulkiewicz, Guillaume, Guillaume, Gyllenberg, Haddad, Haddad, Hand, Hanski, Hanski, Hanski, Hanski, Hanski, Hanski, Hanski, Hanski, Hartl, Hassell, Hendry, Hendry, Hendry, Hendry, Henry, Higgins, Holt, Holt, Holt, Hughes, Jacob, Kawecki, Keymer, Kinnison, Kronholm, Kubisch, Laughlin, Lechowicz, Legrand, Legrand, Legrand, Leibold, Leimu, Lenormand, Lewontin, Li, Li, Lohr, Lohr, Lopez, Low-Décarie, Lynch, Manel, Massot, Meester, Morris, Mouquet, Nadeau, Nee, North, Nosil, Orsini, Orsini, Pearse, Pelletier, Perrin, Phillips, Poethke, Poethke, Poethke, Post, Ravigné, Ravigné, Riba, Richardson, Ritchie, Robert, Robinson, Rodrigues, Roissart, Ronce, Ronce, Ronce, Rousset, Räsänen, Saastamoinen, Scheiner, Schoener, Schtickzelle, Schtickzelle, Shefferson, Shine, Stapley, Tack, Taylor, Taylor, Travis, Travis, Trochet, Turner, Urban, Urban, Vellend, Walser, Wheat, Wiegand, Wiens, Wilcove, Yeaman, Yoshida, Zheng   +163 more
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Evolution of phenotypic fluctuation under host-parasite interactions.

PLoS Computational Biology, 2021
Robustness and plasticity are essential features that allow biological systems to cope with complex and variable environments. In a constant environment, robustness, i.e., insensitivity of phenotypes, is expected to increase, whereas plasticity, i.e ...
Naoto Nishiura, Kunihiko Kaneko
doaj   +1 more source

Testing for Phenotypic Plasticity

Philosophy, Theory, and Practice in Biology, 2021
Phenotypic plasticity, or an organism’s capacity to change its phenotype in response to environmental variation, is a pervasive—perhaps even ubiquitous—feature of the biological world.
Aja Watkins
doaj   +1 more source