Results 71 to 80 of about 340,700 (262)

Proximal correlates of metabolic phenotypes during 'at-risk' and 'case' stages of the metabolic disease continuum [PDF]

, 2012
Extent: 11p.OBJECTIVE: To examine the social and behavioural correlates of metabolic phenotypes during ‘at-risk’ and ‘case’ stages of the metabolic disease continuum. DESIGN: Cross-sectional study of a random population sample.
Grant, J. F., Grant, J.F., Haren, M., McDermott, R., Howe, P. R. C., Buckley, J., Haren, M.T., Haren, M. T., McDermott, Robyn, Buckley, J. D., Newbury, J., Misan, G., Taylor, A. W., McDermott, R. A., Buckley, J.D., Howe, P., Grant, J., Taylor, A.W., Howe, P.R.C., Taylor, A.   +19 more
core   +1 more source

PhenoDP: leveraging deep learning for phenotype-based case reporting, disease ranking, and symptom recommendation

Genome Medicine
Background Current phenotype-based diagnostic tools often struggle with accurate disease prioritization due to incomplete phenotypic data and the complexity of rare disease presentations.
Baole Wen, Sheng Shi, Yi Long, Yanan Dang, Weidong Tian   +4 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Analysis of multiple phenotypes in genome-wide genetic mapping studies

, 2013
Background: Complex traits may be defined by a range of different criteria. It would result in a loss of information to perform analyses simply on the basis of a final clinical dichotomized affected / unaffected variable.
Murray, Robin, Bramon, Elvira, Picchioni, Marco, Ott, Jurg, Toulopoulou, Timothea, Walshe, Muriel, Suo, Chen, Suo, C (reprint author), Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Beijing 100101, Peoples R China.   +7 more
core   +1 more source

Single-nucleus multi-omics analysis of mouse small-intestinal Lgr5+ cell populations reveals Foxa3-induced Paneth cell-lineage differentiation

Communications Biology
Lgr5+ stem cells play crucial roles in maintaining intestinal epithelial cell homeostasis. However, the cellular heterogeneity and underlying regulatory programs of Lgr5+ small intestinal stem cells (ISCs) remain elusive.
Xinran Deng, Shenfei Sun, Chenqi Lu, Hanxiao Du, Xiaoyu You, Fujing Huang, Kai Gong, Jingxin Guo, Yumou Gong, Runrong Li, Xingyu Yu, Bing Zhao, Xinhua Lin, Ning Jiang   +13 more
doaj   +1 more source

Transcriptomic analysis of reduced thermotolerance in Arabidopsis seedlings lacking the metacaspase AtMC1

Frontiers in Plant Science
More frequent short-term episodes of extreme high temperatures caused by global warming seriously threaten plant growth and development around the world.
Lin Chen, Xiaochun Ge
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Use of isoenzyme and protein phenotypes to discriminate between six Pratylenchus species from Great Britain

, 1995
Six species of Pratylenchus indigenous to Great Britain, P. crenatus, P. fallax, P. neglectus, P. penetrans, P. pinguicaudatus and P. thornei were analysed by slab gel electrophoresis to compare protein patterns and isoenzyme phenotypes of esterase ...
Ibrahim, S. K., Perry, R. N., Webb, R. M.   +2 more
core   +1 more source

Activation of ERBB4 Pathway Inhibits Pathological Transdifferentiation of Lung Epithelial Progenitors into CD66c+ Basal Cells in Severe Lung Injury

Advanced Science
Aberrant accumulation of basal cells in the distal lung is a hallmark of impaired epithelial regeneration and is closely associated with fibrotic remodeling; however, their cellular origins and the mechanisms governing their expansion remain unclear ...
Kaijun Lin, Xinran Deng, Haonan Wang, Yamei Jiang, Jian Sun, Hailin Ding, Ming Ye, Xiaoting Wang, Yu Wang, Li Yuan, Zhenju Song, Xinhua Lin, Shenfei Sun, Ning Jiang   +13 more
doaj   +1 more source

Enhanced Risk Prediction for Coronary Heart Disease by Leveraging Polygenic Risk Score and Clinical Risk Score in European Hypertensive Adults

Journal of Cardiovascular Development and Disease
Background: Coronary heart disease (CHD) is the leading cause of premature mortality. The incremental value of a polygenic risk score (PRS) to a clinical risk score towards improving CHD prediction is controversial.
Siyuan Shen, Yuquan Wang, Yue-Qing Hu
doaj   +1 more source