Results 61 to 70 of about 340,700 (262)

Megavirus baoshanense Mb0671 modulates host translation and increases viral fitness

Frontiers in Microbiology
Amoeba giant viruses encode many translation-related proteins, but the function of these proteins remains obscure. In the current work, we studied the potential eukaryotic translation initiation factor 4A (eIF4A, Mb0671) encoded by Megavirus baoshanense,
Wenya Bian, Jie Yang, Yucheng Xia, Yun Li, Yanjin Cheng, Yuchen Wu, Jianhua Gan, Jiang Zhong   +7 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Integrated multi-omics analysis reveals GPD1L-mediated dysregulation of glycerophospholipid metabolism facilitates the progression of lung adenocarcinoma

Respiratory Research
Background With the widespread of low-dose computed tomography (LDCT), an increasing number of early-stage lung adenocarcinomas (LUAD) presenting as ground-glass opacity (GGO) nodules are being detected.
Yifu Sun, Yueren Yan, Yudi Zhou, Yuting Chen, Chunnan Liu, Yufang Bao, Yang Zhang, Han Han, Haiquan Chen   +8 more
doaj   +1 more source

ClpC1-dependent iron homeostasis underlies mycobacterial defense against oxygen-driven Fenton reaction during reactivation

Microbiology Spectrum
The caseinolytic protease (Clp) system, which is highly conserved and essential for protein homeostasis in mycobacteria, comprises the ClpP1P2 proteolytic core and the essential ATPases ClpC1 and ClpX.
Mingzhe Chi, Yuqing Zheng, Wenkai Zheng, Youran Chen, Bohong Zhou, Jiayu Chen, Jiacheng Bai, Yuchang Di, Xuelian Zhang   +8 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

A correlation between human ABO phenotypes and periodontal status [PDF]

, 2015
Objectives: To investigate the frequency of periodontal diseases among ABO blood groups and the Rh factors. Materials and Methods: the double-blind cross-sectional study was conducted on 200 systemically healthy subjects (90) males and (110) females ...
Faraedon M. Zardawi, Harem J. Hama Rashed   +1 more
core   +2 more sources

AARS2-catalyzed lactylation induces follicle development and premature ovarian insufficiency

Cell Death Discovery
Lactate, a metabolite which is elevated in various developmental and pathological processes, exerts its signal through alanyl tRNA synthetases (AARS)-catalyzed protein lactylation.
Zhi-Ling Zhang, Shu-Ting Ren, Wan-Jie Yang, Xiao-Wen Xu, Shi-Min Zhao, Ke-Fei Fang, Yan Lin, Yi-Yuan Yuan, Xiao-Jin Zhang, Yun-Qin Chen, Wei Xu   +10 more
doaj   +1 more source

The Universal Phenotype

, 2019
Organisms. Journal of Biological Sciences, V. 3, N. 2 (2019)
Alessio Martino, Alessandro Giuliani, Antonello Rizzi   +2 more
openaire   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Phenotypes

, 2012
This file contains the non-genetic data on each individual in the study. "Adipose" refers to the presence or absence of the adipose fin; salmon hatcheries in this region generally remove this fin prior to release.
Quinn, Thomas P., Paul L. Faulds (3249954), Faulds, Paul L., William I. Atlas (511624), Thomas P. Quinn (272754), Anderson, Joseph H., Atlas, William I., Joseph H. Anderson (3249957)   +7 more
core   +1 more source