Results 81 to 90 of about 340,700 (262)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Phenotypes

, 2015
Tree ID (Site, Family, Tree), height, diameter, volume, velocity, Resistograph, Xray (wood density), MoE (modulus of ...
Ilga Porth (138357), Charles Chen (121346), Yousry A. El-Kassaby (203286), Gamal El-Dien, Omnia, Jaroslav Klápste (3245457), Porth, Ilga, Omnia Gamal El-Dien (3245454), El-Kassaby, Yousry A., Chen, Charles, Klápste, Jaroslav, El-Kassaby, Yousry, A., El-Kassaby, Yousry, A. (3245463), Blaise Ratcliffe (3245460), Ratcliffe, Blaise   +13 more
core   +1 more source

Nanobodies: From Discovery to AI-Driven Design

Biology
Nanobodies, derived from naturally occurring heavy-chain antibodies in camelids (VHHs) and sharks (VNARs), are unique single-domain antibodies that have garnered significant attention in therapeutic, diagnostic, and biotechnological applications due to ...
Haoran Zhu, Yu Ding
doaj   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Mortality in COPD patients according to clinical phenotypes

, 2018
Rafael Golpe, María Suárez-Valor, Irene Martín-Robles, Pilar Sanjuán-López, Esteban Cano-Jiménez, Olalla Castro-Añón, Luis A Pérez de Llano Respiratory Medicine Service, University Hospital ...
Golpe R, Pérez de Llano LA, Martín-Robles I, Cano-Jiménez E, Castro-Añón O, Sanjuán-López P, Suárez-Valor M   +6 more
core  

Germline predisposition and somatic mutational landscape in synchronous mucinous metaplasia and neoplasia of the female genital tract

Clinical and Translational Medicine
Background Synchronous mucinous metaplasia and neoplasia of the female genital tract (SMMN‐FGT) with gastric‐type differentiation is a rare disorder with genetic predisposition.
Ying Yuan, Li Zhang, Jiongbo Liao, Bo Wang, Linghui Lu, Dongchen Chu, Yue Shi, Jiaqi Liu, Feng Zhang, Shuyan Tang, Chao Wang   +10 more
doaj   +1 more source

A comprehensive reference catalog of human skin DNA virome reveals novel viral diversity and microenvironmental influences

Microbiology Spectrum
Human skin serves as a dynamic habitat for a diverse microbiome, including a complex array of viruses whose diversity and roles are not fully understood. A total of 2,760 skin metagenomes from 6 published skin studies were collected.
Zhiming Li, Shenghui Li, Chongyin Han, Yuxiao Chen, Hefu Zhen, Yuzhe Sun, Xiaofeng Zhou, Yanmei Chen, Yan Zheng, Lianyi Han, Jean Krutmann, Chao Nie, Jiucun Wang, Jingjing Xia   +13 more
doaj   +1 more source

Sarcoidosis Phenotypes

Open Respiratory Archives, 2021
Joel Francesqui, Fernanda Hernández-González, Jacobo Sellarés   +2 more
openaire   +3 more sources

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source