Results 231 to 240 of about 156,060 (249)

p16Ink4a‐Positive Hepatocytes Drive Liver Fibrosis Through Activation of LIFR Family Pathway

Advanced Science, EarlyView.
This study found that, following the long‐term CCl4 treatment, p16high hepatocytes appeared in zone 3, spatially co‐localizing with fibrotic areas. A specific cluster of p16high hepatocytes upregulated CTF1/LIF expression which induced HSC activation and further liver fibrosis, as revealed by single cell transcriptomic analysis.
Koji Nishikawa, Teh‐Wei Wang, Satoshi Kawakami, Shota Tanimoto, Kiyoshi Yamaguchi, Taketomo Kido, Masamichi Kimura, Tsunekazu Hishima, Yuki T. Okamura, Satotaka Omori, Takumi Iritani, Toshikaze Chiba, Takehiro Jimbo, Michio Katano, Kansuporn Kamataki, Ryoichi Yokoyama, Eigo Shimizu, Kiminori Kimura, Satoshi Yamzaki, Seiya Imoto, Yoichi Furukawa, Atsushi Miyajima, Yoshikazu Johmura, Makoto Nakanishi   +23 more
wiley   +1 more source

High resolution mapping of agro-morphological and grain traits in bread wheat using SNP-based QTL analysis. [PDF]

PLoS One
Jadon V, Gajghate R, Devate NB, Amaresh, Krishna H, Krishnappa G, Dosad S, Jain N, Singh PK, Singh GP.   +9 more
europepmc   +1 more source

Targeting Itga8 Mitigates Neurogenic Bladder Fibrosis Driven by Trem2⁺ Macrophage‐Derived Fn1 via FAK/RhoA/ROCK Signaling

Advanced Science, EarlyView.
Normal bladders exhibit quiescent fibroblasts/macrophages, whereas neurogenic bladders show acute‐phase Itga8⁺ fibroblast expansion driven by Trem2⁺ macrophage‐secreted Fn1, which activates FAK/RhoA/ROCK signaling, promotes cytoskeletal remodeling, and upregulates pro‐fibrotic genes.
Jiaxin Wang, Siyuan Wang, Lida Ren, Xinqi Liu, Lei Zhang, Peng Hu, Wenchao Xu, Shuaixiang Zheng, Jihong Liu, Qing Ling   +9 more
wiley   +1 more source

Genome-Wide Association Study Reveals Novel QTNs and Candidate Genes Implicated in Resistance to Northern Corn Leaf Blight in Maize (<i>Zea mays</i> L.). [PDF]

Int J Mol Sci
Shetty U, Sowmya MS, Lohithaswa HC, Mallikarjuna MG, Jadesha G, Nayaka SC.   +5 more
europepmc   +1 more source

Astrocytic PERK Deficiency Drives Prefrontal Circuit Dysfunction and Depressive‐Like Behaviors

Advanced Science, EarlyView.
Chen et al. show that the endoplasmic reticulum (ER) stress sensor PERK is downregulated in prefrontal cortex (PFC) astrocytes in major depressive disorder and in chronic‐stress mouse models. In young mice, astrocyte‐specific PERK loss reduces the synaptogenic cue thrombospondin‐1 (TSP1), leading to synaptic and circuit deficits and depressive‐like ...
Kai Chen, Riya Gupta, Yosuke M. Morizawa, Yu Qin, Xingyu Du, Cynthia Pang, Osama Al‐Dalahmah, Maura B. Dupont, Guang Yang   +8 more
wiley   +1 more source

QTL/Segment Mapping and Candidate Gene Analysis for Oil Content Using a Wild Soybean Chromosome Segment Substitution Line Population. [PDF]

Plants (Basel)
Liu C, Ren J, Wen H, Zhen C, Han W, Chen X, He J, Liu F, Sun L, Xing G, Zhao J, Gai J, Wang W.   +12 more
europepmc   +1 more source

