Results 1 to 10 of about 134,687 (118)

Shaping Plant Adaptation in a Warmer World: Developmental Plasticity Under Moderately Elevated Temperatures. [PDF]

Plants (Basel)
As global warming raises ambient temperatures, plant growth and productivity are being profoundly affected. Although the impacts of extreme heat stress have received extensive attention, the developmental consequences of moderately elevated temperatures ...
Zhai J, Liu X, Sun X, Han R, Zhang J, Liang Y.   +5 more
europepmc   +2 more sources

Functional divergence of conserved developmental plasticity genes between two distantly related nematodes. [PDF]

Sci Rep
Genes diverge in form and function in multiple ways over time; they can be conserved, acquire new roles, or eventually be lost. However, the way genes diverge at the functional level is little understood, particularly in plastic systems.
Wighard S, Witte H, Sommer RJ.
europepmc   +2 more sources

Decoding the activated stem cell phenotype of the neonatally maturing pituitary

eLife, 2022
The pituitary represents the endocrine master regulator. In mouse, the gland undergoes active maturation immediately after birth. Here, we in detail portrayed the stem cell compartment of neonatal pituitary.
Emma Laporte, Florian Hermans, Silke De Vriendt, Annelies Vennekens, Diether Lambrechts, Charlotte Nys, Benoit Cox, Hugo Vankelecom   +7 more
doaj   +1 more source

Developmental Disruption of Erbb4 in Pet1+ Neurons Impairs Serotonergic Sub-System Connectivity and Memory Formation

Frontiers in Cell and Developmental Biology, 2021
The serotonergic system of mammals innervates virtually all the central nervous system and regulates a broad spectrum of behavioral and physiological functions.
Candela Barettino, Álvaro Ballesteros-Gonzalez, Andrés Aylón, Xavier Soler-Sanchis, Leticia Ortí, Selene Díaz, Isabel Reillo, Francisco García-García, Francisco José Iborra, Cary Lai, Nathalie Dehorter, Xavier Leinekugel, Nuria Flames, Isabel Del Pino   +13 more
doaj   +1 more source

A Robust Mammary Organoid System to Model Lactation and Involution-like Processes

Bio-Protocol, 2021
The mammary gland is a highly dynamic tissue that changes throughout reproductive life, including growth during puberty and repetitive cycles of pregnancy and involution. Mammary gland tumors represent the most common cancer diagnosed in women worldwide.
Elsa Charifou, Jakub Sumbal, Zuzana Koledova, Han Li, Aurelie Chiche   +4 more
doaj   +1 more source

Protocol for establishing organoids from human ovarian cancer biopsies

STAR Protocols, 2021
Summary: Ovarian cancer (OC) is the most lethal gynecological cancer. Faithful research models are indispensable to the progression of understanding OC etiology and therapy.
Nina Maenhoudt, Hugo Vankelecom
doaj   +1 more source

Primary Mammary Organoid Model of Lactation and Involution

Frontiers in Cell and Developmental Biology, 2020
Mammary gland development occurs mainly after birth and is composed of three successive stages: puberty, pregnancy and lactation, and involution. These developmental stages are associated with major tissue remodeling, including extensive changes in ...
Jakub Sumbal, Jakub Sumbal, Aurelie Chiche, Elsa Charifou, Zuzana Koledova, Han Li   +5 more
doaj   +1 more source

Fluorescence Imaging of 3D Cell Models with Subcellular Resolution

Bio-Protocol, 2022
Over the past years, research has made impressive breakthroughs towards the development and implementation of 3D cell models for a wide range of applications, such as drug development and testing, organogenesis, cancer biology, and personalized medicine.
Indra Van Zundert, Nina Maenhoudt, Silke De Vriendt, Hugo Vankelecom, Beatrice Fortuni, Susana Rocha   +5 more
doaj   +1 more source

Distinct Mechanisms Underlie Developmental Plasticity and Adult Acclimation of Thermogenic Capacity in High-Altitude Deer Mice

Frontiers in Physiology, 2021
Developmental plasticity can elicit phenotypic adjustments that help organisms cope with environmental change, but the relationship between developmental plasticity and plasticity in adult life (e.g., acclimation) remains unresolved. We sought to examine
Catherine M. Ivy, Haley Prest, Claire M. West, Graham R. Scott   +3 more
doaj   +1 more source

Protocol for quantitative evaluation of the impact of paracrine senescence on cellular reprogramming in cultured cells and mouse models

STAR Protocols, 2023
Summary: We present a protocol to evaluate the impact of senescence secretome on reprogramming to pluripotency using both cellular and mouse models. First, we describe the in vitro reprogramming procedure using conditioned medium derived from senescent ...
Jérémy Chantrel, Cheng Chen, Jun Zhang, Han Li   +3 more
doaj   +1 more source