Results 91 to 100 of about 216,179 (302)

Fine scale diversity in the lava: genetic and phenotypic diversity in small populations of Arctic charr Salvelinus alpinus [PDF]

Background A major goal in evolutionary biology is to understand the processes underlying phenotypic variation in nature. Commonly, studies have focused on large interconnected populations or populations found along strong environmental gradients ...
Ferguson, Moira, Skúlason, Skúli, Katja Räsänen, Morrissey, Michael, Moira Ferguson, Leblanc, Camille A., Räsänen, Katja, Kristjánsson, Bjarni K., Michael Morrissey, Skúli Skúlason, Bjarni K. Kristjánsson, Camille A. Leblanc   +11 more
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Gene duplication: a drive for phenotypic diversity and cause of human disease

, 2007
Gene duplication is one of the key factors driving genetic innovation, i.e., producing novel genetic variants. Although the contribution of whole-genome and segmental duplications to phenotypic diversity across species is widely appreciated, the ...
Conrad, Bernard, Antonarakis, Stylianos E, Antonarakis, Stylianos   +2 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Phenotypic diversity of enset (Ensete ventricosum (Welw.) Cheesman) landraces used in traditional medicine [PDF]

, 2019
Enset (Ensete ventricosum (Welw.) Cheesman) is a multipurpose food security crop extensively cultivated in southern and southwestern parts of Ethiopia. In addition to its wide consumption as a source of food and feed, some enset landraces are also used ...
Tesfaye, Kassahun, Tadele, Zerihun, Demissew, Sebsebe, Nuraga, Gizachew Woldesenbet, Feyissa, Tileye   +4 more
core   +1 more source

The Path Towards Novel Varieties: Investigating Phenotypic-Genetic Diversity in New Promising Egyptian Rice Lines

Agronomy
Rice (Oryza sativa L.) has an impressive range of phenotypic and genetic diversity, making it an important crop for global food security. Since rice phenotypic and genetic diversity are essential for enhancing the sustainability of rice production, an ...
Waleed A. Almasoud, Mahmoud Abdel-Sattar, Saber Sedeek, Amgad A. Elgammaal, Nouran El-Refaee, Ibrahem A. Ramadan, Dina Abdulmajid, Hail Z. Rihan   +7 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

Variation of fruit phenotypic traits of Cinnamomum camphora from 11 provenances in China.

PLoS ONE
This study aimed to characterize the diversity and variation of fruit phenotypic traits in natural provenances of Cinnamomum camphora to facilitate the selection of superior germplasm.
Shengying Wan, Jiao Zhao, Jie Ma, Jie Zhang, Qingqing Liu, Changlong Xiao, Jiexi Hou, Zhinong Jin   +7 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source