Potent and Long‐Lasting Immunogenicity Generated by LNP‐mRNA gE Antigen Against Varicella Zoster Virus via an AI‐Assisted Pipeline

Advanced Science, EarlyView.
This study designs a novel mRNA‐LNP vaccine targeting VZV glycoprotein E (gE) for herpes zoster via an AI‐assisted pipeline. Validated in mice and rhesus macaques, the mRNA‐LNP vaccine shows strong humoral and cellular immune responses, with CD4+ T‐cell responses more effective and durable than Shingrix, offering a promising prophylactic option ...
Kai Dong, Fang Liu, Dawei Wang, Yanfen Li, Man Zhang, Yuting Zhou, Gengshen Song   +6 more
wiley   +1 more source

CDK4/6 Inhibition Induces CD8+ T Cell Antitumor Immunity via MIF‐Induced Functional Orchestration of Tumor‐Associated Macrophages

Advanced Science, EarlyView.
CDK4/6 inhibition promotes CD8+ T cell expansion through tumor‐macrophage crosstalk by activating HIF‐1α and enhancing MIF‐CD44/CD74 signaling. This reprograms TAMs to boost MHC‐I antigen presentation, and CDK4/6 inhibitor‐trained M1 TAM supernatant therapy synergizes with low‐dose PD‐1 blockade to restore antitumor immunity.
Lin He, Yuzhong Peng, Lat‐lun Leong, Jingbo Zhou, Dongyang Tang, Weilu Wang, Xiaoran Wu, Josh haipeng Lei, Yongqin Ye, Yangyang Feng, Yunfeng Qiao, Xiangpeng Chu, Di Mu, Qi Zhao, Tzuming Liu, Yan Chen, Paul Kwonghang Tam, Chu‐Xia Deng   +17 more
wiley   +1 more source

Changes in phenology mediate vertebrate population responses to temperature globally. [PDF]

Nat Commun
Radchuk V, Jones CV, McLean N, Charmantier A, Teplitsky C, Alisauskas R, Ancona S, Anker-Nilssen T, Arcese P, Arlt D, Aubry LM, Bailey L, Barbraud C, Berg KS, Berteaux D, Blumstein DT, Bouwhuis S, Brose U, Brouwer L, Catry P, Chero G, Chiaradia A, Courtiol A, Daunt F, Delord K, Dobson FS, Drummond H, Eeva T, Fauteux D, Gauthier G, Genovart M, Granadeiro JP, Hentati-Sundberg J, Harris M, Igual JM, Janzen F, Keogan K, Korpimäki E, Kramer-Schadt S, Kruuk LEB, Lewis S, Mallory M, Martin J, Massot M, Matthysen E, Mihoub JB, Møller AP, Nater CR, Newell M, Oppel S, Oro D, Ortega S, Parejo D, Pärt T, Payo-Payo A, Pemberton J, Phillips RA, Pillay N, Avilés JM, Rödel HG, Sanz-Aguilar A, Saraux C, Schielzeth H, Schradin C, Schroeder J, Sheldon BC, Tavecchia G, Tarwater CE, Veiberg V, Viblanc VA, von Holst D, Vriend SJG, Wanless S, Wheelwright N, Wood AG, Sæther BE, Jenouvrier S, Clobert J, Beissinger SR, Visser ME, Reed TE, van de Pol M.   +81 more
europepmc   +1 more source

Genomics Insights Into High‐Latitude Adaptation of Tibetan Macaques

Advanced Science, EarlyView.
Tibetan macaques exhibit unique adaptations to cold, high‐latitude environments, including shortened tails and enhanced fat storage. Genomic analyses reveal a species‐specific TBX6 mutation linked to tail reduction and selection on lipid metabolism genes.
Rusong Zhang, Ying Hu, Yang Teng, Jiwei Qi, Yangzhen Ciren, Lin Zhang, Qiao Du, Wencai Xu, Liang Zhou, Zhenxin Fan, Jinchuan Xing, Ming Li, Jing Li   +12 more
wiley   +1 more source