Results 51 to 60 of about 340,700 (262)

Multiple phenotypes in genome-wide genetic mapping studies

, 2011
For many psychiatric and other traits, diagnoses are based on a number of different criteria or phenotypes. Rather than carrying out genetic analyses on the final diagnosis, it has been suggested that relevant phenotypes should be analyzed directly.
Ott, Jurg, Ott, J (reprint author), Chinese Acad Sci, Key Lab Mental Hlth, Inst Psychol, Beijing 100101, Peoples R China., Wang, Jing   +2 more
core   +1 more source

Variability in disease phenotypes within a single PRNP genotype suggests the existence of multiple natural sheep scarpie strains within Europe [PDF]

, 2010
Variability of pathological phenotypes within classical sheep scrapie cases has been reported for some time, but in many instances it has been attributed to differences in the PRNP genotype of the host.
González, L., E. Monleon, L. J. M. van Keulen, Jeffrey, M., Balkema-Buschmann, A., C. Hoffmann, Badiola, J.J., Lulini, B., Keulen, L.J.M., van, van Keulen, L.J.M., A. Balkema-Buschmann, Monleón, E., S. Siso, A. Ortiz-Pelaez, Langeveld, J.P.M., Hoffmann, C., J. J. Badiola, Sisó, S., Acín, C., Ortiz-Peláez, A., J. P. M. Langeveld, B. Iulini, M. Jeffrey, L. Gonzalez, C. Casalone, Casalone, C., C. Acin   +26 more
core   +1 more source

Sucrose-activated TOR and phyA signaling alleviates shade-mediated inhibition of leaf development in Arabidopsis

Nature Communications
To over-top the neighbors, shade-intolerant plants trigger shade avoidance responses with increasing the elongation of stem-like organs at the expense of leaf development. Shade-induced elongation growth has been extensively studied, while the regulatory
Jiayu Wang, Fengquan Li, Caiyi Lu, Lin Li   +3 more
doaj   +1 more source

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Benchmarking Q40 sequencing for sensitive and efficient detection of rare genomic variants

Genome Biology
Background Phred quality score (Q score) is critical for sequencing accuracy, yet the impact of Q40-achieving sequencing technologies (99.99% accuracy) on detecting subtle biological variations remains unvalidated.
Shumeng Duan, Yaqing Liu, Xiaorou Guo, Zhiyin An, Ruiwen Ma, Qiaochu Chen, Yanming Xie, Qingwang Chen, Ying Yu, Lianhua Dong, Leming Shi, Yuanting Zheng   +11 more
doaj   +1 more source

Characterization of Methicillin-Resistant Staphylococcus aureus Isolates from Periprosthetic Joint Infections

Pathogens, 2022
Periprosthetic joint infection (PJI) is a troublesome clinical issue in total joint arthroplasty (TJA). Although methicillin-resistant Staphylococcus aureus (MRSA) is considered to be the most serious pathogen in PJIs, little is known about the genotypic
Jiun-Liang Chen, Tsung-Yu Huang, Wei-Bin Hsu, Chiang-Wen Lee, Yao-Chang Chiang, Pey-Jium Chang, Kuo-Ti Peng   +6 more
doaj   +1 more source

Phenotyping bleeding [PDF]

Current Opinion in Hematology, 2012
Although recorded evidence of phenotyping bleeding disorders extends back two millennia, standardization of phenotyping has only begun in the past half century. This was spurred by the need for greater precision in diagnosing disorders in order to select proper laboratory tests and treatment, and the realization that the bleeding history provides ...
Paula, James, Barry S, Coller
openaire   +2 more sources

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Phenotypes of childhood asthma: are they real? [PDF]

, 2010
It has been suggested that there are several distinct phenotypes of childhood asthma or childhood wheezing. Here, we review the research relating to these phenotypes, with a focus on the methods used to define and validate them.
Silverman, M., B. D. Spycher, C. E. Kuehni, Spycher, Ben, Kühni, Claudia, M. Silverman   +5 more
core   +1 more source

Intergeneric chromosomal transfer in yeast results in improved phenotypes and widespread transcriptional responses

Nature Communications
Interspecific genetic exchanges caused by natural hybridization or horizontal gene transfer can lead to enhanced phenotypes, which are often of interest for industrial applications and evolutionary research.
Yilin Lyu, Yi Shi, Kunfeng Song, Jungang Zhou, Hao Chen, Xueying C. Li, Yao Yu, Hong Lu   +7 more
doaj   +1 more source