Results 41 to 50 of about 340,700 (262)

Protein-level batch-effect correction enhances robustness in MS-based proteomics

Nature Communications
Batch effects, defined as unwanted technical variations caused by differences in labs, pipelines, or batches, are notorious in MS-based proteomics data, wherein protein quantities are inferred from precursor- and peptide-level intensities.
Qiaochu Chen, Zehui Cao, Yaqing Liu, Naixin Zhang, Yanming Xie, Haonan Chen, Yuanbang Mai, Shumeng Duan, Jiaqi Li, Ying Yu, Yang Zhao, Leming Shi, Yuanting Zheng   +12 more
doaj   +1 more source

Asthma Phenotypes

Seminars in Respiratory and Critical Care Medicine, 2012
The identification of phenotypes of asthma has a long history, but previous classifications have not identified clinically important differences in pathology, natural history, or treatment response. Progress has accelerated recently, fueled by the development of new techniques to assess airway disease, particularly noninvasive techniques to assess ...
openaire   +3 more sources

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Phenotypes of cough in children: A latent class analysis. [PDF]

, 2023
INTRODUCTION Distinguishing phenotypes among children with cough helps understand underlying causes. Using a statistical data-driven approach, we aimed to identify and validate cough phenotypes based on measurable traits, physician diagnoses, and ...
Blanchon, Sylvain, Latzin, Philipp, Moeller, A., Mallet, Maria Christina, Blanchon, S., Moeller, Alexander, Goutaki, Myrofora, Hoyler, K., Spycher, B.D., Regamey, Nicolas, Goutaki, M., Kuehni, C.E., Hoyler, Karin, Spycher, Ben D, Pedersen, ESL, Jochmann, A., Makhoul, Ronny, Kuehni, Claudia E, Mallet, M.C., Makhoul, R., Jochmann, Anja, Latzin, P., Pedersen, Eva S L, Regamey, N.   +23 more
core   +3 more sources

phenotypes

, 2014
In this file you find all traits measured for each individual (Resistance, Tolerance, Size...)
Géraldine Loot (3244239), David James Páez (3244242), Elise Mazé-Guilmo (3244236), Páez, David James, Lefèvre, Thierry, Mazé-Guilmo, Elise, Loot, Géraldine, Blanchet, Simon, Simon Blanchet (92497), Thierry Lefèvre (63585)   +9 more
core   +2 more sources

Mitochondrial retrograde signaling initiates HIF-1α/BNIP3/NIX-mediated mitophagy in Tibetan high-altitude adaptation

Cell Death Discovery
Genome-wide studies have identified the nuclear gene EPAS1 and the mitochondrial M9a haplogroup as pivotal contributors to hypoxia adaptation in Tibetans. However, the interaction between these two genetic components is not yet clear.
Yang Wei, Dayan Sun, Fei Wu, Shixuan Zhang, Bowen Cai, Yanyun Ma, Hongxiang Zheng, Xiangguang Shi, Yi Li, Shiguan Le, Xiang Zhou, Li Jin, Jiucun Wang   +12 more
doaj   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Initial Modelling of the Alternative Phenotypes Hypothesis

, 2008
The alternative phenotype hypothesis contends that multiple phenotypes exist in a single genotype and are expressed by environmental or genetic cues. It further states that these multiple phenotypes will be maintained and improved in a population where ...
Worgan, Simon, Mills, Rob
core   +1 more source

A phosphorylation switch in the Mediator MED15 controls cellular senescence and cognitive decline

Cell Discovery
A hallmark of aging is chronic systemic inflammation, which is exacerbated by the hypersecretory aging phenotype known as the senescence-associated secretory phenotype (SASP).
Haozheng Li, Yuanming Zheng, Chunlei Yuan, Jiayi Wang, Xiaying Zhao, Ming Yang, Defei Xiong, Yenan Yang, Yunpeng Dai, Yiming Gao, Yuqi Wang, Lei Xue, Gang Wang   +12 more
doaj   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source