Results 111 to 120 of about 340,700 (262)

Increased yolk lipid mobilization promotes zebrafish post-segmentation growth via an Hnf4-lipoprotein axis

Cell Reports
Summary: Embryogenesis demands an increasing nutrient supply, yet how maternal reserves are temporally delivered remains unclear. In egg-laying vertebrates, reserves are pre-deposited in the yolk, providing a closed system to dissect this problem.
Tong Sun, Yizhu Tao, Yingjie Zeng, Ran Ai, Tong Li, Xinyu Li, Xueshan Li, Ruiping He, Zhikun Jia, Xiaohan Sun, Zhuanghui Feng, Xiangyi Liu, Xingyu Kong, Linzhang Huang, Lei Chen, Jinfei Ni, Li Chen, Wei Dai   +17 more
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

The recent advances of phenotypes in acute exacerbations of COPD

, 2017
Aiyuan Zhou,1–3 Zijing Zhou,1–3 Yiyang Zhao,1–3 Ping Chen1–3 1Department of Respiratory Medicine, The Second Xiangya Hospital, 2Research Unit of Respiratory Disease, 3Diagnosis and Treatment Center of Respiratory Disease, Central
Chen P, Zhou A, Zhao Y, Zhou Z
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Development and validation of an integrative 54 biomarker-based risk identification model for multi-cancer in 42,666 individuals: a population-based prospective study to guide advanced screening strategies

Biomarker Research
Background Early identification of high-risk individuals is crucial for optimizing cancer screening, particularly when considering expensive and invasive methods such as multi-omics technologies and endoscopic procedures.
Renjia Zhao, Huangbo Yuan, Yanfeng Jiang, Zhenqiu Liu, Ruilin Chen, Shuo Wang, Linyao Lu, Ziyu Yuan, Zhixi Su, Qiye He, Kelin Xu, Tiejun Zhang, Li Jin, Ming Lu, Weimin Ye, Rui Liu, Chen Suo, Xingdong Chen   +17 more
doaj   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

Molecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera, Laura Vela‐Martín, Pablo Fernández‐Navarro, José Luis López‐Lorenzo, Javier Cornago, Pilar Llamas, Eduardo Pérez‐Gómez, José Luis Marín‐Rubio, Manuel Fresno, Javier Santos, José Fernández‐Piqueras, María Villa‐Morales   +11 more
wiley   +1 more source

Faculty of Agriculture, Belgrade

, 2014
: Results of the effect of direct and indirect selection on quantitative properties of milk production of first calving Simmental cows in Serbia, are presented in the paper.
Phenotypes In, Simmental Cows
core  

H2S induces apoptosis of tumors with high IDO1 expression via NR4A1-BCL-2 and SOCS3 pathways

Cellular & Molecular Biology Letters
Background Hydrogen sulfide (H2S) has been reported to exert both protumor and antitumor functions. It is worthy to clarify the condition under which H2S exerts antitumor effects and its underlying mechanism.
Zhen Ning Tony He, Fangzhou Meng, Xiaoyang Qian, Yuying Liu, Xin Fang, Dan Yang, Qing Yang   +6 more
doaj   +1 more source

A compact five-gene immuno-fibrotic profile distinguishing systemic sclerosis subtypes with PXDN validated as a fibrosis-associated target

Frontiers in Immunology
IntroductionSystemic sclerosis (SSc) is a heterogeneous autoimmune disease characterized by a paucity of reliable biomarkers for accurate diagnosis and subtype stratification.
Xiangyue Zhao, Xiangyue Zhao, Xiangyue Zhao, Kejian Hu, Yinzhi Cui, Wen Li, Zhiyao Li, Pu Feng, Wenping Xie, Wenping Xie, Xingcheng Xiang, Wen Xu, Junzhang Chen, Pingcuo Wangzha, Xiao Long, Jiucun Wang, Jiucun Wang, Jiucun Wang, Haiyan Chu   +18 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source