Results 101 to 110 of about 340,700 (262)

LorDist: a novel method for calculating the distance based on functional data analysis with application to longitudinal microbial data

Microbiology Spectrum
Longitudinal human microbial data offer insights into microbiome dynamics over time. Traditional methods usually overlook temporal relationships among samples from the same subject.
Xinhe Qi, Menghan Zhang, Tongqing Wei, Jinran Lin, Xingming Zhao, Yin Yao, Yueqing Hu, Yan Zheng   +7 more
doaj   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Dynamic single-cell transcriptomics reveals lsamp-guided neural network formation in male S. japonicum driving female reproduction

Nature Communications
Sexual maturation and egg production in schistosomes require sustained male-female pairing, yet the cellular dynamics underlying this process remain poorly understood.
Yanmin You, Shaoyun Cheng, Xu Chen, Xi Chen, Cun Yi, Mingqi Cai, Fang Luo, Xiaoling Wang, Yuxiang Xie, Wenbin Yang, Lei Xiu, Mengjie Gu, Chengsong Sun, Lele Huo, Gongwen Chen, Shan Li, Jipeng Wang, Wei Hu   +17 more
doaj   +1 more source

Lysyl oxidase (LOX)‐mediated remodeling of the extracellular matrix

FEBS Letters, EarlyView.
The lysyl oxidase (LOX) family of enzymes drives extracellular matrix remodeling by oxidizing collagen, elastin, and fibronectin, promoting covalent cross‐link formation. This activity regulates tissue architecture and mechanical properties, while its dysregulation contributes to fibrosis, cardiovascular disease, glaucoma, connective tissue disorders ...
Fernando Rodríguez‐Pascual, Marta Navarro‐Gutiérrez, Verónica Romero‐Albillo, Raquel Jiménez‐Sánchez   +3 more
wiley   +1 more source

H3K4me1 directs H3K36me2 and H3K36me3 deposition in land plants

Nature Communications
Monomethylation of histone 3 lysine 4 (H3K4me1) marks enhancers in mammals. However, the function of H3K4me1 in plants remains largely unclear. Here, we present the genome-wide distribution of H3K4me1 in diverse species across evolution, revealing a ...
Jiabing Wu, Jiachen Wang, Kangxi Du, Yingping Li, Wenhao Xie, Chenxi He, Qidan Xing, Xiang Li, Xiaoyu Zhu, Zhen Wu, Xiaolong Wu, Linghao Zhang, Wen-Hui Shen, Fei Lan, Jianhua Gan, Bing Liu, Aiwu Dong   +16 more
doaj   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Cryo-ET and MD simulations reveal that dynein-2 is tuned for binding to the A-tubule of the ciliary doublet

The EMBO Journal
Eukaryotic cilia and flagella are thin structures present on the surface of cells, playing vital roles in signaling and cellular motion. Cilia assembly depends on intraflagellar transport (IFT) along doublet microtubules (doublets).
Haoqiang K He, Shintaroh Kubo, Xuwei Chen, Qianru H Lv, Azusa Kage, Muneyoshi Ichikawa   +5 more
doaj   +1 more source

The Role of Homocysteine in Pediatric MASLD: A Bipotential Biomarker of Cardiovascular Risk and Liver Fibrosis

Life
The increasing prevalence of metabolic dysfunction-associated fatty liver disease (MASLD) in children requires robust, non-invasive biomarkers to enable accurate disease staging and risk stratification.
Antonella Mosca, Nadia Panera, Giulia Andolina, Luca Della Volpe, Anna Pastore, Maria Rita Braghini, Lidia Monti, Paola Francalanci, Giovanna Soglia, Andrea Pietrobattista, Anna Alisi   +10 more
doaj   +1 more source

Digital Phenotyping

, 2022
This thesis is centered around the development and application of a digital platform for passive behavioral human subject research.This platform named Behapp (https://behapp.com), developed at the University of Groningen, makes use of mobile ‘apps’ to passively record various attributes related to social and explorative behavior through the smartphones
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source